دورية أكاديمية
Effects of induction chemotherapy on nutrition status in locally advanced nasopharyngeal carcinoma: a multicentre prospective study.
| العنوان: | Effects of induction chemotherapy on nutrition status in locally advanced nasopharyngeal carcinoma: a multicentre prospective study. |
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| المؤلفون: | Miao J; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Wang L; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Ong EHW; Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Hu C; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China., Lin S; Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China., Chen X; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China., Chen Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Zhong Y; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China., Jin F; Department of Head and Neck Oncology, The Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guiyang, China., Lin Q; Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, China., Lin S; Department of Radiation Oncology, Hainan Cancer Hospital, Haikou, China., Hu X; Department of Radiation Oncology, The First People's Hospital of Foshan, Foshan, Guangdong, China., Zhang N; Department of Radiation Oncology, The First People's Hospital of Foshan, Foshan, Guangdong, China., Wang R; Department of Radiation Oncology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China., Wang C; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Guo X; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Yit NLF; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore., Shi H; Department of Gastrointestinal Surgery and Clinical Nutrition, Beijing Shijitan Hospital, Beijing, China., Tan SH; Division of Clinical Trials & Epidemiological Sciences, National Cancer Center Singapore, Singapore.; Oncology Academic Programme, Duke-NUS Medical School, Singapore., Mai H; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China., Xie C; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China., Chua MLK; Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Oncology Academic Programme, Duke-NUS Medical School, Singapore.; Department of Head and Neck and Thoracic Cancers, Division of Radiation Oncology, National Cancer Centre Singapore, Singapore., Zhao C; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China. |
| المصدر: | Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2023 Apr; Vol. 14 (2), pp. 815-825. Date of Electronic Publication: 2023 Mar 05. |
| نوع المنشور: | Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Berlin : John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Original Publication: Heidelburg : Springer-Verlag |
| مواضيع طبية MeSH: | Nutritional Status* , Nasopharyngeal Neoplasms*/drug therapy , Nasopharyngeal Neoplasms*/pathology, Humans ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/radiotherapy ; Prospective Studies ; Quality of Life ; Cisplatin/adverse effects ; Induction Chemotherapy ; Fluorouracil/therapeutic use |
| مستخلص: | Background: Induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT) is the standard of care for locoregionally advanced nasopharyngeal carcinoma (LA-NPC). This intensive treatment regimen increases acute toxicities, which could negatively impact patients' nutritional status. We conducted this prospective, multicentre trial to investigate the effects of IC and CCRT on nutritional status in LA-NPC patients, so as to provide evidence for further study of nutritional intervention, which was registered in ClinicalTrials.gov (NCT02575547). Methods: Patients with biopsy-proven NPC and planned for IC + CCRT were recruited. IC entailed two cycles of 3-weekly docetaxel 75 mg/m 2 and cisplatin 75 mg/m 2 ; CCRT entailed two to three cycles of 3-weekly cisplatin 100 mg/m 2 depending on the duration of radiotherapy. Nutritional status and quality of life (QoL) were assessed pre-IC, post-cycles one and two of IC, W4 and W7 of CCRT. Primary endpoint was the cumulative proportion of ≥ 5.0% weight loss (WL Results: One hundred and seventy-one patients were enrolled. Median follow-up was 67.4 (IQR: 64.1-71.2) months. 97.7% (167/171) patients completed two cycles of IC, and 87.7% (150/171) completed at least two cycles of concurrent chemotherapy; all, except one patient (0.6%), completed IMRT. WL was minimal during IC (median of 0.0%), but increased sharply at W4-CCRT (median of 4.0% [IQR: 0.0-7.0%]) and peaked at W7-CCRT (median of 8.5% [IQR: 4.1-11.7%]). 71.9% (123/171) of patients recorded a WL Conclusions: We observed a high prevalence of WL among LA-NPC patients who were treated with IC + CCRT, which peaked during CCRT, and had a detriment on patients' QoL. Our data support the need to monitor patient's nutritional status during the later phase of treatment with IC + CCRT and inform on nutritional intervention strategies. (© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.) |
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| معلومات مُعتمدة: | 82073330 National Natural Science Foundation of China; 81872469 National Natural Science Foundation of China; 320.6750.17108 Wu Jieping Medical Foundation; 320.6750.19089 Wu Jieping Medical Foundation; CSAINV20nov-0021 National Medical Research Council Singapore Clinician Scientist Award; NMRC/CSA-INV/0027/2018 National Medical Research Council Singapore Clinician Scientist Award; Duke-NUS Oncology Academic Program Goh Foundation Proton Research Programme; NCCS Cancer Fund; Kua Hong Pak Head and Neck Cancer Research Programme; Z-2017-24-2108 Immune-radiotherapy Research Foundation of Chinese Medical Association Radiation Oncology |
| فهرسة مساهمة: | Keywords: Concurrent chemoradiotherapy; Induction chemotherapy; Locoregionally advanced nasopharyngeal carcinoma; Nutritional status; Quality of life; Survival |
| سلسلة جزيئية: | ClinicalTrials.gov NCT02575547 |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) 65595-90-6 (W 7) U3P01618RT (Fluorouracil) |
| تواريخ الأحداث: | Date Created: 20230305 Date Completed: 20230404 Latest Revision: 20230406 |
| رمز التحديث: | 20230406 |
| مُعرف محوري في PubMed: | PMC10067484 |
| DOI: | 10.1002/jcsm.13196 |
| PMID: | 36872457 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2190-6009 |
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| DOI: | 10.1002/jcsm.13196 |