دورية أكاديمية
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Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells.

التفاصيل البيبلوغرافية
العنوان: Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells.
المؤلفون: Huang C; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China., Deng W; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China., Xu HZ; Department of Pediatrics, Division of Infectious Diseases, College of Medicine, University of Florida, Gainesville, FL, USA., Zhou C; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China., Zhang F; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China., Chen J; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China., Bao Q; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China., Zhou X; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China., Liu M; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China., Li J; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China.; University of Chinese Academy of Sciences, Beijing, China., Liu C; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China.
المصدر: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Feb 13; Vol. 21, pp. 1606-1620. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology Country of Publication: Netherlands NLM ID: 101585369 Publication Model: eCollection Cited Medium: Print ISSN: 2001-0370 (Print) Linking ISSN: 20010370 NLM ISO Abbreviation: Comput Struct Biotechnol J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology
Original Publication: Gothenburg, Sweden : Research Network of Computational and Structural Biotechnology
مستخلص: Short-chain fatty acids (SCFAs) exhibit anticancer activity in cellular and animal models of colon cancer. Acetate, propionate, and butyrate are the three major SCFAs produced from dietary fiber by gut microbiota fermentation and have beneficial effects on human health. Most previous studies on the antitumor mechanisms of SCFAs have focused on specific metabolites or genes involved in antitumor pathways, such as reactive oxygen species (ROS) biosynthesis. In this study, we performed a systematic and unbiased analysis of the effects of acetate, propionate, and butyrate on ROS levels and metabolic and transcriptomic signatures at physiological concentrations in human colorectal adenocarcinoma cells. We observed significantly elevated levels of ROS in the treated cells. Furthermore, significantly regulated signatures were involved in overlapping pathways at metabolic and transcriptomic levels, including ROS response and metabolism, fatty acid transport and metabolism, glucose response and metabolism, mitochondrial transport and respiratory chain complex, one-carbon metabolism, amino acid transport and metabolism, and glutaminolysis, which are directly or indirectly linked to ROS production. Additionally, metabolic and transcriptomic regulation occurred in a SCFAs types-dependent manner, with an increasing degree from acetate to propionate and then to butyrate. This study provides a comprehensive analysis of how SCFAs induce ROS production and modulate metabolic and transcriptomic levels in colon cancer cells, which is vital for understanding the mechanisms of the effects of SCFAs on antitumor activity in colon cancer.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.)
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فهرسة مساهمة: Keywords: 1H–13C HMBC, 1H–13C Heteronuclear Multiple Bond Correlation Spectroscopy; 1H–13C HSQC, 1H–13C Heteronuclear Single Quantum Coherence Spectroscopy; 1H–1H COSY, 1H–1H Correlation Spectroscopy; 1H–1H TOCSY, 1H–1H Total Correlation Spectroscopy; ADP, Adenosine diphosphate; AMP, Adenosine monophosphate; ATP, Adenosine triphosphate; Ace, Acetate; Ach, Acetylcholine; Ala, Alanine; CRC, Colorectal Cancer; Caco-2, Human Colon Adenocarcinoma; Cho, Choline; CoA, Coenzyme A; Cre, Creatine; DCFH-DA, Dichloro-Dihydro-Fluorescein Diacetate; DEGs, Differentially Expressed Genes; DMEM, Dulbecco's Modified Eagle Medium; DMG, Dimethylglycine; DNA, Deoxyribonucleic Acid; EP, Eppendorf; FA, Formate; FDR, False Discovery Rate; Fru, Fructose; Fum, Fumaric acid; GLS, Glutaminase; GSEA, Gene Set Enrichment Analysis; GSH, Glutathione; Gal-1-P, Galactose-1-phosphate; Glc, Glucose; Gln, Glutamine; Glu, Glutamate; Gly, Glycine; HCT116, Human Colorectal Carcinoma Cell Line; HEK, Human Embryonic Kidney cells; HT29, Human Colorectal Adenocarcinoma Cell Line with Epithelial Morphology; His, Histidine; Ile, Isoleucine; J-Res, J-resolved Spectroscopy; LDH, Lactate Dehydrogenase; Lac, Lactate; Leu, Leucine; Lys, Lysine; MCF-7, Human Breast Cancer Cell Line with Estrogen; MCT, Monocarboxylate Transporters; Met, Methionine; MetS, Metabolic Syndrome; Mitochondrial function; NAD+, Nicotinamide adenine dinucleotide; NAG, N-Acetyl-L-Glutamine; NMR, Nuclear Magnetic Resonance; NMR-based Metabolomics; NOESY, Nuclear Overhauser Effect Spectroscopy; O-PLS-DA, Orthogonal Projection to the Latent Structures Discriminant Analysis; PA, Pantothenate; PC, Phosphocholine; PCA, Principal Component Analysis; PDC, Pyruvate Decarboxylase; PDK, Pyruvate Dehydrogenase Kinase; PKC, Protein Kinase C; PPP, Pentose Phosphate Pathway; Phe, Phenylalanine; Pyr, Pyruvate; RNA, Ribonucleic Acid; ROS, Reactive Oxygen Species; RPKM, Reads per Kilobase of Transcript per Million Reads Mapped; Reactive oxygen species; SCFAs, Short Chain Fatty Acids; SLC, Solute-Carrier Genes; Short-chain fatty acids; Suc, Succinate; T2DM, Type 2 Diabetes; TCA, Tricarboxylic Acid; Tau, Taurine; Thr, Threonine; Transcriptomics; Tyr, Tyrosine; UDP, Uridine 5′-diphosphate; UDP-GLC, UDP Glucose; UDPG, UDP Glucuronate; UDPGs, UDP Glucose and UDP Glucuronate; UMP, Uridine 5′-monophosphate; Val, Valine; WST-1, Water-Soluble Tetrazolium salts; dDNP, dissolution Dynamic Nuclear Polarization; qRT-PCR, Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction; α-KIV, α-Keto-isovalerate; α-KMV, α-keto-β-methyl-valerate
تواريخ الأحداث: Date Created: 20230306 Latest Revision: 20230307
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9975252
DOI: 10.1016/j.csbj.2023.02.022
PMID: 36874158
قاعدة البيانات: MEDLINE
الوصف
تدمد:2001-0370
DOI:10.1016/j.csbj.2023.02.022