A robust lyophilized kit for convenient one-step formulation of [ 68 Ga]Ga-DOTA-E-[c(RGDfK)] 2 in hospital radiopharmacy for clinical PET imaging.

التفاصيل البيبلوغرافية
العنوان:	A robust lyophilized kit for convenient one-step formulation of [ ⁶⁸ Ga]Ga-DOTA-E-[c(RGDfK)] 2 in hospital radiopharmacy for clinical PET imaging.
المؤلفون:	Das S; Radiopharmaceuticals Program, Board of Radiation and Isotope Technology, Navi Mumbai, India; Homi Bhabha National Institute, Mumbai, India., Sahu S; Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India., Chakraborty A; Homi Bhabha National Institute, Mumbai, India; Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India., Kamaleshwaran KK; Department of Nuclear Medicine and PET, Kovai Medical Centre and Hospital, Coimbatore, India., Bannore TU; Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India., Damle A; Homi Bhabha National Institute, Mumbai, India; Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India., Chakravarty R; Homi Bhabha National Institute, Mumbai, India; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India., Chakraborty S; Homi Bhabha National Institute, Mumbai, India; Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India. Electronic address: sudipta@barc.gov.in.
المصدر:	Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2023 Jun; Vol. 196, pp. 110725. Date of Electronic Publication: 2023 Feb 16.
نوع المنشور:	Case Reports; Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Pergamon Press Country of Publication: England NLM ID: 9306253 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9800 (Electronic) Linking ISSN: 09698043 NLM ISO Abbreviation: Appl Radiat Isot Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford ; New York : Pergamon Press, c1993-
مواضيع طبية MeSH:	Gallium Radioisotopes* , Positron-Emission Tomography*/methods, Male ; Mice ; Animals ; Humans ; Middle Aged ; Mice, SCID ; Heterocyclic Compounds, 1-Ring ; Cell Line, Tumor
مستخلص:	The present article describes the development of robust lyophilized kit for convenient formulation of [ ⁶⁸ Ga]Ga-DOTA-E-[c(RGDfK)] 2 (E = glutamic acid, R = arginine, G = glycine, D = aspartic acid, f = phenylalanine, K = lysine) radiopharmaceutical for clinical use in non-invasive monitoring of malignancies overexpressing integrin α v β 3 receptors. Five batches of the kit were prepared with optimized kit contents, all of which showed high ⁶⁸ Ga-radiolabeling yield (>98%). Pre-clinical evaluation of the [ ⁶⁸ Ga]Ga-radiotracer in SCID mice bearing FTC133 tumour exhibited significant accumulation in the tumor xenograft. Preliminary human clinical investigation carried out in a 60 year old male patient with metastatic lung cancer revealed high radiotracer uptake in the tumor along with satisfactory target to non-target contrast. The developed kit formulation also showed a long shelf-life of at least 12 months on storage at 0 °C. All these results point towards the promising attributes of the developed kit formulation for convenient preparation of [ ⁶⁸ Ga]Ga-DOTA-E-[c(RGDfK)] 2 for routine clinical use. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة:	Keywords: (68)Ga; Angiogenesis; DOTA-E−[c(RGDfK)](2); Integrin α(v)β(3); Lyophilized kit; PET imaging
المشرفين على المادة:	1HTE449DGZ (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) 0 (Gallium Radioisotopes) 0 (Heterocyclic Compounds, 1-Ring)
تواريخ الأحداث:	Date Created: 20230306 Date Completed: 20230417 Latest Revision: 20230417
رمز التحديث:	20231215
DOI:	10.1016/j.apradiso.2023.110725
PMID:	36878089
قاعدة البيانات:	MEDLINE

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تدمد:	1872-9800
DOI:	10.1016/j.apradiso.2023.110725