دورية أكاديمية
أعرض في EDS

Possible etiological association of ovine papillomaviruses with bladder tumors in cattle.

التفاصيل البيبلوغرافية
العنوان: Possible etiological association of ovine papillomaviruses with bladder tumors in cattle.
المؤلفون: De Falco F; Dipartimento di Medicina Veterinaria e delle Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy., Cuccaro B; Dipartimento di Medicina Veterinaria e delle Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy., De Tullio R; Dipartimento di Medicina Sperimentale (DIMES), Università degli Studi di Genova, Genova, Italy., Alberti A; Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Italy., Cutarelli A; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Naples, Italy., De Carlo E; Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Naples, Italy., Roperto S; Dipartimento di Medicina Veterinaria e delle Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy. Electronic address: sante.roperto@unina.it.
المصدر: Virus research [Virus Res] 2023 Apr 15; Vol. 328, pp. 199084. Date of Electronic Publication: 2023 Mar 06.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7492 (Electronic) Linking ISSN: 01681702 NLM ISO Abbreviation: Virus Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science, c1984-
مواضيع طبية MeSH: Bovine papillomavirus 1*/genetics , Urinary Bladder Neoplasms*/veterinary , Urinary Bladder Neoplasms*/etiology , Urinary Bladder Neoplasms*/metabolism , Cattle Diseases* , Papillomavirus Infections*/complications , Papillomavirus Infections*/veterinary, Animals ; Cattle ; Sheep ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Polymerase Chain Reaction ; Carcinogenesis
مستخلص: Introduction: Bladder tumors of cattle are very uncommon accounting from 0.1% to 0.01% of all bovine malignancies. Bladder tumors are common in cattle grazing on bracken fern-infested pasturelands. Bovine papillomaviruses have a crucial role in tumors of bovine urinary bladder.
Aim of the Study: To investigate the potential association of ovine papillomavirus (OaPV) infection with bladder carcinogenesis of cattle.
Methods: Droplet digital PCR was used to detect and quantify the nucleic acids of OaPVs in bladder tumors of cattle that were collected at public and private slaughterhouses.
Results: OaPV DNA and RNA were detected and quantified in 10 bladder tumors of cattle that were tested negative for bovine papillomaviruses. The most prevalent genotypes were OaPV1 and OaPV2. OaPV4 was rarely observed. Furthermore, we detected a significant overexpression and hyperphosphorylation of pRb and a significant overexpression and activation of the calpain-1 as well as a significant overexpression of E2F3 and of phosphorylated (activated) PDGFβR in neoplastic bladders in comparison with healthy bladders, which suggests that E2F3 and PDGFβR may play an important role in OaPV-mediated molecular pathways that lead to bladder carcinogenesis.
Conclusion: In all tumors, OaPV RNA could explain the causality of the disease of the urinary bladder. Therefore, persistent infections by OaPVs could be involved in bladder carcinogenesis. Our data showed that there is a possible etiologic association of OaPVs with bladder tumors of cattle.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Bladder tumors; Calpains; Cattle; Cross-species infection; Ovine papillomaviruses; PDGFβR
تواريخ الأحداث: Date Created: 20230306 Date Completed: 20230321 Latest Revision: 20230522
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10194246
DOI: 10.1016/j.virusres.2023.199084
PMID: 36878382
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7492
DOI:10.1016/j.virusres.2023.199084