دورية أكاديمية
Clinical utility of endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling of pancreatic cancer.
| العنوان: | Clinical utility of endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling of pancreatic cancer. |
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| المؤلفون: | Okuno N; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Hara K; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Mizuno N; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Haba S; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Kuwahara T; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Kuraishi Y; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Fumihara D; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan., Yanaidani T; Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan. |
| المصدر: | Clinical endoscopy [Clin Endosc] 2023 Mar; Vol. 56 (2), pp. 221-228. Date of Electronic Publication: 2023 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society of Gastrointestinal Endoscopy Country of Publication: Korea (South) NLM ID: 101576886 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2234-2400 (Print) Linking ISSN: 22342400 NLM ISO Abbreviation: Clin Endosc Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Society of Gastrointestinal Endoscopy |
| مستخلص: | Background/aims: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is essential for the diagnosis of pancreatic cancer. The feasibility of comprehensive genomic profiling (CGP) using samples obtained by EUS-TA has been under recent discussion. This study aimed to evaluate the utility of EUS-TA for CGP in a clinical setting. Methods: CGP was attempted in 178 samples obtained from 151 consecutive patients with pancreatic cancer at the Aichi Cancer Center between October 2019 and September 2021. We evaluated the adequacy of the samples for CGP and determined the factors associated with the adequacy of the samples obtained by EUS-TA retrospectively. Results: The overall adequacy for CGP was 65.2% (116/178), which was significantly different among the four sampling methods (EUS-TA vs. surgical specimen vs. percutaneous biopsy vs. duodenal biopsy, 56.0% [61/109] vs. 80.4% [41/51] vs. 76.5% [13/17] vs. 100.0% [1/1], respectively; p=0.022). In a univariate analysis, needle gauge/type was associated with adequacy (22 G fine-needle aspiration vs. 22 G fine-needle biopsy [FNB] vs. 19 G-FNB, 33.3% (5/15) vs. 53.5% (23/43) vs. 72.5% (29/40); p=0.022). The sample adequacy of 19 G-FNB for CGP was 72.5% (29/40), and there was no significant difference between 19 G-FNB and surgical specimens (p=0.375). Conclusion: To obtain adequate samples for CGP with EUS-TA, 19 G-FNB was shown to be the best in clinical practice. However, 19 G-FNB was not still sufficient, so further efforts are required to improve adequacy for CGP. |
| التعليقات: | Comment in: Clin Endosc. 2023 Mar;56(2):183-184. (PMID: 36941791) |
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| فهرسة مساهمة: | Keywords: Endoscopic ultrasound-guided fine needle aspiration; Genome; Pancreatic neoplasms |
| تواريخ الأحداث: | Date Created: 20230307 Latest Revision: 20230407 |
| رمز التحديث: | 20230407 |
| مُعرف محوري في PubMed: | PMC10073855 |
| DOI: | 10.5946/ce.2022.086 |
| PMID: | 36879539 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2234-2400 |
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| DOI: | 10.5946/ce.2022.086 |