دورية أكاديمية
[Effect of continuous renal replacement therapy on plasma concentration, clinical efficacy and safety of colistin sulfate].
| العنوان: | [Effect of continuous renal replacement therapy on plasma concentration, clinical efficacy and safety of colistin sulfate]. |
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| المؤلفون: | Peng D; Department of Critical Care Medicine, People's Hospital of Henan University, Zhengzhou 450003, Henan, China., Zhang F; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Li Z; Department of Respiratory and Critical Care Medicine, Henan Chest Hospital, Zhengzhou 450003, Henan, China., Lyu P; Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Guo Z; Department of Critical Care Medicine, People's Hospital of Henan University, Zhengzhou 450003, Henan, China., Chen Y; Department of Critical Care Medicine, People's Hospital of Henan University, Zhengzhou 450003, Henan, China., Zhao J; Department of Clinical Research Center, Henan Province People's Hospital, Zhengzhou 450003, Henan, China., Niu J; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Guo B; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Jia W; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Jiang X; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Li X; Department of Cardiac Surgecal Intensive Care Unit, Henan Chest Hospital, Zhengzhou 450003, Henan, China., Qi S; Department of Critical Care Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China. Corresponding author: Shao Huanzhang, Email: shaohuanzhang@sina.com., Qin B; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China., Shao H; Department of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China. |
| المصدر: | Zhonghua wei zhong bing ji jiu yi xue [Zhonghua Wei Zhong Bing Ji Jiu Yi Xue] 2023 Jan; Vol. 35 (1), pp. 88-92. |
| نوع المنشور: | Multicenter Study; English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: |
| أسماء مطبوعة: | Original Publication: Beijing Shi : "Zhonghua yi xue za zhi" she, 2013- |
| مواضيع طبية MeSH: | Continuous Renal Replacement Therapy*, Humans ; Colistin/therapeutic use ; Prospective Studies ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Objective: To investigate the effects of continuous renal replacement therapy (CRRT) on plasma concentration, clinical efficacy and safety of colistin sulfate. Methods: Clinical data of patients received with colistin sulfate were retrospectively analyzed from our group's previous clinical registration study, which was a prospective, multicenter observation study on the efficacy and pharmacokinetic characteristics of colistin sulfate in patients with severe infection in intensive care unit (ICU). According to whether patients received blood purification treatment, they were divided into CRRT group and non-CRRT group. Baseline data (gender, age, whether complicated with diabetes, chronic nervous system disease, etc), general data (infection of pathogens and sites, steady-state trough concentration, steady-state peak concentration, clinical efficacy, 28-day all-cause mortality, etc) and adverse event (renal injury, nervous system, skin pigmentation, etc) were collected from the two groups. Results: A total of 90 patients were enrolled, including 22 patients in the CRRT group and 68 patients in the non-CRRT group. (1) There was no significant difference in gender, age, basic diseases, liver function, infection of pathogens and sites, colistin sulfate dose between the two groups. Compared with the non-CRRT group, the acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) were higher in the CRRT group [APACHE II: 21.77±8.26 vs. 18.01±6.34, P < 0.05; SOFA: 8.5 (7.8, 11.0) vs. 6.0 (4.0, 9.0), P < 0.01], serum creatinine level was higher [μmol/L: 162.0 (119.5, 210.5) vs. 72.0 (52.0, 117.0), P < 0.01]. (2) Plasma concentration: there was no significant difference in steady-state trough concentration between CRRT group and non-CRRT group (mg/L: 0.58±0.30 vs. 0.64±0.25, P = 0.328), nor was there significant difference in steady-state peak concentration (mg/L: 1.02±0.37 vs. 1.18±0.45, P = 0.133). (3) Clinical efficacy: there was no significant difference in clinical response rate between CRRT group and non-CRRT group [68.2% (15/22) vs. 80.9% (55/68), P = 0.213]. (4) Safety: acute kidney injury occurred in 2 patients (2.9%) in the non-CRRT group. No obvious neurological symptoms and skin pigmentation were found in the two groups. Conclusions: CRRT had little effect on the elimination of colistin sulfate. Routine blood concentration monitoring (TDM) is warranted in patients received with CRRT. |
| المشرفين على المادة: | Z67X93HJG1 (Colistin) |
| تواريخ الأحداث: | Date Created: 20230307 Date Completed: 20230308 Latest Revision: 20230308 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3760/cma.j.cn121430-20220906-00819 |
| PMID: | 36880245 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2095-4352 |
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| DOI: | 10.3760/cma.j.cn121430-20220906-00819 |