دورية أكاديمية
أعرض في EDS

Local delivery of FK506 to a nerve allograft is comparable to systemic delivery at suppressing allogeneic graft rejection.

التفاصيل البيبلوغرافية
العنوان: Local delivery of FK506 to a nerve allograft is comparable to systemic delivery at suppressing allogeneic graft rejection.
المؤلفون: Davis B; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Wojtalewicz S; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Erickson S; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Veith J; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Simpson A; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Sant H; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah, United States of America., Shea J; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America., Gale B; Department of Mechanical Engineering, University of Utah, Salt Lake City, Utah, United States of America., Agarwal J; Department of Surgery, University of Utah, Salt Lake City, Utah, United States of America.
المصدر: PloS one [PLoS One] 2023 Mar 07; Vol. 18 (3), pp. e0281911. Date of Electronic Publication: 2023 Mar 07 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Axons* , Nerve Regeneration* , Tacrolimus*/pharmacology , Graft Rejection*/drug therapy , Graft Rejection*/prevention & control, Animals ; Mice ; Allografts ; Drug Delivery Systems
مستخلص: The objective of this study was to determine if locally delivered FK506 could prevent allogeneic nerve graft rejection long enough to allow axon regeneration to pass through the nerve graft. An 8mm mouse sciatic nerve gap injury repaired with a nerve allograft was used to assess the effectiveness of local FK506 immunosuppressive therapy. FK506-loaded poly(lactide-co-caprolactone) nerve conduits were used to provide sustained local FK506 delivery to nerve allografts. Continuous and temporary systemic FK506 therapy to nerve allografts, and autograft repair were used as control groups. Serial assessment of inflammatory cell and CD4+ cell infiltration into the nerve graft tissue was performed to characterize the immune response over time. Nerve regeneration and functional recovery was serially assessed by nerve histomorphometry, gastrocnemius muscle mass recovery, and the ladder rung skilled locomotion assay. At the end of the study, week 16, all the groups had similar levels of inflammatory cell infiltration. The local FK506 and continuous systemic FK506 groups had similar levels of CD4+ cell infiltration, however, it was significantly greater than the autograft control. In terms of nerve histmorphometry, the local FK506 and continunous systemic FK506 groups had similar amounts of myelinated axons, although they were significantly lower than the autograft and temporary systemic FK506 group. The autograft had significantly greater muscle mass recovery than all the other groups. In the ladder rung assay, the autograft, local FK506, and continuous systemic FK506 had similar levels of skilled locomotion performance, whereas the temporary systemic FK506 group had significanty better performance than all the other groups. The results of this study suggest that local delivery of FK506 can provide comparable immunosuppression and nerve regeneration outcomes as systemically delivered FK506.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Davis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
References: Neurol Med Chir (Tokyo). 2006 Feb;46(2):62-7; discussion 67-8. (PMID: 16498214)
Neurosurg Focus. 2009 Feb;26(2):E5. (PMID: 19435445)
J Oral Maxillofac Surg. 1992 Aug;50(8):803-5. (PMID: 1634971)
Exp Neurol. 2003 Sep;183(1):220-31. (PMID: 12957505)
Curr Opin Organ Transplant. 2018 Oct;23(5):568-576. (PMID: 30074507)
Transplantation. 2018 Oct;102(10):1684-1694. (PMID: 29794937)
Muscle Nerve. 2019 Nov;60(5):613-620. (PMID: 31397908)
Adv Drug Deliv Rev. 2016 Dec 15;107:163-175. (PMID: 27426411)
Muscle Nerve. 2000 Apr;23(4):633-40. (PMID: 10716776)
J Am Acad Orthop Surg. 2000 Jul-Aug;8(4):243-52. (PMID: 10951113)
Plast Reconstr Surg. 2001 May;107(6):1419-29. (PMID: 11335811)
Neural Regen Res. 2018 Jul;13(7):1247-1252. (PMID: 30028334)
Eur J Neurosci. 2010 Mar;31(6):1074-90. (PMID: 20377620)
Hand Clin. 2016 May;32(2):127-40. (PMID: 27094886)
J Burn Care Res. 2020 Nov 30;41(6):1172-1178. (PMID: 32352521)
Sci Transl Med. 2014 Aug 13;6(249):249ra110. (PMID: 25122638)
J Bone Joint Surg Am. 2012 Mar 7;94(5):410-7. (PMID: 22398734)
Cell. 2015 Aug 27;162(5):1127-39. (PMID: 26279190)
J Neurosurg. 2006 Oct;105(4):602-9. (PMID: 17044565)
Can J Plast Surg. 2003 Spring;11(1):15-22. (PMID: 24115844)
Plast Reconstr Surg. 1987 Mar;79(3):436-46. (PMID: 3823218)
Hand Clin. 2013 Aug;29(3):331-48. (PMID: 23895714)
Pain. 1998 May;76(1-2):215-22. (PMID: 9696476)
J Reconstr Microsurg. 2013 Mar;29(3):141-8. (PMID: 23322540)
Ann Plast Surg. 2005 Apr;54(4):420-7. (PMID: 15785285)
Prog Neurobiol. 1994 Jun;43(3):187-233. (PMID: 7816927)
Plast Reconstr Surg. 1993 Oct;92(5):916-26. (PMID: 8415974)
Eur J Neurosci. 2016 Feb;43(3):271-86. (PMID: 26228942)
Neuroscience. 1992;46(3):585-93. (PMID: 1545911)
Mol Immunol. 2020 May;121:81-91. (PMID: 32172028)
Transplantation. 1995 Feb 27;59(4):530-6. (PMID: 7533345)
Am J Transplant. 2011 Apr;11(4):693-7. (PMID: 21446974)
Int J Pharm. 2020 Oct 15;588:119703. (PMID: 32739385)
Adv Healthc Mater. 2016 Nov;5(21):2732-2744. (PMID: 27600578)
Front Cell Neurosci. 2016 Jun 14;10:151. (PMID: 27378849)
Biomed Res Int. 2014;2014:698256. (PMID: 25276813)
Acta Neuropathol. 2015 Nov;130(5):605-18. (PMID: 26419777)
J Neuroinflammation. 2011 Aug 30;8:110. (PMID: 21878126)
Muscle Nerve. 2011 Aug;44(2):221-34. (PMID: 21660979)
Ann Plast Surg. 1995 Oct;35(4):396-401. (PMID: 8585683)
Open Orthop J. 2014 Jun 27;8:199-203. (PMID: 25067975)
Nat Rev Immunol. 2015 Feb;15(2):117-29. (PMID: 25614321)
Prog Neurobiol. 2010 Nov;92(3):245-76. (PMID: 20950667)
Exp Neurol. 2019 Aug;318:216-231. (PMID: 31085199)
J Hand Ther. 1998 Apr-Jun;11(2):111-7. (PMID: 9602967)
PLoS One. 2016 Jun 10;11(6):e0156900. (PMID: 27285579)
Exp Neurol. 2021 Jul;341:113680. (PMID: 33675777)
J R Soc Interface. 2012 Feb 7;9(67):202-21. (PMID: 22090283)
Transpl Int. 2020 Apr;33(4):450-461. (PMID: 31930539)
Plast Reconstr Surg. 2017 Feb;139(2):403e-414e. (PMID: 28121868)
J Anat. 1988 Apr;157:127-34. (PMID: 3198473)
Histol Histopathol. 1995 Jul;10(3):709-18. (PMID: 7579822)
Injury. 2012 May;43(5):553-72. (PMID: 21269624)
J Neurosurg. 1993 Jan;78(1):90-100. (PMID: 8416248)
Neuroscience. 2004;129(3):767-77. (PMID: 15541898)
Restor Neurol Neurosci. 2000;17(1):39-44. (PMID: 11490076)
Muscle Nerve. 2004 Jun;29(6):812-22. (PMID: 15170614)
Restor Neurol Neurosci. 1994 Jan 1;6(4):287-96. (PMID: 21551759)
Plast Reconstr Surg. 1999 Jun;103(7):1928-36. (PMID: 10359255)
Clin Transplant. 1997 Jun;11(3):237-42. (PMID: 9193849)
Plast Reconstr Surg. 2005 Aug;116(2):484-94; discussion 495-6. (PMID: 16079678)
Int Rev Neurobiol. 2013;108:173-206. (PMID: 24083435)
معلومات مُعتمدة: R21 NS094983 United States NS NINDS NIH HHS
المشرفين على المادة: WM0HAQ4WNM (Tacrolimus)
تواريخ الأحداث: Date Created: 20230307 Date Completed: 20230309 Latest Revision: 20230418
رمز التحديث: 20230419
مُعرف محوري في PubMed: PMC9990949
DOI: 10.1371/journal.pone.0281911
PMID: 36881592
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0281911