دورية أكاديمية
Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology.
| العنوان: | Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology. |
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| المؤلفون: | Zhang J; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong., Chan CK; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong., Pavlović NM; Serbian Medical Society, Branch Niš, 18000 Niš, Serbia., Chan W; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong. |
| المصدر: | Chemical research in toxicology [Chem Res Toxicol] 2023 Mar 20; Vol. 36 (3), pp. 438-445. Date of Electronic Publication: 2023 Mar 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: Washington, DC : American Chemical Society, c1988- |
| مواضيع طبية MeSH: | Aristolochic Acids*/toxicity , Balkan Nephropathy*/chemically induced , Kidney Diseases*/chemically induced , Neoplasms*, Humans ; DNA Adducts/adverse effects ; Diet/adverse effects |
| مستخلص: | Prolonged exposure to aristolochic acids (AAs) through AA-containing herbal medicine or AA-contaminated food is associated with the development of aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), both public health risks to which the World Health Organization is calling for global action to remove exposure sources. The AA exposure-induced DNA damage is believed to be related to both the nephrotoxicity and carcinogenicity of AA observed in patients suffering from BEN. While the chemical toxicology of AA is well-studied, we investigated in this study the understated effect of different nutrients, food additives, or health supplements on DNA adduct formation by aristolochic acid I (AA-I). By culturing human embryonic kidney cells in an AAI-containing medium enriched with different nutrients, results showed that cells cultured in fatty acid-, acetic acid-, and amino acid-enriched media produced ALI-dA adducts at significantly higher frequencies than that cultured in the normal medium. ALI-dA adduct formation was most sensitive to amino acids, indicating that amino acid- or protein-rich diets might lead to a higher risk of mutation and even cancer. On the other hand, cells cultured in media supplemented with sodium bicarbonate, GSH, and NAC reduced ALI-dA adduct formation rates, which sheds light on their potential use as risk-mitigating strategies for people at risk of AA exposure. It is anticipated that the results of this study will help to better understand the effect of dietary habits on cancer and BEN development. |
| المشرفين على المادة: | 94218WFP5T (aristolochic acid I) 0 (Aristolochic Acids) 0 (DNA Adducts) |
| تواريخ الأحداث: | Date Created: 20230307 Date Completed: 20230321 Latest Revision: 20230323 |
| رمز التحديث: | 20230323 |
| DOI: | 10.1021/acs.chemrestox.2c00370 |
| PMID: | 36881864 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5010 |
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| DOI: | 10.1021/acs.chemrestox.2c00370 |