دورية أكاديمية
Automatic Segmentation of Parkinson Disease Therapeutic Targets Using Nonlinear Registration and Clinical MR Imaging: Comparison of Methodology, Presence of Disease, and Quality Control.
| العنوان: | Automatic Segmentation of Parkinson Disease Therapeutic Targets Using Nonlinear Registration and Clinical MR Imaging: Comparison of Methodology, Presence of Disease, and Quality Control. |
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| المؤلفون: | Miller CPK; Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Department of Neurosurgery, The University of Kansas School of Medicine, Kansas City, Kansas, USA., Muller J; Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Noecker AM; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA., Matias C; Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Alizadeh M; Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., McIntyre C; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA.; Department of Neurosurgery, School of Medicine, Duke University, Durham, North Carolina, USA., Wu C; Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. |
| المصدر: | Stereotactic and functional neurosurgery [Stereotact Funct Neurosurg] 2023; Vol. 101 (2), pp. 146-157. Date of Electronic Publication: 2023 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 8902881 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0372 (Electronic) Linking ISSN: 10116125 NLM ISO Abbreviation: Stereotact Funct Neurosurg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, [1989- |
| مواضيع طبية MeSH: | Parkinson Disease*/diagnostic imaging , Parkinson Disease*/therapy , Subthalamic Nucleus*/diagnostic imaging, Humans ; Brain ; Magnetic Resonance Imaging/methods ; Quality Control |
| مستخلص: | Introduction: Accurate and precise delineation of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) is critical for the clinical treatment and research of Parkinson's disease (PD). Automated segmentation is a developing technology which addresses limitations of visualizing deep nuclei on MR imaging and standardizing their definition in research applications. We sought to compare manual segmentation with three workflows for template-to-patient nonlinear registration providing atlas-based automatic segmentation of deep nuclei. Methods: Bilateral GPi, STN, and red nucleus (RN) were segmented for 20 PD and 20 healthy control (HC) subjects using 3T MRIs acquired for clinical purposes. The automated workflows used were an option available in clinical practice and two common research protocols. Quality control (QC) was performed on registered templates via visual inspection of readily discernible brain structures. Manual segmentation using T1, proton density, and T2 sequences was used as "ground truth" data for comparison. Dice similarity coefficient (DSC) was used to assess agreement between segmented nuclei. Further analysis was done to compare the influences of disease state and QC classifications on DSC. Results: Automated segmentation workflows (CIT-S, CRV-AB, and DIST-S) had the highest DSC for the RN and lowest for the STN. Manual segmentations outperformed automated segmentation for all workflows and nuclei; however, for 3/9 workflows (CIT-S STN, CRV-AB STN, and CRV-AB GPi) the differences were not statically significant. HC and PD only showed significant differences in 1/9 comparisons (DIST-S GPi). QC classification only demonstrated significantly higher DSC in 2/9 comparisons (CRV-AB RN and GPi). Conclusion: Manual segmentations generally performed better than automated segmentations. Disease state does not appear to have a significant effect on the quality of automated segmentations via nonlinear template-to-patient registration. Notably, visual inspection of template registration is a poor indicator of the accuracy of deep nuclei segmentation. As automatic segmentation methods continue to evolve, efficient and reliable QC methods will be necessary to support safe and effective integration into clinical workflows. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Atlas-based segmentation; Automated segmentation; Manual segmentation; Nonlinear registration; Parkinson disease; Template-to-patient |
| تواريخ الأحداث: | Date Created: 20230307 Date Completed: 20230405 Latest Revision: 20230410 |
| رمز التحديث: | 20230411 |
| DOI: | 10.1159/000526719 |
| PMID: | 36882011 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0372 |
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| DOI: | 10.1159/000526719 |