دورية أكاديمية
أعرض في EDS

Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes.

التفاصيل البيبلوغرافية
العنوان: Atrial secondary mitral regurgitation: prevalence, characteristics, management, and long-term outcomes.
المؤلفون: Straw S; University of Leeds, Leeds, UK.; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Gupta A; University of Leeds, Leeds, UK., Johnson K; Nelson Hospital, Nelson, New Zealand., Cole CA; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Kneizeh K; University Hospital Aachen, RWTH, Aachen, Germany., Gierula J; University of Leeds, Leeds, UK.; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Kearney MT; University of Leeds, Leeds, UK., Malkin CJ; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Paton MF; University of Leeds, Leeds, UK.; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Witte KK; University of Leeds, Leeds, UK. k.k.witte@leeds.ac.uk.; University Hospital Aachen, RWTH, Aachen, Germany. k.k.witte@leeds.ac.uk., Schlosshan D; Leeds Teaching Hospitals NHS Trust, Leeds, UK.
المصدر: Echo research and practice [Echo Res Pract] 2023 Mar 08; Vol. 10 (1), pp. 4. Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMC Country of Publication: England NLM ID: 101664713 Publication Model: Electronic Cited Medium: Print ISSN: 2055-0464 (Print) Linking ISSN: 20550464 NLM ISO Abbreviation: Echo Res Pract Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2022- : [London] : BMC
Original Publication: [Bristol] : Bioscientifica, [2014]-
مستخلص: Background: The prevalence, clinical characteristics, management and long-term outcomes of patients with atrial secondary mitral regurgitation (ASMR) are not well described.
Methods: We performed a retrospective, observational study of consecutive patients with grade III/IV MR determined by transthoracic echocardiography. The aetiology of MR was grouped as being either primary (due to degenerative mitral valve disease), ventricular SMR (VSMR: due to left ventricular dilatation/dysfunction), ASMR (due to LA dilatation), or other.
Results: A total of 388 individuals were identified who had grade III/IV MR; of whom 37 (9.5%) had ASMR, 113 (29.1%) had VSMR, 193 had primary MR (49.7%), and 45 (11.6%) were classified as having other causes. Compared to MR of other subtypes, patients with ASMR were on average older (median age 82 [74-87] years, p < 0.001), were more likely to be female (67.6%, p = 0.004) and usually had atrial fibrillation (83.8%, p = 0.001). All-cause mortality was highest in patients with ASMR (p < 0.001), but similar to that in patients with VSMR once adjusted for age and sex (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.52-1.25). Hospitalisation for worsening heart failure was more commonly observed in those with ASMR or VSMR (p < 0.001) although was similar between these groups when age and sex were accounted for (HR 0.74, 95% CI 0.34-1.58). For patients with ASMR, the only variables associated with outcomes were age and co-morbidities.
Conclusions: ASMR is a prevalent and distinct disease process associated with a poor prognosis, with much of this related to older age and co-morbidities.
(© 2023. The Author(s).)
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معلومات مُعتمدة: FS/CRTF/20/24071 United Kingdom BHF_ British Heart Foundation
فهرسة مساهمة: Keywords: Atrial fibrillation; Heart failure; Mitral regurgitation; Secondary mitral regurgitation; Valvular heart disease
تواريخ الأحداث: Date Created: 20230307 Latest Revision: 20230315
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9993529
DOI: 10.1186/s44156-023-00015-y
PMID: 36882790
قاعدة البيانات: MEDLINE
الوصف
تدمد:2055-0464
DOI:10.1186/s44156-023-00015-y