دورية أكاديمية
أعرض في EDS

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS.

التفاصيل البيبلوغرافية
العنوان: Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS.
المؤلفون: Ament Z; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Patki A; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Bhave VM; Harvard Medical School, Boston, MA, USA., Chaudhary NS; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Garcia Guarniz AL; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Kijpaisalratana N; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Division of Neurology, Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Judd SE; Department of Biostatistics, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA., Long DL; Department of Biostatistics, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Irvin MR; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Kimberly WT; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
المصدر: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2023 Jul; Vol. 43 (7), pp. 1089-1098. Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : Thousand Oaks, CA : SAGE Publications
Original Publication: New York : Raven Press, c1981-
مواضيع طبية MeSH: Gastrointestinal Microbiome* , Ischemic Stroke*/etiology , Stroke*/etiology, Humans ; Risk Factors ; Diet/adverse effects ; Biomarkers ; Incidence
مستخلص: Several metabolite markers are independently associated with incident ischemic stroke. However, prior studies have not accounted for intercorrelated metabolite networks. We used exploratory factor analysis (EFA) to determine if metabolite factors were associated with incident ischemic stroke. Metabolites (n = 162) were measured in a case-control cohort nested in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which included 1,075 ischemic stroke cases and 968 random cohort participants. Cox models were adjusted for age, gender, race, and age-race interaction (base model) and further adjusted for the Framingham stroke risk factors (fully adjusted model). EFA identified fifteen metabolite factors, each representing a well-defined metabolic pathway. Of these, factor 3, a gut microbiome metabolism factor, was associated with an increased risk of stroke in the base (hazard ratio per one-unit standard deviation, HR = 1.23; 95%CI = 1.15-1.31; P = 1.98 × 10 -10 ) and fully adjusted models (HR = 1.13; 95%CI = 1.06-1.21; P = 4.49 × 10 -4 ). The highest tertile had a 45% increased risk relative to the lowest (HR = 1.45; 95%CI = 1.25-1.70; P = 2.24 × 10 -6 ). Factor 3 was also associated with the Southern diet pattern, a dietary pattern previously linked to increased stroke risk in REGARDS (β = 0.11; 95%CI = 0.03-0.18; P = 8.75 × 10 -3 ). These findings highlight the role of diet and gut microbial metabolism in relation to incident ischemic stroke.
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معلومات مُعتمدة: P30 DK056336 United States DK NIDDK NIH HHS; R01 NS099209 United States NS NINDS NIH HHS; U01 NS041588 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Case-cohort; exploratory factor analysis; gut microbiome; ischemic stroke; metabolomics
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20230308 Date Completed: 20230626 Latest Revision: 20240309
رمز التحديث: 20240309
مُعرف محوري في PubMed: PMC10291458
DOI: 10.1177/0271678X231162648
PMID: 36883380
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-7016
DOI:10.1177/0271678X231162648