دورية أكاديمية
أعرض في EDS

Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.

التفاصيل البيبلوغرافية
العنوان: Alteration of neural activity and neuroinflammatory factors in the insular cortex of mice with corneal neuropathic pain.
المؤلفون: Xu R; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Zhang YW; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China., Gu Q; Department of Anesthesia, Children's Hospital of Fudan University, Shanghai, China., Yuan TJ; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Fan BQ; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Xia JM; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Wu JH; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Xia Y; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Li WX; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China., Han Y; Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.
المصدر: Genes, brain, and behavior [Genes Brain Behav] 2023 Apr; Vol. 22 (2), pp. e12842. Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: England NLM ID: 101129617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-183X (Electronic) Linking ISSN: 1601183X NLM ISO Abbreviation: Genes Brain Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Munksgaard, c2002-
مواضيع طبية MeSH: Neuralgia* , Dry Eye Syndromes*/chemically induced, Mice ; Animals ; Insular Cortex ; Neuroinflammatory Diseases ; Cerebral Cortex/diagnostic imaging
مستخلص: Dry eye disease (DED) affects nearly 55% of people worldwide; several studies have proposed that central sensitization and neuroinflammation may contribute to the developing corneal neuropathic pain of DED, while the underlying mechanisms of this contribution remain to be investigated. Excision of extra orbital lacrimal glands established the dry eye model. Corneal hypersensitivity was examined through chemical and mechanical stimulation, and open field test measured the anxiety levels. Restingstate fMRI is a method of functional magnetic resonance imaging (rs-fMRI) was performed for anatomical involvement of the brain regions. The amplitude of low-frequency fluctuation (ALFF) determined brain activity. Immunofluorescence testing and Quantitative real-time polymerase chain reaction were also performed to further validate the findings. Compared with the Sham group, ALFF signals in the supplemental somatosensory area, secondary auditory cortex, agranular insular cortex, temporal association areas, and ectorhinal cortex brain areas were increased in the dry eye group. This change of ALFF in the insular cortex was linked with the increment in corneal hypersensitivity (p < 0.01), c-Fos (p < 0.001), brain-derived neurotrophic factor (p < 0.01), TNF-α, IL-6, and IL-1β (p < 0.05). In contrast, IL-10 levels (p < 0.05) decreased in the dry eye group. DED-induced corneal hypersensitivity and upregulation of inflammatory cytokines could be blocked by insular cortex injection of Tyrosine Kinase receptor B agonist cyclotraxin-B (p < 0.01) without affecting anxiety levels. Our study reveals that the functional activity of the brain associated with corneal neuropathic pain and neuroinflammation in the insular cortex might contribute to dry eye-related corneal neuropathic pain.
(© 2023 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: central sensitization; corneal neuropathic pain; dry eye disease; insular cortex; the amplitude of low-frequency fluctuation
تواريخ الأحداث: Date Created: 20230308 Date Completed: 20230404 Latest Revision: 20230410
رمز التحديث: 20230410
مُعرف محوري في PubMed: PMC10067426
DOI: 10.1111/gbb.12842
PMID: 36889983
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-183X
DOI:10.1111/gbb.12842