دورية أكاديمية

A new iridoid from the roots of Valeriana jatamansi Jones with α-glucosidase activity.

التفاصيل البيبلوغرافية
العنوان: A new iridoid from the roots of Valeriana jatamansi Jones with α-glucosidase activity.
المؤلفون: Maurya AK; Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississippi, USA., Agnihotri VK; Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
المصدر: Natural product research [Nat Prod Res] 2024 Jul; Vol. 38 (14), pp. 2505-2510. Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
مواضيع طبية MeSH: Plant Roots*/chemistry , Valerian*/chemistry , Iridoids*/chemistry , Iridoids*/pharmacology , Iridoids*/isolation & purification , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification, Molecular Structure ; alpha-Glucosidases/metabolism ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Magnetic Resonance Spectroscopy
مستخلص: One new iridoid namely rupesin F ( 1 ) together with four known ones ( 2 - 5 ) were isolated from the roots of Valeriana jatamansi Jones. The structures were established using spectroscopic methods (1D and 2D NMR including HSQC, HMBC, COSY and NOESY) and by comparison with previously published literature data. The isolated compounds 1 and 3 exhibited strong α-glucosidase inhibition activity with IC 50 values of 10.13 ± 0.11 and 9.13 ± 0.03 μg/mL, respectively. This study enriched the chemical diversity of metabolites and provides a direction for the development of antidiabetic agents.
فهرسة مساهمة: Keywords: Valeriana jatamansi; iridoids; rupesin F; α-glucosidase
المشرفين على المادة: 0 (Iridoids)
0 (Glycoside Hydrolase Inhibitors)
EC 3.2.1.20 (alpha-Glucosidases)
0 (Hypoglycemic Agents)
تواريخ الأحداث: Date Created: 20230309 Date Completed: 20240710 Latest Revision: 20240710
رمز التحديث: 20240710
DOI: 10.1080/14786419.2023.2187796
PMID: 36890769
قاعدة البيانات: MEDLINE
الوصف
تدمد:1478-6427
DOI:10.1080/14786419.2023.2187796