دورية أكاديمية
أعرض في EDS

Bioactive compounds by microalgae and potentials for the management of some human disease conditions.

التفاصيل البيبلوغرافية
العنوان: Bioactive compounds by microalgae and potentials for the management of some human disease conditions.
المؤلفون: Eze CN; Department of Science Laboratory Technology, University of Nigeria Nsukka., Onyejiaka CK; Department of Microbiology, University of Nigeria Nsukka., Ihim SA; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical, University of Nigeria Nsukka., Ayoka TO; Department of Biochemistry, University of Nigeria Nsukka., Aduba CC; Department of Science Laboratory Technology, University of Nigeria Nsukka., Ndukwe JK; Department of Microbiology, University of Nigeria Nsukka.; UNESCO International Centre for Biotechnology, University of Nigeria Nsukka., Nwaiwu O; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom., Onyeaka H; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
المصدر: AIMS microbiology [AIMS Microbiol] 2023 Feb 07; Vol. 9 (1), pp. 55-74. Date of Electronic Publication: 2023 Feb 07 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: AIMS Press Country of Publication: United States NLM ID: 101697141 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-1888 (Electronic) Linking ISSN: 24711888 NLM ISO Abbreviation: AIMS Microbiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Springfield, MO : AIMS Press, [2015]-
مستخلص: Microalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-culture systems. Some of these bioactive compounds (such as polysaccharides, phycobiliproteins and lipids) are produced during their active growth phase. They appear to have antibacterial, antifungal, antiviral, antioxidative, anticancer, neuroprotective and chemo-preventive activities. These properties confer on microalgae the potential for use in the treatment and/or management of several neurologic and cell dysfunction-related disease conditions, including Alzheimer's disease (AD), AIDS and COVID-19, as shown in this review. Although several health benefits have been highlighted, there appears to be a consensus in the literature that the field of microalgae is still fledgling, and more research needs to be carried out to ascertain the mechanisms of action that underpin the effectiveness of microalgal compounds. In this review, two biosynthetic pathways were modeled to help elucidate the mode of action of the bioactive compounds from microalgae and their products. These are carotenoid and phycobilin proteins biosynthetic pathways. The education of the public on the importance of microalgae backed with empirical scientific evidence will go a long way to ensure that the benefits from research investigations are quickly rolled out. The potential application of these microalgae to some human disease conditions was highlighted.
Competing Interests: Conflict of interest: The authors declare no conflict of interest.
(© 2023 the Author(s), licensee AIMS Press.)
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فهرسة مساهمة: Keywords: Alzheimer's disease; active compounds; carotenoids; oxidative stress
تواريخ الأحداث: Date Created: 20230309 Latest Revision: 20230310
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9988413
DOI: 10.3934/microbiol.2023004
PMID: 36891530
قاعدة البيانات: MEDLINE
الوصف
تدمد:2471-1888
DOI:10.3934/microbiol.2023004