دورية أكاديمية
أعرض في EDS

Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae).

التفاصيل البيبلوغرافية
العنوان: Investigation of Antimicrobial, Anti-Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae).
المؤلفون: Başpınar Y; Pharmacognosy Graduate Program, Institute of Health Sciences, Erciyes University, Kayseri, Türkiye., Gürbüz P; Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri, 38039, Türkiye., Dilem Doğan Ş; Department of Basic Sciences, Faculty of Pharmacy, Erciyes University, Kayseri, Türkiye., Gözde Gündüz M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye., Aleksic I; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia., Vojnovic S; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia., Nikodinovic-Runic J; Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia., Yavuz Paksoy M; Program in Medical Documentation and Secretaryship, Tunceli Vocational School, Department of Medical Services and Techniques, Munzur University, Tunceli, Türkiye.
المصدر: Chemistry & biodiversity [Chem Biodivers] 2023 Apr; Vol. 20 (4), pp. e202300134. Date of Electronic Publication: 2023 Mar 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
مواضيع طبية MeSH: Anti-Infective Agents*/chemistry , Anti-Infective Agents*/pharmacology , Asteraceae*/chemistry , Flavonoids*/chemistry , Flavonoids*/pharmacology , Pulicaria*/chemistry , Quorum Sensing*/drug effects, Humans ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Molecular Docking Simulation ; Phytochemicals/chemistry ; Phytochemicals/metabolism ; Phytochemicals/pharmacology
مستخلص: This is the first report on the separation and biological assessment of all metabolites derived from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the eastern part of Turkey. The phytochemical analysis of P. armena resulted in the identification of one simple phenolic glucoside together with eight flavon and flavonol derivatives whose chemical structures were elucidated by NMR experiments and by the comparison of the spectral data with the relevant literature. The screening of all molecules for their antimicrobial, anti-quorum sensing, and cytotoxic activities revealed the biological potential of some of the isolated compounds. Additionally, quorum sensing inhibitory activity of quercetagetin 5,7,3' trimethyl ether was supported by molecular docking studies in the active site of LasR which is the primary regulator of this cell-to-cell communication system in bacteria. Lastly, the critical molecular properties indicating drug-likeness of the compounds isolated from P. armena were predicted. As microbial infections can be a serious problem for cancer patients with compromised immune systems, this comprehensive phytochemical research on P. armena with its anti-quorum sensing and cytotoxic compounds can provide a new approach to the treatment.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
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معلومات مُعتمدة: TYL-2020-10492 Research Foundation of Erciyes University
فهرسة مساهمة: Keywords: Antibacterial; Pulicaria sp; antifungal; cancer; molecular modeling
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
0 (Flavonoids)
0 (Phytochemicals)
تواريخ الأحداث: Date Created: 20230310 Date Completed: 20230505 Latest Revision: 20230505
رمز التحديث: 20230506
DOI: 10.1002/cbdv.202300134
PMID: 36898082
قاعدة البيانات: MEDLINE
الوصف
تدمد:1612-1880
DOI:10.1002/cbdv.202300134