دورية أكاديمية
أعرض في EDS

Experimental Autoimmune Encephalomyelitis of Mice: IgGs from the Sera of Mice Hydrolyze miRNAs.

التفاصيل البيبلوغرافية
العنوان: Experimental Autoimmune Encephalomyelitis of Mice: IgGs from the Sera of Mice Hydrolyze miRNAs.
المؤلفون: Nevinsky GA; Institute of Chemical Biology, Fundamental Medicine of the Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, Novosibirsk 630090, Russia., Urusov AE; Institute of Chemical Biology, Fundamental Medicine of the Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, Novosibirsk 630090, Russia., Aulova KS; Institute of Chemical Biology, Fundamental Medicine of the Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, Novosibirsk 630090, Russia., Ermakov EA; Institute of Chemical Biology, Fundamental Medicine of the Siberian Division of Russian Academy of Sciences, Lavrentiev Ave. 8, Novosibirsk 630090, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 23; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Encephalomyelitis, Autoimmune, Experimental* , MicroRNAs* , Antibodies, Catalytic*, Mice ; Animals ; Histones/metabolism ; Mice, Inbred C57BL ; Myelin-Oligodendrocyte Glycoprotein ; DNA
مستخلص: It was shown that the spontaneous development of experimental encephalomyelitis (EAE) in C57BL/6 mice occurs due to changes in the profile of bone marrow stem cells differentiation. This leads to the appearance of lymphocytes producing antibodies-abzymes that hydrolyze DNA, myelin basic protein (MBP), and histones. The activity of abzymes in the hydrolysis of these auto-antigens slowly but constantly increases during the spontaneous development of EAE. Treatment of mice with myelin oligodendrocyte glycoprotein (MOG) leads to a sharp increase in the activity of these abzymes with their maximum at 20 days (acute phase) after immunization. In this work, we analyzed changes in the activity of IgG-abzymes hydrolyzing (pA) 23 , (pC) 23 , (pU) 23 , and six miRNAs (miR-9-5p, miR-219a-5p, miR-326, miR-155-5p, miR-21-3p, and miR-146a-3p) before and after mice immunization with MOG. Unlike abzymes hydrolyzing DNA, MBP, and histones, the spontaneous development of EAE leads not to an increase but to a permanent decrease of IgGs activity of hydrolysis of RNA-substrates. Treatment of mice with MOG resulted in a sharp but transient increase in the activity of antibodies by day 7 (onset of the disease), followed by a sharp decrease in activity 20-40 days after immunization. A significant difference in the production of abzymes against DNA, MBP, and histones before and after mice immunization with MOG with those against RNAs may be since the expression of many miRNAs decreased with age. This can lead to a decrease in the production of antibodies and abzymes that hydrolyze miRNAs with age mice.
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معلومات مُعتمدة: 22-15-00103 the Russian Science Foundation
فهرسة مساهمة: Keywords: C57BL/6 mice; EAE model of human multiple sclerosis; catalytic antibodies; hydrolysis of RNAs and micro-RNAs; immunization with MOG
المشرفين على المادة: 0 (Histones)
0 (Myelin-Oligodendrocyte Glycoprotein)
0 (MicroRNAs)
0 (Antibodies, Catalytic)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20230311 Date Completed: 20230314 Latest Revision: 20230314
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10002156
DOI: 10.3390/ijms24054433
PMID: 36901861
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24054433