دورية أكاديمية
CCR5∆32 and SDF1 3'A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a Mixed Population of the Amazon Region of Brazil.
العنوان: | CCR5∆32 and SDF1 3'A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a Mixed Population of the Amazon Region of Brazil. |
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المؤلفون: | Lima ÉRG; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Queiroz MAF; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Lima SS; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Machado LFA; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Cayres-Vallinoto IMV; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Vallinoto ACR; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Figueiredo FAPL; Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Guerreiro JF; Human and Medical Genetics Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Guimarães Ishak MO; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil., Ishak R; Virus Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Mar 04; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 04. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Acquired Immunodeficiency Syndrome*/genetics , Chemokine CXCL12*/genetics , HIV Infections* , Receptors, CCR5*/genetics, Female ; Humans ; Male ; Biomarkers ; Brazil ; Disease Progression ; Gene Frequency ; HIV-1 ; Viremia |
مستخلص: | CCR5Δ32 and SDF1-3'A polymorphisms were investigated in a cohort of viremia controllers, without the use of therapy, along with their influence on CD4+ T lymphocytes (TLs), CD8+ TLs, and plasma viral load (VL). The samples were analyzed from 32 HIV-1-infected individuals classified as viremia controllers 1 and 2 and viremia non-controllers, from both sexes, mostly heterosexuals, paired with 300 individuals from a control group. CCR5∆32 polymorphism was identified by PCR amplification of a fragment of 189 bp for the wild-type allele and 157 bp for the allele with the ∆32 deletion. SDF1-3'A polymorphism was identified by PCR, followed by enzymatic digestion (restriction fragment length polymorphism) with the Msp I enzyme. The relative quantification of gene expression was performed by real-time PCR. The distribution of allele and genotype frequencies did not show significant differences between the groups. The gene expression of CCR5 and SDF1 was not different between the profiles of AIDS progression. There was no significant correlation between the progression markers (CD4+ TL/CD8+ TL and VL) and the CCR5∆32 polymorphism carrier status. The 3'A allele variant was associated with a marked loss of CD4+ TLs and a higher plasma VL. Neither CCR5∆32 nor SDF1-3'A was associated with viremia control or the controlling phenotype. |
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معلومات مُعتمدة: | #301869/2017-0; #312979/2018-5; #314209/2021-2 National Council for Scientific and Technological Development; FAPESPA/PRONEX-060/2020 Fundação Amazônia Paraense de Amparo a Estudos e Pesquisas; PAPQ/2019 Federal University of Para |
فهرسة مساهمة: | Keywords: CCR5; HIV-1; SDF1; gene variants; viremia controller |
المشرفين على المادة: | 0 (Biomarkers) 0 (Chemokine CXCL12) 0 (Receptors, CCR5) 0 (CXCL12 protein, human) 0 (CCR5 protein, human) |
تواريخ الأحداث: | Date Created: 20230311 Date Completed: 20230315 Latest Revision: 20230315 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC10003039 |
DOI: | 10.3390/ijms24054958 |
PMID: | 36902388 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms24054958 |