دورية أكاديمية
Atypical histone targets of PHD fingers.
| العنوان: | Atypical histone targets of PHD fingers. |
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| المؤلفون: | Black JC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA., Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104601. Date of Electronic Publication: 2023 Mar 11. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Histones*/chemistry , Histones*/metabolism , PHD Zinc Fingers*, DNA-Binding Proteins/metabolism ; Protein Binding ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Animals ; Mice ; Neoplasms/genetics ; Neoplasms/physiopathology |
| مستخلص: | Plant homeodomain (PHD) fingers are structurally conserved zinc fingers that selectively bind unmodified or methylated at lysine 4 histone H3 tails. This binding stabilizes transcription factors and chromatin-modifying proteins at specific genomic sites, which is required for vital cellular processes, including gene expression and DNA repair. Several PHD fingers have recently been shown to recognize other regions of H3 or histone H4. In this review, we detail molecular mechanisms and structural features of the noncanonical histone recognition, discuss biological implications of the atypical interactions, highlight therapeutic potential of PHD fingers, and compare inhibition strategies. Competing Interests: Conflict of interest The author declares that they have no conflicts of interest with the contents of this article. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | R01 GM125195 United States GM NIGMS NIH HHS; R01 CA252707 United States CA NCI NIH HHS; R01 GM135671 United States GM NIGMS NIH HHS; R01 HL151334 United States HL NHLBI NIH HHS; R01 AG067664 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: PHD; binding; chromatin; histone; inhibitor |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Histones) 0 (Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20230312 Date Completed: 20230515 Latest Revision: 20230515 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10124903 |
| DOI: | 10.1016/j.jbc.2023.104601 |
| PMID: | 36907441 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1083-351X |
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| DOI: | 10.1016/j.jbc.2023.104601 |