دورية أكاديمية
أعرض في EDS

Kidney transplantation from elderly donors (> 70 years): a systematic review.

التفاصيل البيبلوغرافية
العنوان: Kidney transplantation from elderly donors (> 70 years): a systematic review.
المؤلفون: Mesnard B; Department of Urology, Nantes Université, CHU Nantes, Nantes, France., Territo A; Uro-Oncology and Kidney Transplant Unit, Department of Urology at 'Fundació Puigvert' Hospital, Autonoma University of Barcelona, Barcelona, Spain., Campi R; Department of Urology, Florence University Hospital, Florence, Italy., Hevia V; Department of Urology, University Hospital Ramón y Cajal, Madrid, Spain., Andras I; Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Piana A; Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy., Pecoraro A; Department of Urology, Florence University Hospital, Florence, Italy., Boissier R; Department of Urology, La Conception University Hospital, Marseille, France., Prudhomme T; Department of Urology and Kidney Transplantation, Toulouse University Hospital, TSA 50032 Rangueil Hospital, 31059, Toulouse Cedex 9, France. prudhomme.t@chu-toulouse.fr.
مؤلفون مشاركون: EAU-Young Academic Urologist (YAU) group of Kidney Transplantation
المصدر: World journal of urology [World J Urol] 2023 Mar; Vol. 41 (3), pp. 695-707. Date of Electronic Publication: 2023 Mar 13.
نوع المنشور: Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Berlin ; New York] : Springer International, 1983-
مواضيع طبية MeSH: Kidney Transplantation*, Humans ; Female ; Aged ; Aged, 80 and over ; Delayed Graft Function ; Tissue Donors ; Kidney ; Graft Survival ; Age Factors
مستخلص: Purpose: The incidence of kidney transplants from elderly donors over 70 years of age has increased significantly over the past 10 years to reach 20% of available kidney graft in some European countries. However, there is little data available on the outcomes of transplants from these donors. We performed a systematic review to evaluate the outcomes of transplantation from donors over 70 years of age.
Methods: A systematic review was performed according to preferred reporting items for systematic reviews and meta-analyses. Medline, Embase, and Cochrane databases were searched to identify all studies reporting outcomes on kidney transplants from donors over 70 years. Due to the heterogeneity of the studies, a meta-analysis could not be performed.
Results: A total of 29,765 patients in 27 studies were included. The mean donors age was 74.79 years, and proportion of kidney graft from women was 53.54%. The estimated 1- and 5-year kidney death-censored graft survivals from donors > 70 years old were, respectively, 85.95 and 80.27%, and the patient survivals were 90.88 and 71.29%. The occurrence of delayed graft function was 41.75%, and primary non-function was 4.67%. Estimated graft function at 1 and 5 years was 36 and 38 mL/min/1.73 m 2 . Paucity data were available on post-operative complications.
Conclusions: Elderly donors appear to be a reliable source of grafts. However, these transplants are associated with a high rate of delayed graft function without repercussion on long-term graft survival. Allocation strategy to elderly recipients is the main factor of decreased recipient survival.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Investigator: A Pecoraro; T Prudhomme; R Boissier; V Hevia; R Campi; A Territo
Keywords: Aged, 70 and over; Donor selection; Graft survival; Kidney transplantation
تواريخ الأحداث: Date Created: 20230313 Date Completed: 20230411 Latest Revision: 20230411
رمز التحديث: 20231215
DOI: 10.1007/s00345-023-04311-4
PMID: 36907943
قاعدة البيانات: MEDLINE
الوصف
تدمد:1433-8726
DOI:10.1007/s00345-023-04311-4