CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques.
| العنوان: | CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques. |
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| المؤلفون: | Harwood OE; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711., Matschke LM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711., Moriarty RV; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711., Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711., Weaver AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711., Ellis-Connell AL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711., Weiler AM; Wisconsin National Primate Research Center, Madison, WI, 53711., Winchester LC; College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198., Fletcher CV; College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198., Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711.; Wisconsin National Primate Research Center, Madison, WI, 53711., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701., O'Connor DH; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711.; Wisconsin National Primate Research Center, Madison, WI, 53711., Lang JD; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711.; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI 53711., Reynolds MR; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711.; Wisconsin National Primate Research Center, Madison, WI, 53711., O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711.; Wisconsin National Primate Research Center, Madison, WI, 53711. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 02. Date of Electronic Publication: 2023 Mar 02. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-haplomatched cohort of MHC-M3+ SIVmac239+ Mauritian cynomolgus macaques (MCMs) initiated on ART at two weeks post-infection (wpi). For six months after ART withdrawal, we observed undetectable or transient viremia in seven of eight MCMs. In vivo depletion of CD8α+ cells induced rebound in all animals, indicating the PTC was mediated, at least in part, by CD8α+ cells. We found that MCMs had smaller acute viral reservoirs than a cohort of identically infected rhesus macaques, a population that rarely develops PTC. The mechanisms by which unusually small viral reservoirs and CD8α+ cell-mediated virus suppression enable PTC can be investigated using this MHC-haplomatched MCM model. Further, defining the immunologic mechanisms that engender PTC in this model may identify therapeutic targets for inducing durable HIV remission in humans. |
| التعليقات: | Update in: PLoS Pathog. 2023 Sep 25;19(9):e1011676. doi: 10.1371/journal.ppat.1011676. (PMID: 37747933) |
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| معلومات مُعتمدة: | P51 RR000167 United States RR NCRR NIH HHS; 75N91019D00024 United States CA NCI NIH HHS; 75N99020D00005 United States OF ORFDO NIH HHS; HHSN261201500003I United States CA NCI NIH HHS; 75N95020D00005 United States DA NIDA NIH HHS; P51 OD011106 United States OD NIH HHS; 75N93023D00005 United States AI NIAID NIH HHS; R01 AI108415 United States AI NIAID NIH HHS; 75N92020D00005 United States HL NHLBI NIH HHS; 75N93022D00005 United States AI NIAID NIH HHS; HHSN261201500003C United States CA NCI NIH HHS; P40 OD028116 United States OD NIH HHS; R01 AI124965 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20230313 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| مُعرف محوري في PubMed: | PMC10002716 |
| DOI: | 10.1101/2023.03.01.530655 |
| PMID: | 36909458 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.03.01.530655 |
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