دورية أكاديمية
أعرض في EDS

Lipid droplets as multifunctional organelles related to the mechanism of evasion during mycobacterial infection.

التفاصيل البيبلوغرافية
العنوان: Lipid droplets as multifunctional organelles related to the mechanism of evasion during mycobacterial infection.
المؤلفون: de Almeida PE; Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil., Pereira de Sousa NM; Laboratory of Microscopy and Microanalysis, Department of Cell Biology, University of Brasilia, Brasilia, DF, Brazil., Rampinelli PG; Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil., Silva RVS; Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil., Correa JR; Laboratory of Microscopy and Microanalysis, Department of Cell Biology, University of Brasilia, Brasilia, DF, Brazil., D'Avila H; Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Feb 23; Vol. 13, pp. 1102643. Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023).
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: Lipid Droplets*/metabolism , Tuberculosis*/metabolism, Humans ; Macrophages/microbiology ; Phagosomes/metabolism ; Lipid Metabolism ; Lipids
مستخلص: Tuberculosis (TB) is an infectious disease caused by the bacteria of the Mycobaterium tuberculosis ( Mtb ) complex. The modulation of the lipid metabolism has been implicated in the immune response regulation, including the formation of lipid droplets (LD)s, LD-phagosome association and eicosanoid synthesis. Mtb , M. bovis BCG and other pathogenic mycobacteria, as well as wall components, such as LAM, can induce LDs formation in a mechanism involving surface receptors, for instance TLRs, CD36, CD14, CD11b/CD18 and others. In addition, the activation of the lipid-activated nuclear receptor PPARγ is involved in the mechanisms of LD biogenesis, as well as in the modulation of the synthesis of lipid mediators. In infected cells, LDs are sites of compartmentalized prostaglandin E 2 synthesis involved in macrophage deactivation, bacterial replication and regulation of the host cytokine profile. LDs also have a function in vesicle traffic during infection. Rab7 and RILP, but not Rab5, are located on LDs of infected macrophages, suggesting that LDs and phagosomes could exchange essential proteins for phagosomal maturation, interfering in mycobacterial survival. The pharmacological inhibition of LDs biogenesis affects the bacterial replication and the synthesis of lipid mediators and cytokines, suggesting that LDs may be new targets for antimicrobial therapies. However, it is still controversial if the accumulation of LDs favors the mycobacterial survival acting as an escape mechanism, or promotes the host resistance to infection. Thus, in this mini-review we discuss recent advances in understanding the important role of LDs in the course of infections and the implications for the pathophysiology of mycobacteriosis.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Almeida, Pereira de Sousa, Rampinelli, Silva, Correa and D’Avila.)
References: J Leukoc Biol. 2019 Sep;106(3):563-580. (PMID: 31121077)
J Biol Chem. 1997 May 16;272(20):13326-31. (PMID: 9148954)
Front Microbiol. 2020 Jul 09;11:1394. (PMID: 32754123)
Immunology. 2002 Jun;106(2):257-66. (PMID: 12047755)
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9379-84. (PMID: 18591669)
PLoS One. 2006 Dec 20;1:e43. (PMID: 17183672)
J Immunol. 2004 Jul 1;173(1):559-65. (PMID: 15210817)
Science. 2020 Oct 16;370(6514):. (PMID: 33060333)
Front Cell Infect Microbiol. 2016 Sep 22;6:107. (PMID: 27713866)
PLoS Pathog. 2018 Jan 25;14(1):e1006874. (PMID: 29370315)
Blood. 1985 May;65(5):1269-74. (PMID: 3922452)
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1440-4. (PMID: 8381967)
Biochimie. 2017 Oct;141:54-61. (PMID: 28587792)
Front Physiol. 2021 Dec 03;12:746749. (PMID: 34925055)
Cell Biol Int. 2009 Mar;33(3):301-8. (PMID: 19114110)
Infect Immun. 2011 Aug;79(8):3291-301. (PMID: 21576327)
J Cell Biol. 2001 Mar 5;152(5):1079-85. (PMID: 11238462)
J Exp Med. 1971 Sep 1;134(3 Pt 1):713-40. (PMID: 15776571)
Cell. 1998 Apr 17;93(2):241-52. (PMID: 9568716)
Hepatology. 2015 Jun;61(6):1896-907. (PMID: 25565581)
Immunology. 2008 Oct;125(2):272-9. (PMID: 18393969)
J Immunol. 2006 Mar 1;176(5):3087-97. (PMID: 16493068)
Eur J Cell Biol. 2001 Jan;80(1):31-40. (PMID: 11211933)
Can J Microbiol. 2014 Sep;60(9):569-77. (PMID: 25113069)
Sci Signal. 2009 May 26;2(72):re3. (PMID: 19471024)
Front Cell Infect Microbiol. 2021 Oct 28;11:768124. (PMID: 34778110)
Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155. (PMID: 30523332)
Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E775-83. (PMID: 12217895)
Immunity. 1994 Sep;1(6):509-16. (PMID: 7534618)
J Biol Chem. 1999 Jun 11;274(24):16825-30. (PMID: 10358026)
Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):504-10. (PMID: 14707038)
J Lipid Res. 2007 Dec;48(12):2547-59. (PMID: 17878492)
Biophys J. 2007 Dec 1;93(11):4018-30. (PMID: 17704144)
Am J Respir Cell Mol Biol. 2007 Nov;37(5):562-70. (PMID: 17585108)
Mol Cell Biol. 2003 Sep;23(18):6494-506. (PMID: 12944476)
J Immunol. 2010 Jul 15;185(2):929-42. (PMID: 20554962)
J Exp Med. 2022 Jun 6;219(6):. (PMID: 35438721)
Microbes Infect. 2002 Jul;4(9):887-95. (PMID: 12106781)
EMBO J. 2001 Feb 15;20(4):683-93. (PMID: 11179213)
Mol Microbiol. 2022 Feb;117(2):293-306. (PMID: 34783412)
PLoS Pathog. 2020 Oct 1;16(10):e1008929. (PMID: 33002063)
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):243-50. (PMID: 20206487)
J Immunol. 2011 Sep 1;187(5):2548-58. (PMID: 21813774)
Cell Microbiol. 2011 Feb;13(2):259-73. (PMID: 20955239)
Biochim Biophys Acta. 2005 Apr 5;1728(1-2):95-104. (PMID: 15777674)
Immunol Rev. 2021 May;301(1):84-97. (PMID: 33559209)
Adv Exp Med Biol. 2013;783:103-20. (PMID: 23468106)
Biochim Biophys Acta. 1994 Apr 14;1212(1):1-25. (PMID: 8155718)
Microbes Infect. 2002 Jul;4(9):937-44. (PMID: 12106786)
Nat Immunol. 2009 Sep;10(9):943-8. (PMID: 19692995)
Curr Biol. 2001 Oct 30;11(21):1680-5. (PMID: 11696325)
J Immunol. 2009 Jul 15;183(2):1337-45. (PMID: 19561094)
Cold Spring Harb Perspect Biol. 2011 Mar 01;3(3):. (PMID: 21421923)
Nat Immunol. 2020 Mar;21(3):298-308. (PMID: 32066953)
J Atheroscler Thromb. 2012;19(2):137-48. (PMID: 22123216)
Nat Chem Biol. 2020 Feb;16(2):206-213. (PMID: 31932720)
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158703. (PMID: 32229179)
J Exp Med. 1997 Sep 15;186(6):909-20. (PMID: 9294145)
PLoS One. 2015 Aug 06;10(8):e0134317. (PMID: 26247207)
PLoS Pathog. 2011 Jun;7(6):e1002093. (PMID: 21731490)
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):450-2. (PMID: 10224472)
Mediators Inflamm. 2012;2012:478601. (PMID: 22619483)
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4376-80. (PMID: 18334639)
Science. 2019 Jun 28;364(6447):1279-1282. (PMID: 31249058)
Blood. 2007 Nov 1;110(9):3271-80. (PMID: 17664351)
J Clin Invest. 1993 May;91(5):2076-83. (PMID: 7683696)
Int Arch Allergy Immunol. 1993;101(2):136-42. (PMID: 8508051)
Biochim Biophys Acta. 2014 Jan;1841(1):97-107. (PMID: 24120921)
PLoS Pathog. 2008 Nov;4(11):e1000204. (PMID: 19002241)
Cell Microbiol. 2007 May;9(5):1087-98. (PMID: 17359235)
ACS Chem Biol. 2012 Jun 15;7(6):1095-108. (PMID: 22486388)
Biochim Biophys Acta. 2009 Nov;1791(11):1066-75. (PMID: 19573621)
Prostaglandins Leukot Essent Fatty Acids. 2011 Nov;85(5):205-13. (PMID: 21565480)
J Cell Biol. 2001 Aug 6;154(3):631-44. (PMID: 11489920)
فهرسة مساهمة: Keywords: lipid droplets; lipid metabolism; mycobacteria; phagosome; tuberculosis
المشرفين على المادة: 0 (Lipids)
تواريخ الأحداث: Date Created: 20230313 Date Completed: 20230314 Latest Revision: 20230320
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9996354
DOI: 10.3389/fcimb.2023.1102643
PMID: 36909724
قاعدة البيانات: MEDLINE
الوصف
تدمد:2235-2988
DOI:10.3389/fcimb.2023.1102643