دورية أكاديمية
Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population.
العنوان: | Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. |
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المؤلفون: | Darbas S; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Inan D; Department of Infectious Diseases, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Kilinc Y; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Arslan HS; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Ucar F; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Boylubay O; Isparta Provincial Health Directorate Central Community Health Center, Isparta, Turkiye., Koksoy S; Department of Medical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Mutlu E; Department of Medical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Yucel B; Department of Medical Biology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkiye., Ekinci NS; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye. |
المصدر: | Northern clinics of Istanbul [North Clin Istanb] 2022 Dec 13; Vol. 10 (1), pp. 67-73. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kare Publishing Country of Publication: Turkey NLM ID: 101684520 Publication Model: eCollection Cited Medium: Internet ISSN: 2536-4553 (Electronic) Linking ISSN: 25364553 NLM ISO Abbreviation: North Clin Istanb Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Istanbul, Turkey : Kare Publishing, [2014]- |
مستخلص: | Objective: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye. Methods: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing. Results: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant. Conclusion: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection. Competing Interests: No conflict of interest was declared by the authors. (© Copyright 2023 by Istanbul Provincial Directorate of Health.) |
References: | AIDS. 2014 Apr 24;28(7):959-67. (PMID: 24566094) Afr Health Sci. 2013 Jun;13(2):301-10. (PMID: 24235928) HIV Med. 2010 Mar;11(3):187-92. (PMID: 19780860) Nat Med. 1995 Jan;1(1):59-64. (PMID: 7584954) Immunity. 2012 Sep 21;37(3):426-40. (PMID: 22999948) Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2709-14. (PMID: 10694578) Science. 1999 Mar 12;283(5408):1748-52. (PMID: 10073943) Int J Rheum Dis. 2012 Dec;15(6):538-45. (PMID: 23253237) Arch Med Res. 2011 May;42(4):305-10. (PMID: 21820609) Nat Med. 1996 Apr;2(4):405-11. (PMID: 8597949) J Virol. 2010 Oct;84(19):9879-88. (PMID: 20660184) AIDS Res Ther. 2015 Aug 19;12:28. (PMID: 26300948) J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):659-70. (PMID: 15167284) J Virol. 2012 May;86(9):5230-43. (PMID: 22379086) J Immunol. 2014 Jun 1;192(11):4967-76. (PMID: 24790147) BMC Infect Dis. 2017 Apr 11;17(1):256. (PMID: 28399804) J Infect Dis. 2008 Feb 15;197(4):563-71. (PMID: 18275276) N Engl J Med. 1998 Mar 26;338(13):853-60. (PMID: 9516219) Nature. 2004 Dec 9;432(7018):769-75. (PMID: 15592417) N Engl J Med. 2003 Dec 11;349(24):2283-5. (PMID: 14668451) Science. 2010 Dec 10;330(6010):1551-7. (PMID: 21051598) Clin Exp Immunol. 1992 Jan;87(1):20-3. (PMID: 1733633) J Immunol. 1999 Jun 1;162(11):6942-6. (PMID: 10352317) Gene. 2016 Jul 25;586(2):263-7. (PMID: 27063556) J Int AIDS Soc. 2014 Nov 02;17(4 Suppl 3):19684. (PMID: 25397434) J Infect Dis. 2000 Nov;182(5):1523-6. (PMID: 11010837) J Virol. 2012 Oct;86(19):10505-16. (PMID: 22811521) Mikrobiyol Bul. 2016 Oct;50(4):544-551. (PMID: 28124959) Rheumatol Int. 2012 Apr;32(4):1003-7. (PMID: 21246357) Br J Haematol. 1990 Aug;75(4):531-6. (PMID: 2207004) Croat Med J. 2008 Jun;49(3):423-35. (PMID: 18581623) |
فهرسة مساهمة: | Keywords: Antiretroviral therapy; HIV; HLA-B alleles distribution; hypersensitivity reaction |
تواريخ الأحداث: | Date Created: 20230313 Latest Revision: 20230314 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9996654 |
DOI: | 10.14744/nci.2021.00018 |
PMID: | 36910436 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2536-4553 |
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DOI: | 10.14744/nci.2021.00018 |