تقرير
Brain tuberculoma in pediatric heart transplant recipient.
| العنوان: | Brain tuberculoma in pediatric heart transplant recipient. |
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| المؤلفون: | de Oliveira PC; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Braz Corbi MJA; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Siqueira AWDS; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Navajasegaran J; Oxford University, Oxford, UK., Mesquita ASS; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Frassetto FP; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Jatene MB; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Ikari NM; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil., Azeka E; Heart Institute (InCor) University of Sao Paulo Medical School, Sao Paulo, Brazil. |
| المصدر: | Pediatric transplantation [Pediatr Transplant] 2023 Jun; Vol. 27 (4), pp. e14496. Date of Electronic Publication: 2023 Mar 14. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997- |
| مواضيع طبية MeSH: | Tuberculoma, Intracranial*/diagnosis , Tuberculoma, Intracranial*/drug therapy , Tuberculoma, Intracranial*/pathology , Tuberculosis* , Opportunistic Infections*, Female ; Humans ; Child ; Brain/diagnostic imaging ; Brain/pathology |
| مستخلص: | Introduction: Heart transplantation is the standard treatment for end-stage heart disease. Despite advances in the field, patients remain under risk of developing complications, including opportunistic infections, such as tuberculosis. We present the unprecedented case of cerebral tuberculoma in a 9-year-old heart transplant recipient. Case Scenario: A 9-year-old female child, who underwent heart transplantation in December 2020, was admitted to the emergency department in September 2021 due to headache and vomiting. She had normal vital signs and a mild left hemiparesis. Laboratory findings included lymphopenia and a low C Reactive Protein and brain images showed expansive lesions. A biopsy of the intracranial lesion was performed and anatomopathological analysis was compatible with tuberculoma. After the diagnosis was established, treatment protocol for neurotuberculosis was initiated, the patient had a satisfactory clinical evolution and was discharged 22 days after admission. Discussion: Clinical manifestation of tuberculosis usually occurs up to 6 months after transplantation, the findings are commonly atypical and symptoms may be mild. We could not find in medical literature any description of the disease in a heart transplant recipient as young as the one presented in this case report. We documented great response to treatment, even though conventional antituberculosis therapy may interfere with immunosuppression. Conclusion: Patients in the postoperative period following heart transplantation are at high risk for developing opportunistic infections such as tuberculosis, which may present with atypical symptoms. Therefore the clinician must have a high index of suspicion in order to make the correct diagnosis and promptly start treatment. (© 2023 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: pediatric heart transplantation; tuberculoma |
| تواريخ الأحداث: | Date Created: 20230314 Date Completed: 20230517 Latest Revision: 20230522 |
| رمز التحديث: | 20230522 |
| DOI: | 10.1111/petr.14496 |
| PMID: | 36918295 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3046 |
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| DOI: | 10.1111/petr.14496 |