دورية أكاديمية
Light-emitting diode (LED) photobiomodulation regulates thermogenesis and lipogenesis markers in adipose tissue and improves anthropometric and metabolic parameters in obese mice.
| العنوان: | Light-emitting diode (LED) photobiomodulation regulates thermogenesis and lipogenesis markers in adipose tissue and improves anthropometric and metabolic parameters in obese mice. |
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| المؤلفون: | Silva MCR; Graduate Program in Food and Health (Programa de Pós-Graduação em Alimentos e Saúde - PPGAS, Federal University of Minas Gerais (Universidade Federal de Minas Gerais - UFMG), Montes Claros, Minas Gerais, Brazil., Amaro LBR; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil., Lima AT; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil., Ferreira AC; Undergraduate Degree in Medicine, Unimontes, Montes Claros, Minas Gerais, Brazil., de Farias Lelis D; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil., Andrade JMO; Graduate Program in Food and Health (Programa de Pós-Graduação em Alimentos e Saúde - PPGAS, Federal University of Minas Gerais (Universidade Federal de Minas Gerais - UFMG), Montes Claros, Minas Gerais, Brazil. joao.andrade@unimontes.br.; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil. joao.andrade@unimontes.br.; Department of Nursing, State University of Montes Claros (Unimontes), Campus Universitário Prof. Darcy Ribeiro, Av. Prof. Rui Braga, s/n - Vila Mauriceia, Montes Claros, Minas Gerais, 39401-089, Brazil. joao.andrade@unimontes.br., Guimarães ALS; Graduate Program in Food and Health (Programa de Pós-Graduação em Alimentos e Saúde - PPGAS, Federal University of Minas Gerais (Universidade Federal de Minas Gerais - UFMG), Montes Claros, Minas Gerais, Brazil. andre.guimaraes@unimontes.br.; Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil. andre.guimaraes@unimontes.br.; Department of Pathophysiology, Unimontes, Montes Claros, Minas Gerais, Brazil. andre.guimaraes@unimontes.br. |
| المصدر: | Lasers in medical science [Lasers Med Sci] 2023 Mar 15; Vol. 38 (1), pp. 85. Date of Electronic Publication: 2023 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Springer Original Publication: London : Baillière Tindall, c1986- |
| مواضيع طبية MeSH: | Lipogenesis*/genetics , Diet, High-Fat*, Male ; Animals ; Mice ; Mice, Obese ; Adipose Tissue/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/pathology ; Thermogenesis ; Mice, Inbred C57BL |
| مستخلص: | To evaluate the effects of Light-Emitting Diode (LED) irradiation on the expression of thermogenesis and lipogenesis-associated markers in adipose tissue and metabolic parameters of obese mice. Twenty-four male mice were divided into four groups: i) ST fed standard diet; ii) HCD fed hyperglycemic diet; iii) LED + I fed hyperglycemic diet and irradiated with LED in the interscapular region; iv) LED + A fed hyperglycemic diet and irradiated with LED in the abdominal region. The first phase of the study comprehended the induction of obesity for 12 weeks. Next, the animals were submitted to six irradiation sessions (days 1, 3, 7, 10, 14, and 21) using a 660-nm LED (5.77 J/cm 2 at 48,1 mW/cm 2 ). Anthropometric, biochemical, and histological parameters and the expression of thermogenesis and lipogenesis-associated markers were assessed in adipose tissue. There was diminished weight gain between the HCD and LED + A groups (ST: 0.37 ± 0.65; HCD: 3.10 ± 0.89; LED + I: -1.26 ± 0.83; LED + A: -2.07 ± 1.27 g; p < 0.018). There was a 33.3% and 23.8% reduction in epidydimal adipose tissue weight and a 25% and 10.7% in the visceral adiposity for the LED + I and LED + A groups, respectively, when compared with HCD. There was a decreased accumulation of fat droplets in adipose tissue in LED + A and LED + I groups. Additionally, LED irradiation was associated with increased mRNA expression of uncoupling protein 1 (UCP1) in the brown adipose tissue (ST: 2.27 ± 0.19; HCD: 1.54 ± 0.12; LED + I: 2.44 ± 0.22; p = 0.014) and decreased fatty acid synthetase (FAS) expression in epidydimal adipose tissue (ST: 0.79 ± 0.13; HCD: 1.59 ± 0.13; LED + A: 0.85 ± 0.04; p = 0.0008). LED treatment improved anthropometric parameters, possibly associated with the histological alterations, thermogenesis and lipogenesis markers in white adipose tissue, and expression modulation in brown adipose tissue. (© 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Brown adipose tissue; Light-Emitting Diode; Lipogenesis; Obesity; Thermogenesis; White adipose tissue |
| تواريخ الأحداث: | Date Created: 20230315 Date Completed: 20230320 Latest Revision: 20230320 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10103-023-03743-z |
| PMID: | 36920639 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1435-604X |
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| DOI: | 10.1007/s10103-023-03743-z |