دورية أكاديمية
Serial Assessment of Coronary Artery Healing of a Biodegradable Polymer Drug-Eluting Stent at 1, 2, and 3 Months by Optical Coherence Tomography (OCT)-The REPAIR Trial.
| العنوان: | Serial Assessment of Coronary Artery Healing of a Biodegradable Polymer Drug-Eluting Stent at 1, 2, and 3 Months by Optical Coherence Tomography (OCT)-The REPAIR Trial. |
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| المؤلفون: | Silva GBG, Meneguz-Moreno RA, Costa R, Chamié D, Dangas G, Manica A, Arruda JA, Sousa AGMR, Feres F, Costa JR Jr; Av. Dante Pazzanese, n. 500, 04012- 909, Sao Paulo, Brazil. rmvcosta@uol.com.br. |
| المصدر: | The Journal of invasive cardiology [J Invasive Cardiol] 2023 May; Vol. 35 (5), pp. E225-E233. Date of Electronic Publication: 2023 Mar 13. |
| نوع المنشور: | Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: HMP Communications Country of Publication: United States NLM ID: 8917477 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-2501 (Electronic) Linking ISSN: 10423931 NLM ISO Abbreviation: J Invasive Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malvern, PA : HMP Communications Original Publication: [King of Prussia, PA] : Health Management Publications, [c1988- |
| مواضيع طبية MeSH: | Coronary Artery Disease*/therapy , Drug-Eluting Stents* , Diabetes Mellitus, Type 2*, Humans ; Male ; Middle Aged ; Female ; Tomography, Optical Coherence/methods ; Prospective Studies ; Treatment Outcome ; Prosthesis Design ; Stents ; Polymers |
| مستخلص: | Background: Although first-generation drug-eluting stent (DES) devices have effectively achieved their main goal of reducing restenosis, their safety has been limited by suboptimal polymer biocompatibility, delayed stent endothelialization, and local drug toxicity, which ultimately prompted the development of new-generation DES options carrying biocompatible or even biodegradable polymers. Aims: We sought to assess the vessel-healing pattern of the novel sirolimus-eluting Inspiron DES (Scitech Medical) using serial optical coherence tomography (OCT) and assuming the hypothesis that this thin-strut (75-μm), biodegradable-polymer DES promotes a faster healing, with very early strut coverage. Methods: This is a prospective, multicenter, open-label, single-arm study enrolling 68 patients who underwent percutaneous coronary intervention guided by OCT. These patients were consecutively assigned into 3 groups. The first group had its OCT imaging follow-up performed at 3 months, the second group at 2 months, and the third group at 1 month. Results: Mean age was 59.5 years, 70.6% were male, 41.2% had type 2 diabetes, and 29.4% presented with acute coronary syndrome. A total of 72 lesions were treated and 1.06 stents were implanted per patient. OCT assessment of the stents at 1, 2, and 3 months showed a strut coverage of 90.41%, 93.96%, and 97.21%, respectively (P=.04). Conclusion: The Inspiron DES showed an early strut healing pattern, with >90% of the struts covered by neointima within the first month and with almost all struts covered by the third month. |
| فهرسة مساهمة: | Keywords: bioabsorbable; polymer; stent; strut coverage; OCT |
| المشرفين على المادة: | 0 (Polymers) |
| تواريخ الأحداث: | Date Created: 20230315 Date Completed: 20230525 Latest Revision: 20240702 |
| رمز التحديث: | 20240703 |
| DOI: | 10.25270/jic/22.00349 |
| PMID: | 36920890 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-2501 |
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| DOI: | 10.25270/jic/22.00349 |