دورية أكاديمية
Comparison of genetic diversity and phylogenetic structure of BRCA1 gene of some domestic and wild sheep breeds in different countries.
| العنوان: | Comparison of genetic diversity and phylogenetic structure of BRCA1 gene of some domestic and wild sheep breeds in different countries. |
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| المؤلفون: | Nikmanesh A; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran., Esmailizadeh A; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran., Asadollahpour Nanaei H; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran., Ezedinloo L; Department of Environment (DOE), Natural History Museum & Genetic Resource, Bureau, Park Nature of Pardisan, Tehran, Iran., Asadi Fozi M; Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran. |
| المصدر: | Animal biotechnology [Anim Biotechnol] 2023 Dec; Vol. 34 (9), pp. 4746-4759. Date of Electronic Publication: 2023 Mar 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9011409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2378 (Electronic) Linking ISSN: 10495398 NLM ISO Abbreviation: Anim Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Abingdon, Oxford : Taylor & Francis Original Publication: New York, N.Y. : Marcel Dekker, c1990- |
| مواضيع طبية MeSH: | Genetic Variation*/genetics , Genes, BRCA1*, Sheep/genetics ; Animals ; Phylogeny ; Sheep, Domestic/genetics ; Haplotypes/genetics ; Nucleotides |
| مستخلص: | BRCA1 gene plays an important role in DNA damage repair, cell cycle, and transcription process regulation; hence it's called gate keeper. The current research aims to perform bioinformatics analyzes of the BRCA1 gene of different breeds of domestic and wild sheep from 49 breeds in 14 countries using the NCBI genome database. The desired sequences were aligned using MEGA11 software and a phylogenetic tree was drawn by Neighbor-Joining method. The number of mutations, nucleotide diversity, and haploid diversity were also analyzed using Dnaspv5 software. The analyses showed 296 polymorphisms, which led to the creation of 45 different haplotypes with a haplotype diversity of 0.035. Nucleotide diversity and average nucleotide differences among breeds were estimated as 0.259 and 0.052, respectively. The average genetic distance within the population of countries was calculated as 0.052. The amount of sequence conservation in this research was 0.313 on average, which indicates the high polymorphism of this gene and the emergence of new proteins. Tajima's D value in Tajima's neutrality test was -2.421, which was significant ( p < 0.05). One of the reasons for the high genetic diversity in Iran's wild sheep population is the existence of forests and open environments, which prevent genetic drift and reduce inbreeding. |
| فهرسة مساهمة: | Keywords: BRCA1 gene; Sheep; genetic diversity; phylogenetic structure |
| المشرفين على المادة: | 0 (Nucleotides) |
| تواريخ الأحداث: | Date Created: 20230317 Date Completed: 20240214 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| DOI: | 10.1080/10495398.2023.2187410 |
| PMID: | 36927261 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2378 |
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| DOI: | 10.1080/10495398.2023.2187410 |