دورية أكاديمية

Adverse pregnancy outcomes and future risk of heart failure.

التفاصيل البيبلوغرافية
العنوان: Adverse pregnancy outcomes and future risk of heart failure.
المؤلفون: Pabón MA; Division of Cardiovascular Medicine, Brigham and Women's Hospital., Misra A; Division of Cardiovascular Medicine, Brigham and Women's Hospital.; Department of Cardiology, Boston Children's Hospital., Honigberg MC; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
المصدر: Current opinion in cardiology [Curr Opin Cardiol] 2023 May 01; Vol. 38 (3), pp. 215-222. Date of Electronic Publication: 2023 Mar 01.
نوع المنشور: Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams and Wilkins Country of Publication: United States NLM ID: 8608087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-7080 (Electronic) Linking ISSN: 02684705 NLM ISO Abbreviation: Curr Opin Cardiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia Pa : Lippincott Williams and Wilkins
Original Publication: London ; New York : Gower Academic Journals, c1986-
مواضيع طبية MeSH: Heart Failure*/etiology , Heart Failure*/complications , Cardiovascular Diseases*/etiology, Infant, Newborn ; Pregnancy ; Female ; Humans ; Pregnancy Outcome ; Placenta ; Risk Factors
مستخلص: Purpose of Review: Cardiovascular disease (CVD) is the leading cause of death in women. Women with history of adverse pregnancy outcomes (APOs) have approximately two-fold risk of future CVD, but until recently the association with future heart failure (HF) was unclear. Here, we summarize evidence for associations of APOs with HF, potential underlying mechanisms, and future directions for clinical translation.
Recent Findings: Women with history of hypertensive disorders of pregnancy (HDPs) have roughly two-fold risk of future HF compared with other parous women even after accounting for interval development of coronary artery disease. The HDPs portend heightened risk of HF with both reduced and preserved ejection fraction. Gestational diabetes mellitus (GDM) and other APOs such as preterm delivery, small-for-gestational-age delivery, and placental abruption may also confer additional risk for HF development. Possible underlying mechanisms linking APOs to HF include shared upstream risk factors and genetics, accelerated development of cardiometabolic risk factors postpartum, persistent endothelial and microvascular dysfunction, and impaired natriuretic peptide signaling.
Summary: History of APOs, including HDPs and GDM, confer increased risk for development of HF years after delivery. Further research is needed to define strategies to optimize prepregnancy and postpartum cardiovascular health toward HF prevention.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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معلومات مُعتمدة: K08 HL166687 United States HL NHLBI NIH HHS
تواريخ الأحداث: Date Created: 20230317 Date Completed: 20230406 Latest Revision: 20230511
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10079602
DOI: 10.1097/HCO.0000000000001035
PMID: 36927985
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-7080
DOI:10.1097/HCO.0000000000001035