دورية أكاديمية
أعرض في EDS

Inverse salt sensitivity in normotensive adults: role of demographic factors.

التفاصيل البيبلوغرافية
العنوان: Inverse salt sensitivity in normotensive adults: role of demographic factors.
المؤلفون: Romberger NT; Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA., Stock JM, Patik JC, McMillan RK, Lennon SL, Edwards DG, Farquhar WB
المصدر: Journal of hypertension [J Hypertens] 2023 Jun 01; Vol. 41 (6), pp. 934-940. Date of Electronic Publication: 2023 Mar 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE
أسماء مطبوعة: Publication: [Alphen aan den Rijn, the Netherlands] : Wolters Kluwer Health, Inc.
Original Publication: London ; New York : Gower Academic Pub., [1983-
مواضيع طبية MeSH: Hypertension*, Adult ; Humans ; Female ; Young Adult ; Middle Aged ; Blood Pressure/physiology ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride ; Sodium ; Demography
مستخلص: Background: Salt sensitivity and inverse salt sensitivity [ISS; a reduction in blood pressure (BP) on a high sodium diet] are each associated with increased incidence of hypertension. The purpose of this analysis was to determine the prevalence of ISS in normotensive adults and whether ISS is associated with any demographic characteristic(s).
Methods: Healthy normotensive, nonobese adults [ n  = 84; 43 women; age = 37 ± 13 years; baseline mean arterial pressure (MAP) = 89 ± 8 mmHg] participated in a controlled feeding study, consuming 7-day low-sodium (20 mmol sodium/day) and high-sodium (300 mmol sodium/day) diets. Twenty-four-hour ambulatory BP was assessed on the last day of each diet. ISS was defined as a reduction in 24-h MAP more than 5 mmHg, salt sensitivity as an increase in MAP more than 5 mmHg and salt resistance as a change in MAP between -5 and 5 mmHg from low sodium to high sodium.
Results: Using this cutoff, 10.7% were ISS, 76.2% salt resistant, and 13.1% salt sensitive. Prevalence of ISS was similar between sexes and age groups ( P  > 0.05). However, ISS was more prevalent in those with normal BMI (15.8% ISS) compared with those with overweight BMI (0% ISS; P  < 0.01). Interestingly, classification of participants using a salt sensitivity index (ΔMAP/Δ urinary sodium excretion) categorized 21.4% as ISS, 48.8% salt resistant, and 29.8% salt sensitive.
Conclusion: Overall, we found that the prevalence of ISS was 10.7% (5 mmHg cutoff) or 21.4% (salt sensitivity index), and that ISS was associated with lower BMI. These results highlight the importance of future work to understand the mechanisms of ISS and to standardize salt sensitivity assessment.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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معلومات مُعتمدة: R01 HL104106 United States HL NHLBI NIH HHS; R01 HL145055 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Sodium Chloride, Dietary)
451W47IQ8X (Sodium Chloride)
9NEZ333N27 (Sodium)
تواريخ الأحداث: Date Created: 20230317 Date Completed: 20230505 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC10228636
DOI: 10.1097/HJH.0000000000003413
PMID: 36928305
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5598
DOI:10.1097/HJH.0000000000003413