دورية أكاديمية
أعرض في EDS

Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma.

التفاصيل البيبلوغرافية
العنوان: Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma.
المؤلفون: Alhelf M; Biotechnology School, Nile University, Giza, Egypt.; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Giza, Egypt., Shoaib RMS; Food and Dairy Sciences and Technology Department, Faculty of Environmental Agricultural Sciences, Arish University, 45511, North Sinai, Egypt. rashashoaib83@yahoo.com., Elsaid A; Genetics Unit, Mansoura University, Children Hospital, Mansoura, Egypt., Bastawy N; Medical Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt., Elbeltagy NS; Department of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt., Salem ET; Department of Basic Science, Faculty of Physical Therapy, Horus University, Damietta, Egypt., Refaat S; Oncology Center, Mansoura University, Mansoura, Egypt., Abuelnadar EH; Department of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt.
المصدر: Molecular biology reports [Mol Biol Rep] 2023 May; Vol. 50 (5), pp. 4317-4327. Date of Electronic Publication: 2023 Mar 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Dordrecht, Boston, Reidel.
مواضيع طبية MeSH: Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/genetics, Humans ; Lymphotoxin-alpha/genetics ; Prognosis ; Case-Control Studies ; Egypt ; Genotype ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide/genetics
مستخلص: Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide in terms of mortality, and susceptibility is attributed to genetic, lifestyle, and environmental factors. Lymphotoxin alpha (LTA) has a crucial role in communicating the lymphocytes with stromal cells and provoking cytotoxic effects on the cancer cells. There are no reports on the contribution of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) gene polymorphism to HCC susceptibility. The main aim of this study is to investigate the association of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant with the HCC risk in the Egyptian population.
Methods: This case-control study included 317 participants (111 HCC patients, and 206 healthy controls). The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was assessed by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique.
Results: The frequencies of the dominant and recessive models (CA + AA; AA) of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant were statistically significant among HCC patients in comparison to controls (p = 0.01; p = 0.007; respectively). The A-allele of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant was statistically significant in HCC patients in comparison to controls (p ˂ 0.001).
Conclusion: The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was independently associated with an increased risk for hepatocellular carcinoma in the Egyptian population.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Hepatocellular carcinoma; LTA, Gene polymorphism; Lymphotoxin alpha
المشرفين على المادة: 0 (Lymphotoxin-alpha)
تواريخ الأحداث: Date Created: 20230317 Date Completed: 20230501 Latest Revision: 20230524
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10147750
DOI: 10.1007/s11033-023-08281-z
PMID: 36929286
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4978
DOI:10.1007/s11033-023-08281-z