دورية أكاديمية
Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma.
العنوان: | Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. |
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المؤلفون: | Alhelf M; Biotechnology School, Nile University, Giza, Egypt.; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Giza, Egypt., Shoaib RMS; Food and Dairy Sciences and Technology Department, Faculty of Environmental Agricultural Sciences, Arish University, 45511, North Sinai, Egypt. rashashoaib83@yahoo.com., Elsaid A; Genetics Unit, Mansoura University, Children Hospital, Mansoura, Egypt., Bastawy N; Medical Physiology Department, Faculty of Medicine, Cairo University, Giza, Egypt., Elbeltagy NS; Department of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt., Salem ET; Department of Basic Science, Faculty of Physical Therapy, Horus University, Damietta, Egypt., Refaat S; Oncology Center, Mansoura University, Mansoura, Egypt., Abuelnadar EH; Department of Laboratories, Faculty of Medicine, Mansoura University, Children Hospital, Mansoura, Egypt. |
المصدر: | Molecular biology reports [Mol Biol Rep] 2023 May; Vol. 50 (5), pp. 4317-4327. Date of Electronic Publication: 2023 Mar 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Dordrecht, Boston, Reidel. |
مواضيع طبية MeSH: | Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/genetics, Humans ; Lymphotoxin-alpha/genetics ; Prognosis ; Case-Control Studies ; Egypt ; Genotype ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide/genetics |
مستخلص: | Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide in terms of mortality, and susceptibility is attributed to genetic, lifestyle, and environmental factors. Lymphotoxin alpha (LTA) has a crucial role in communicating the lymphocytes with stromal cells and provoking cytotoxic effects on the cancer cells. There are no reports on the contribution of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) gene polymorphism to HCC susceptibility. The main aim of this study is to investigate the association of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant with the HCC risk in the Egyptian population. Methods: This case-control study included 317 participants (111 HCC patients, and 206 healthy controls). The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was assessed by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique. Results: The frequencies of the dominant and recessive models (CA + AA; AA) of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant were statistically significant among HCC patients in comparison to controls (p = 0.01; p = 0.007; respectively). The A-allele of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant was statistically significant in HCC patients in comparison to controls (p ˂ 0.001). Conclusion: The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was independently associated with an increased risk for hepatocellular carcinoma in the Egyptian population. (© 2023. The Author(s).) |
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فهرسة مساهمة: | Keywords: Hepatocellular carcinoma; LTA, Gene polymorphism; Lymphotoxin alpha |
المشرفين على المادة: | 0 (Lymphotoxin-alpha) |
تواريخ الأحداث: | Date Created: 20230317 Date Completed: 20230501 Latest Revision: 20230524 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10147750 |
DOI: | 10.1007/s11033-023-08281-z |
PMID: | 36929286 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-4978 |
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DOI: | 10.1007/s11033-023-08281-z |