دورية أكاديمية
The pro-apoptotic activity of sinueracasbanone D isolated from Sinularia Leptoclados in hepatocellular carcinoma cells.
| العنوان: | The pro-apoptotic activity of sinueracasbanone D isolated from Sinularia Leptoclados in hepatocellular carcinoma cells. |
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| المؤلفون: | Alarif WM; Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box, 80207, Jeddah, 21589, Saudi Arabia. walied1737@yahoo.com., Baamer DF; Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah, 21589, Saudi Arabia., Ghandourah MA; Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box, 80207, Jeddah, 21589, Saudi Arabia., Alorfi HS; Department of Chemistry, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah, 21589, Saudi Arabia., Alburae NA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia., Budiyanto F; Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box, 80207, Jeddah, 21589, Saudi Arabia.; National Research and Innovation Agency, Jl. M.H. Thamrin No. 8, Jakarta, 10340, Indonesia., Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. |
| المصدر: | Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Apr; Vol. 30 (19), pp. 56920-56929. Date of Electronic Publication: 2023 Mar 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013->: Berlin : Springer Original Publication: Landsberg, Germany : Ecomed |
| مواضيع طبية MeSH: | Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms* , Anthozoa* , Diterpenes*/pharmacology, Animals ; Humans ; Hep G2 Cells ; Cell Line, Tumor ; Apoptosis ; Cell Proliferation |
| مستخلص: | The soft-bodied corals of the genera Sarcophyton and Sinularia (Alcyoniidae) are known as a warehouse of casbane and cembranoid diterpenoids with remarkable antitumor effects. Two casbane-type diterpenoids (1, 2) along with four cembrane-type diterpenoids (3-6) were isolated from the diethyl ether soluble fraction of the organic extracts of the Red Sea soft corals Sinularia leptoclados and Sarcophyton glaucum, respectively. The antiproliferative activity of all isolated compounds (1-6) against three hepatocellular carcinoma cells, namely, Huh-7, SNU 499, and HepG2, along with the normal cells EA.hy 926, was evaluated. Sinueracabanone D (1) displayed a remarkable antiproliferative effect against the examined cancer cell lines, especially HepG2 cells with IC (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | G: 450 150 1442 Deanship of scientific research king Abdulaziz university |
| فهرسة مساهمة: | Keywords: Alcyoniidae; Apoptosis; Diterpenoids; Liver carcinoma; Mitochondrial dysfunction; Red Sea |
| المشرفين على المادة: | 0 (Diterpenes) |
| تواريخ الأحداث: | Date Created: 20230317 Date Completed: 20230425 Latest Revision: 20230425 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s11356-023-26466-8 |
| PMID: | 36930304 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1614-7499 |
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| DOI: | 10.1007/s11356-023-26466-8 |