دورية أكاديمية
أعرض في EDS

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy.

التفاصيل البيبلوغرافية
العنوان: Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy.
المؤلفون: Martinez VR; CEQUINOR-CONICET-CICPBA-UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv. 120 N◦ 1465, 1900, La Plata, Argentina; CIC-CONICET-UNLP, Facultad de Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina., Martins Lima A; Laboratory of Hemodynamics & Cardiovascular Technology (LHTC), Institute of Bioengineering (Bâtiment MED), Station 9, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Stergiopulos N; Laboratory of Hemodynamics & Cardiovascular Technology (LHTC), Institute of Bioengineering (Bâtiment MED), Station 9, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland., Velez Rueda JO; CIC-CONICET-UNLP, Facultad de Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina., Islas MS; Departamento de Química y Bioquímica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, 7600, Mar del Plata, Argentina., Griera M; Departamento de Fisiología, Universidad de Alcalá, Campus Universitario, 28871, Alcalá de Henares, Madrid, Spain., Calleros L; Departamento de Fisiología, Universidad de Alcalá, Campus Universitario, 28871, Alcalá de Henares, Madrid, Spain., Rodriguez Puyol M; Departamento de Fisiología, Universidad de Alcalá, Campus Universitario, 28871, Alcalá de Henares, Madrid, Spain., Jaquenod de Giusti C; CIC-CONICET-UNLP, Facultad de Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina., Portiansky EL; Laboratorio de Análisis de Imágenes-UNLP, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118, 1900, La Plata, Argentina., Ferrer EG; CEQUINOR-CONICET-CICPBA-UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv. 120 N◦ 1465, 1900, La Plata, Argentina., De Giusti V; CIC-CONICET-UNLP, Facultad de Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, Argentina. Electronic address: vdegiusti@med.unlp.edu.ar., Williams PAM; CEQUINOR-CONICET-CICPBA-UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bv. 120 N◦ 1465, 1900, La Plata, Argentina. Electronic address: williams@quimica.unlp.edu.ar.
المصدر: European journal of pharmacology [Eur J Pharmacol] 2023 May 05; Vol. 946, pp. 175654. Date of Electronic Publication: 2023 Mar 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: Antihypertensive Agents*/chemistry , Antihypertensive Agents*/pharmacology , Hypertension*/complications , Hypertension*/drug therapy , Hypertrophy, Left Ventricular*/drug therapy , Zinc*/pharmacology, Animals ; Rats ; Biphenyl Compounds/pharmacology ; Blood Pressure ; Matrix Metalloproteinase 2 ; Myocytes, Cardiac ; Rats, Inbred SHR ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use
مستخلص: Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously performed by our group using Zinc (ZnCand) as a strategy for improving its pharmacological properties. The measurements showed that ZnCand exerts a stronger interaction with the angiotensin II receptor, type 1 (AT 1 receptor), reducing oxidative stress and intracellular calcium flux, a mechanism implied in cell contraction. These results were accompanied by the reduction of the contractile capacity of mesangial cells. In vivo experiments showed that the complex causes a significant decrease in systolic blood pressure after 8 weeks of treatment in spontaneously hypertensive rats (SHR). The reduction of heart hypertrophy was evidenced by echocardiography, the histologic cross-sectional area of cardiomyocytes, collagen content, the B-type natriuretic peptide (BNP) marker and connective tissue growth factor (CTGF) and the matrix metalloproteinase 2 (MMP-2) expression. Besides, the complex restored the redox status. In this study, we demonstrated that the complexation with Zn(II) improves the antihypertensive and cardiac effects of the parental drug.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Cardiac hypertrophy; Hypertension; Oxidative stress; Zn-candesartan
المشرفين على المادة: 0 (Antihypertensive Agents)
0 (Biphenyl Compounds)
S8Q36MD2XX (candesartan)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
0 (Tetrazoles)
J41CSQ7QDS (Zinc)
تواريخ الأحداث: Date Created: 20230317 Date Completed: 20230830 Latest Revision: 20230830
رمز التحديث: 20231215
DOI: 10.1016/j.ejphar.2023.175654
PMID: 36930883
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2023.175654