دورية أكاديمية
أعرض في EDS

Emerging role of extracellular vesicles in multiple sclerosis: From cellular surrogates to pathogenic mediators and beyond.

التفاصيل البيبلوغرافية
العنوان: Emerging role of extracellular vesicles in multiple sclerosis: From cellular surrogates to pathogenic mediators and beyond.
المؤلفون: Palacio PL; Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital, Columbus, OH, USA., Pleet ML; Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Reátegui E; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA., Magaña SM; Department of Pediatrics, Division of Neurology, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: Setty.Magana@nationwidechildrens.org.
المصدر: Journal of neuroimmunology [J Neuroimmunol] 2023 Apr 15; Vol. 377, pp. 578064. Date of Electronic Publication: 2023 Mar 11.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
مواضيع طبية MeSH: Multiple Sclerosis*/diagnosis , Multiple Sclerosis*/therapy , Extracellular Vesicles*, Humans ; Central Nervous System ; Biomarkers ; Cell Communication
مستخلص: Multiple Sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system (CNS) driven by a complex interplay of genetic and environmental factors. While the therapeutic arsenal has expanded significantly for management of relapsing forms of MS, treatment of individuals with progressive MS is suboptimal. This treatment inequality is in part due to an incomplete understanding of pathomechanisms at different stages of the disease-underscoring the critical need for new biomarkers. Extracellular vesicles (EVs) and their bioactive cargo have emerged as endogenous nanoparticles with great theranostic potential-as diagnostic and prognostic biomarkers and ultimately as therapeutic candidates for precision nanotherapeutics. The goals of this review are to: 1) summarize the current data investigating the role of EVs and their bioactive cargo in MS pathogenesis, 2) provide a high level overview of advances and challenges in EV isolation and characterization for translational studies, and 3) conclude with future perspectives on this evolving field.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: K12 NS098482 United States NS NINDS NIH HHS; U18 TR003807 United States TR NCATS NIH HHS; UG3 TR002884 United States TR NCATS NIH HHS; UH3 TR002884 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Exosomes; Extracellular vesicles; Multiple sclerosis; Non-coding RNA; miRNA
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20230319 Date Completed: 20230404 Latest Revision: 20240416
رمز التحديث: 20240416
مُعرف محوري في PubMed: PMC10124134
DOI: 10.1016/j.jneuroim.2023.578064
PMID: 36934525
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8421
DOI:10.1016/j.jneuroim.2023.578064