دورية أكاديمية
أعرض في EDS

Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia.

التفاصيل البيبلوغرافية
العنوان: Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia.
المؤلفون: Allahyani M; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Alshalawi AM; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Alshalawii MR; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Alqorashi SA; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Aljuaid A; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Almehmadi MM; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Bokhary MA; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Albrgey AS; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Alghamdi AA; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Aldairi AF; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia., Alhazmi AS; From the Department of Clinical Laboratory Sciences (Allahyani, Alshalawi, Alshalawii, Alqorashi, Aljuaid, Almehmadi, Alghamdi, Alhazmi), College of Applied Medical Sciences, Taif University, from the Department of Clinical Chemistry (Bokhar); from the Department of Endocrinology and Diabetic Centre (Albrgey), King Abdulaziz specialist hospital, Ministry of Health, Taif, and from the Department of Laboratory Medicine (Aldairi), Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
المصدر: Saudi medical journal [Saudi Med J] 2023 Mar; Vol. 44 (3), pp. 296-305.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation Country of Publication: Saudi Arabia NLM ID: 7909441 Publication Model: Print Cited Medium: Internet ISSN: 1658-3175 (Electronic) Linking ISSN: 03795284 NLM ISO Abbreviation: Saudi Med J Subsets: MEDLINE
أسماء مطبوعة: Publication: Riyadh : Medical Services Department, Saudi Arabian Armed Forces, Ministry Of Defence And Aviation
Original Publication: Riyadh, Saudi Arabia, Riyadh Al-Kharj Hospital Programme.
مواضيع طبية MeSH: Monocytes* , Diabetes Mellitus, Type 2*/metabolism, Humans ; Case-Control Studies ; Saudi Arabia ; B-Lymphocytes/metabolism ; Flow Cytometry
مستخلص: Objectives: To evaluate the levels of total lymphocytes, B-lymphocytes (CD19+), T-lymphocytes (CD3+), natural killer (NK) cells (CD3-/CD56+), and monocyte subsets in type 2 diabetes mellitus (T2DM) patients in Saudi Arabia. In addition, this study aimed to evaluate whether B- and T-lymphocyte subsets are frequently altered in patients with T2DM.
Methods: A case-control study included 95 participants recruited in the study: 62 patients with T2DM and 33 healthy individuals. All the patients were admitted to the Diabetic Centre in Taif, Saudi Arabia. Blood samples were collected between April and August 2022. The hemoglobin A1c (HbA1c) level was evaluated in all patients. Flow cytometry was used to measure the expression of B-lymphocyte, T-lymphocyte, NK cells, and monocyte markers. The unpaired t-test was carried out to evaluate the differences in these markers between T2DM patients and healthy individuals.
Results: Patients with T2DM were associated with a lower percentage of total lymphocytes, higher percentage of B-lymphocytes, naive, and memory B subsets. In addition, patients with T2DM showed lower percentage of total T-lymphocytes (CD3+) and CD4 T-cells, but higher CD8 T-cell expression. Also, the NK-cell level was reduced in patients with T2DM, and the levels of monocyte subsets were altered.
Conclusion: These data suggested that levels of lymphocytes and monocytes are impaired in T2DM patients, and this might be associated with the higher risk of infections observed in these patients.
(Copyright: © Saudi Medical Journal.)
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فهرسة مساهمة: Keywords: T2DM; lymphocytes; monocytes
تواريخ الأحداث: Date Created: 20230320 Date Completed: 20230322 Latest Revision: 20231216
رمز التحديث: 20231216
مُعرف محوري في PubMed: PMC10043885
DOI: 10.15537/smj.2023.44.3.20220873
PMID: 36940958
قاعدة البيانات: MEDLINE
الوصف
تدمد:1658-3175
DOI:10.15537/smj.2023.44.3.20220873