دورية أكاديمية
CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands.
العنوان: | CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands. |
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المؤلفون: | Rouillon C; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Eckhardt BV; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Kollenstart L; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., Gruss F; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Verkennis AEE; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Rondeel I; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Krijger PHL; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Ricci G; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Biran A; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., van Laar T; Kavli Institute of Nanoscience Delft, TU Delft, The Netherlands., Delvaux de Fenffe CM; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Luppens G; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Albanese P; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands., Sato K; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Scheltema RA; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands., de Laat W; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Knipscheer P; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Dekker NH; Kavli Institute of Nanoscience Delft, TU Delft, The Netherlands., Groth A; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., Mattiroli F; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands. |
المصدر: | Nucleic acids research [Nucleic Acids Res] 2023 May 08; Vol. 51 (8), pp. 3770-3792. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd. |
مواضيع طبية MeSH: | Histones*/metabolism , Chromatin*/genetics, Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Chromatin Assembly Factor-1/genetics ; Chromatin Assembly Factor-1/metabolism ; DNA Replication ; DNA/genetics |
مستخلص: | During every cell cycle, both the genome and the associated chromatin must be accurately replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions in relation to the DNA replication machinery is unknown. Here, we reveal that this crosstalk differs between the leading and lagging strand at replication forks. Using biochemical reconstitutions, we show that DNA and histones promote CAF-1 recruitment to its binding partner PCNA and reveal that two CAF-1 complexes are required for efficient nucleosome assembly under these conditions. Remarkably, in the context of the replisome, CAF-1 competes with the leading strand DNA polymerase epsilon (Polϵ) for PCNA binding. However, CAF-1 does not affect the activity of the lagging strand DNA polymerase Delta (Polδ). Yet, in cells, CAF-1 deposits newly synthesized histones equally on both daughter strands. Thus, on the leading strand, chromatin assembly by CAF-1 cannot occur simultaneously to DNA synthesis, while on the lagging strand these processes may be coupled. We propose that these differences may facilitate distinct parental histone recycling mechanisms and accommodate the inherent asymmetry of DNA replication. (© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
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المشرفين على المادة: | 0 (Histones) 0 (Proliferating Cell Nuclear Antigen) 0 (Chromatin Assembly Factor-1) 0 (Chromatin) 9007-49-2 (DNA) |
تواريخ الأحداث: | Date Created: 20230321 Date Completed: 20230509 Latest Revision: 20230510 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10164577 |
DOI: | 10.1093/nar/gkad171 |
PMID: | 36942484 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1362-4962 |
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DOI: | 10.1093/nar/gkad171 |