دورية أكاديمية
أعرض في EDS

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands.

التفاصيل البيبلوغرافية
العنوان: CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands.
المؤلفون: Rouillon C; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Eckhardt BV; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Kollenstart L; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., Gruss F; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Verkennis AEE; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Rondeel I; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Krijger PHL; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Ricci G; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Biran A; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., van Laar T; Kavli Institute of Nanoscience Delft, TU Delft, The Netherlands., Delvaux de Fenffe CM; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Luppens G; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands., Albanese P; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands., Sato K; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Scheltema RA; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands., de Laat W; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Knipscheer P; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Dekker NH; Kavli Institute of Nanoscience Delft, TU Delft, The Netherlands., Groth A; Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark.; Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark., Mattiroli F; Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.
المصدر: Nucleic acids research [Nucleic Acids Res] 2023 May 08; Vol. 51 (8), pp. 3770-3792.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Histones*/metabolism , Chromatin*/genetics, Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Chromatin Assembly Factor-1/genetics ; Chromatin Assembly Factor-1/metabolism ; DNA Replication ; DNA/genetics
مستخلص: During every cell cycle, both the genome and the associated chromatin must be accurately replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions in relation to the DNA replication machinery is unknown. Here, we reveal that this crosstalk differs between the leading and lagging strand at replication forks. Using biochemical reconstitutions, we show that DNA and histones promote CAF-1 recruitment to its binding partner PCNA and reveal that two CAF-1 complexes are required for efficient nucleosome assembly under these conditions. Remarkably, in the context of the replisome, CAF-1 competes with the leading strand DNA polymerase epsilon (Polϵ) for PCNA binding. However, CAF-1 does not affect the activity of the lagging strand DNA polymerase Delta (Polδ). Yet, in cells, CAF-1 deposits newly synthesized histones equally on both daughter strands. Thus, on the leading strand, chromatin assembly by CAF-1 cannot occur simultaneously to DNA synthesis, while on the lagging strand these processes may be coupled. We propose that these differences may facilitate distinct parental histone recycling mechanisms and accommodate the inherent asymmetry of DNA replication.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)
References: Sci Rep. 2017 Apr 18;7:46274. (PMID: 28418026)
Cell Cycle. 2007 Dec 1;6(23):2962-9. (PMID: 18156805)
Nat Commun. 2020 Feb 28;11(1):1109. (PMID: 32111820)
J Biol Chem. 1991 Jun 25;266(18):12041-7. (PMID: 2050697)
Mol Cell. 2021 Jun 17;81(12):2533-2548.e9. (PMID: 33857403)
Trends Genet. 2021 Apr;37(4):317-336. (PMID: 33041047)
Nat Rev Genet. 2021 Jun;22(6):379-392. (PMID: 33500558)
Mol Cell. 2003 Feb;11(2):341-51. (PMID: 12620223)
Crit Rev Biochem Mol Biol. 2020 Oct;55(5):469-481. (PMID: 32883112)
Mol Cell. 2014 Nov 20;56(4):551-63. (PMID: 25449133)
EMBO J. 2000 Jul 17;19(14):3811-21. (PMID: 10899134)
J Biol Chem. 2012 Nov 9;287(46):39216-23. (PMID: 22989887)
Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30344-30353. (PMID: 33203675)
J Cell Biol. 2014 Jan 6;204(1):29-43. (PMID: 24379417)
Nucleic Acids Res. 2019 Feb 28;47(4):1977-1986. (PMID: 30605530)
Nature. 2022 Jun;606(7912):204-210. (PMID: 35585232)
Nucleic Acids Res. 2007;35(19):6588-97. (PMID: 17905813)
Nat Struct Mol Biol. 2014 Jan;21(1):49-55. (PMID: 24292646)
Front Cell Dev Biol. 2021 Apr 20;9:654915. (PMID: 33959610)
Mol Cell. 2008 Apr 25;30(2):137-44. (PMID: 18439893)
Nat Struct Mol Biol. 2008 Sep;15(9):972-9. (PMID: 19172751)
Cell. 1999 Feb 19;96(4):575-85. (PMID: 10052459)
J Biol Chem. 1991 Nov 25;266(33):22689-97. (PMID: 1682321)
EMBO J. 2018 Oct 1;37(19):. (PMID: 30104407)
Mol Cell Biol. 2002 Jan;22(2):614-25. (PMID: 11756556)
Genes Dev. 1997 Feb 1;11(3):345-57. (PMID: 9030687)
Nat Struct Mol Biol. 2015 Mar;22(3):192-198. (PMID: 25664722)
Curr Genet. 2021 Feb;67(1):129-139. (PMID: 33025160)
Mol Cell. 2017 Jan 5;65(1):105-116. (PMID: 27989442)
Cell. 1977 Nov;12(3):795-804. (PMID: 411576)
EMBO Rep. 2021 Apr 7;22(4):e51749. (PMID: 33619839)
Cell. 2016 Apr 21;165(3):580-92. (PMID: 27062929)
Annu Rev Biochem. 2017 Jun 20;86:417-438. (PMID: 28301743)
J Biol Chem. 2000 May 12;275(19):14541-9. (PMID: 10799539)
Mol Cell. 2018 Oct 4;72(1):112-126.e5. (PMID: 30217558)
Nucleic Acids Res. 1990 Oct 11;18(19):5767-74. (PMID: 2216769)
Methods Enzymol. 2004;375:23-44. (PMID: 14870657)
Cancer Res. 2014 Feb 1;74(3):765-74. (PMID: 24335960)
Genetics. 2016 Jul;203(3):1027-67. (PMID: 27384026)
Mol Cell. 2020 Jun 4;78(5):926-940.e13. (PMID: 32369734)
Nat Commun. 2022 Apr 29;13(1):2350. (PMID: 35487911)
Nat Cell Biol. 2020 Apr;22(4):361-371. (PMID: 32231312)
Mol Cell. 2019 Jul 25;75(2):284-297.e6. (PMID: 31126739)
Mol Cell Biol. 2000 Feb;20(4):1206-18. (PMID: 10648606)
Nature. 2015 Mar 26;519(7544):431-5. (PMID: 25739503)
Mol Cell. 2020 Feb 20;77(4):857-874.e9. (PMID: 31883950)
Science. 2018 Apr 27;360(6387):423-427. (PMID: 29700264)
Nature. 2015 Dec 10;528(7581):218-24. (PMID: 26659182)
Cancer Cell. 2018 Nov 12;34(5):707-723.e7. (PMID: 30423293)
Mol Cell. 2019 Jun 6;74(5):1020-1036.e8. (PMID: 31029541)
Elife. 2017 Mar 18;6:. (PMID: 28315523)
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4141-4146. (PMID: 28373564)
Science. 2018 Sep 28;361(6409):1389-1392. (PMID: 30115746)
Nat Chem Biol. 2018 May;14(5):431-441. (PMID: 29581585)
Nat Struct Mol Biol. 2015 Dec;22(12):976-82. (PMID: 26524492)
J Mol Biol. 1996 May 3;258(2):224-39. (PMID: 8627621)
Mol Cell. 2020 May 21;78(4):725-738.e4. (PMID: 32277910)
Cell. 1996 Sep 20;86(6):887-96. (PMID: 8808624)
Nucleic Acids Res. 2018 Nov 2;46(19):9907-9917. (PMID: 30239791)
Elife. 2016 Sep 30;5:. (PMID: 27690308)
Nat Struct Mol Biol. 2014 Aug;21(8):664-70. (PMID: 24997598)
Science. 2018 Sep 28;361(6409):1386-1389. (PMID: 30115745)
Curr Biol. 2014 May 19;24(10):R435-44. (PMID: 24845676)
Nature. 2016 Jun 30;534(7609):714-718. (PMID: 27338793)
Bio Protoc. 2018 Feb 5;8(3):. (PMID: 29516027)
PLoS Genet. 2006 Nov 3;2(11):e181. (PMID: 17083276)
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15390-5. (PMID: 25313033)
Nat Chem Biol. 2010 Apr;6(4):270-2. (PMID: 20208521)
Cell. 1989 Jul 14;58(1):15-25. (PMID: 2546672)
Nucleic Acids Res. 2019 Dec 2;47(21):11114-11131. (PMID: 31586391)
Sci Adv. 2020 Aug 26;6(35):eabb5820. (PMID: 32923642)
Cell. 2019 Oct 31;179(4):953-963.e11. (PMID: 31675501)
Genes Dev. 2015 Mar 15;29(6):585-90. (PMID: 25792596)
Cell. 1995 Jun 30;81(7):1105-14. (PMID: 7600578)
Mol Cell Biol. 2009 Dec;29(24):6353-65. (PMID: 19822659)
Dev Biol. 2007 Nov 1;311(1):213-22. (PMID: 17916346)
Science. 2017 Jan 27;355(6323):415-420. (PMID: 28126821)
Nucleic Acids Res. 2016 Jun 20;44(11):5083-94. (PMID: 26908650)
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14118-23. (PMID: 25228764)
Nat Commun. 2018 Nov 29;9(1):5061. (PMID: 30498216)
Methods Enzymol. 2016;573:3-41. (PMID: 27372747)
Nature. 2012 Mar 14;483(7390):434-8. (PMID: 22419157)
Mol Cell. 2018 Oct 4;72(1):140-151.e3. (PMID: 30244834)
Elife. 2017 Mar 18;6:. (PMID: 28315525)
Mol Cell. 2011 Dec 23;44(6):928-41. (PMID: 22195966)
Bioessays. 2018 Mar;40(3):. (PMID: 29405332)
Nat Protoc. 2021 Sep;16(9):4446-4493. (PMID: 34363071)
Chromosoma. 2009 Apr;118(2):235-48. (PMID: 19066929)
Sci Adv. 2021 Sep 24;7(39):eabf8653. (PMID: 34559566)
EMBO J. 2001 Dec 17;20(24):7294-302. (PMID: 11743005)
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):675-680. (PMID: 28069954)
Nat Cell Biol. 2019 Mar;21(3):311-318. (PMID: 30804502)
Trends Biochem Sci. 2016 Oct;41(10):859-871. (PMID: 27555051)
Cell. 1996 Oct 4;87(1):95-104. (PMID: 8858152)
Nat Commun. 2018 Dec 21;9(1):5447. (PMID: 30575763)
Nature. 2000 Nov 9;408(6809):221-5. (PMID: 11089978)
Cell. 2007 May 18;129(4):665-79. (PMID: 17512402)
Cancer Res. 2004 Apr 1;64(7):2371-81. (PMID: 15059888)
Int J Mol Sci. 2022 Sep 21;23(19):. (PMID: 36232396)
EMBO J. 2004 Sep 1;23(17):3516-26. (PMID: 15306854)
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12183-8. (PMID: 14519857)
J Mol Biol. 1986 May 5;189(1):189-204. (PMID: 3023620)
المشرفين على المادة: 0 (Histones)
0 (Proliferating Cell Nuclear Antigen)
0 (Chromatin Assembly Factor-1)
0 (Chromatin)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20230321 Date Completed: 20230509 Latest Revision: 20230510
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10164577
DOI: 10.1093/nar/gkad171
PMID: 36942484
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkad171