دورية أكاديمية
Identifying a urinary peptidomics profile for hypertension in young adults: The African-PREDICT study: Urinary peptidomics and hypertension: Urinary peptidomics and hypertension.
العنوان: | Identifying a urinary peptidomics profile for hypertension in young adults: The African-PREDICT study: Urinary peptidomics and hypertension: Urinary peptidomics and hypertension. |
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المؤلفون: | De Beer D; Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Schutte AE; Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.; School of Population Health, The George Institute for Global Health, University of New South Wales, Sydney, Australia., Delles C; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Mary S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Mullen W; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Latosinska A; Mosaiques Diagnostics GmbH, Hannover, Germany., Mischak H; Mosaiques Diagnostics GmbH, Hannover, Germany., Kruger R; Hypertension in Africa Research Team (HART), North-West University (Potchefstroom Campus), Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. |
المصدر: | Proteomics [Proteomics] 2023 Jun; Vol. 23 (11), pp. e2200444. Date of Electronic Publication: 2023 Apr 03. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, |
مواضيع طبية MeSH: | Proteomics*/methods , Hypertension*, Humans ; Male ; Young Adult ; Female ; Biomarkers ; Peptides/chemistry ; Mass Spectrometry/methods |
مستخلص: | Hypertension is one of the most important and complex risk factors for cardiovascular diseases (CVDs). By using urinary peptidomics analyses, we aimed to identify peptides associated with hypertension, building a framework for future research towards improved prediction and prevention of premature development of CVD. We included 78 hypertensive and 79 normotensive participants from the African-PREDICT study (aged 20-30 years), matched for sex (51% male) and ethnicity (49% black and 51% white). Urinary peptidomics data were acquired using capillary-electrophoresis-time-of-flight-mass-spectrometry. Hypertension-associated peptides were identified and combined into a support vector machine-based multidimensional classifier. When comparing the peptide data between the normotensive and hypertensive groups, 129 peptides were nominally differentially abundant (Wilcoxon p < 0.05). Nonetheless, only three peptides, all derived from collagen alpha-1(III), remained significantly different after rigorous adjustments for multiple comparisons. The 37 most significant peptides (all p ≤ 0.001) served as basis for the development of a classifier, with 20 peptides being combined into a unifying score, resulting in an AUC of 0.85 in the ROC analysis (p < 0.001), with 83% sensitivity at 80% specificity. Our study suggests potential value of urinary peptides in the classification of hypertension, which could enable earlier diagnosis and better understanding of the pathophysiology of hypertension and premature cardiovascular disease development. (© 2023 The Authors. Proteomics published by Wiley-VCH GmbH.) |
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معلومات مُعتمدة: | MC_PC_16095 United Kingdom MRC_ Medical Research Council; RE/18/6/34217 United Kingdom BHF_ British Heart Foundation |
فهرسة مساهمة: | Keywords: SVM; hypertension; peptidomics; proteomics |
المشرفين على المادة: | 0 (Biomarkers) 0 (Peptides) |
تواريخ الأحداث: | Date Created: 20230321 Date Completed: 20230529 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
DOI: | 10.1002/pmic.202200444 |
PMID: | 36943111 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1615-9861 |
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DOI: | 10.1002/pmic.202200444 |