دورية أكاديمية
Genotoxicity and Anticancer Effects of the Aminothiophene Derivatives SB-44, SB- 83, and SB-200 in Cancer Cells.
| العنوان: | Genotoxicity and Anticancer Effects of the Aminothiophene Derivatives SB-44, SB- 83, and SB-200 in Cancer Cells. |
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| المؤلفون: | da Silva EDL; Núcleo de Pesquisa em Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Dos Santos FA; Núcleo de Pesquisa em Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., de Oliveira JT; Laboratório de Biologia Celular e Mutagênese (LaBCeM), Campus Centro Oeste, Universidade Federal de São João del Rey, Divinópolis, MG, Brazil., Dos Santos FV; Laboratório de Biologia Celular e Mutagênese (LaBCeM), Campus Centro Oeste, Universidade Federal de São João del Rey, Divinópolis, MG, Brazil., Junior FJBM; Laboratory Synthesis and Vectoring Molecules, Departament of Biological Sciences, State University of Paraíba (UFPB), João Pessoa, PB, Brazil., do Carmo Alves de Lima M; Laboratory Synthesis and Vectoring Molecules, Departament of Biological Sciences, State University of Paraíba (UFPB), João Pessoa, PB, Brazil., da Rocha Pitta MG; Núcleo de Pesquisa em Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., de Jesus de Melo Rego MB; Núcleo de Pesquisa em Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil., Pereira MC; Núcleo de Pesquisa em Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.; Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil. |
| المصدر: | Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2023; Vol. 23 (12), pp. 1447-1456. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Bentham Science Publishers Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, [2006]- |
| مواضيع طبية MeSH: | Antineoplastic Agents*/pharmacology , Adenocarcinoma*, Male ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Cell Line ; Thiophenes/pharmacology ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor ; Drug Screening Assays, Antitumor |
| مستخلص: | Introduction: Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies have shown that thiophene derivatives have antileishmanial activity and cytotoxic activity against breast, colon, and ovarian cancer cells. Methods: In our study, we evaluated the anticancer activities of three aminothiophene derivatives: SB-44, SB-83, and SB-200, in prostate and cervical adenocarcinoma cells. Several in vitro methods were performed, including cytotoxicity, clonogenic migration, mutagenic, and cleaved Poly (ADP-ribose) polymerase (PARP) assays and annexin V staining. Results: Significant cytotoxicity was observed in cell lines with IC50 values less than 35 μM (15.38-34.04 μM). All aminothiophene derivatives significantly reduced clone formation but had no effect on cell motility. SB-83 and SB-44 induced a significant increase in the percentage of cells in the sub-G1 phase, while SB-200 derivatives significantly decreased the percentage of S/G2/M as well as induced apoptosis, with an increase of cleaved PARP. SBs compounds also showed significant mutagenic potential. Beyond that, in silico analyses revealed that all three thiophene derivatives fulfilled the criteria for oral druggability, which underscores the potential of using them in anticancer therapies. Conclusion: Our findings show that the thiophene nucleus may be used to treat solid tumors, including prostate cancer and cervical adenocarcinoma. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Anticancer effect; apoptosis; genotoxicity; proliferation; prostate cancer; thiophene |
| المشرفين على المادة: | 0 (Poly(ADP-ribose) Polymerase Inhibitors) 0 (Antineoplastic Agents) 0 (Thiophenes) |
| تواريخ الأحداث: | Date Created: 20230322 Date Completed: 20230714 Latest Revision: 20230718 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/1871520623666230321123950 |
| PMID: | 36944621 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-5992 |
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| DOI: | 10.2174/1871520623666230321123950 |