التفاصيل البيبلوغرافية
| العنوان: |
Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone. |
| المؤلفون: |
Morrison VE; Vanderbilt University Department of Biochemistry.; Vanderbilt Brain Institute.; Tulane University Center for Clinical Neuroscience Research., Houpert MG; Vanderbilt University Department of Biochemistry.; Vanderbilt Brain Institute., Trapani JB; Vanderbilt University Department of Biochemistry.; Vanderbilt Brain Institute., Brockman AA; Vanderbilt University Department of Cell and Developmental Biology.; Vanderbilt Brain Institute., Kingsley PJ; Vanderbilt University Department of Biochemistry., Katdare KA; Vanderbilt Brain Institute., Layden HM; Vanderbilt University Department of Biochemistry., Nguena-Jones G; Vanderbilt University Department of Biochemistry.; Vanderbilt Brain Institute., Trevisan AJ; Vanderbilt University Department of Biochemistry.; St. Jude Children's Research Hospital., Maguire-Zeiss KA; Georgetown University Department of Neuroscience., Marnett LJ; Vanderbilt University Department of Biochemistry.; Vanderbilt University Department of Chemistry.; Vanderbilt University Department of Pharmacology.; A.B. Hancock Jr. Memorial Laboratory for Cancer Research., Bix GJ; Tulane University Center for Clinical Neuroscience Research., Ihrie RA; Vanderbilt University Department of Cell and Developmental Biology.; Vanderbilt Brain Institute., Carter BD; Vanderbilt University Department of Biochemistry.; Vanderbilt Brain Institute. |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 06. Date of Electronic Publication: 2023 Mar 06. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment. A unique population of microglia reside in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence this neurogenic niche is not well-understood. Here, we demonstrate that phagocytosis creates a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1. Deletion of Jedi-1 decreases apoptotic cell clearance, triggering the development of a neuroinflammatory phenotype, reminiscent of neurodegenerative and-age-associated microglia, that reduces neural precursor proliferation via elevated interleukin (IL)-1β signaling; inhibition of IL-1 receptor rescues precursor proliferation in vivo . Together, these results reveal a critical role for Jedi-1 in connecting microglial phagocytic activity to a phenotype that promotes neurogenesis in the developing V-SVZ. |
| التعليقات: |
Update in: Cell Rep. 2023 Nov 10;42(11):113423. (PMID: 37952151) |
| معلومات مُعتمدة: |
R01 NS083410 United States NS NINDS NIH HHS; F32 HD107930 United States HD NICHD NIH HHS; R01 NS118580 United States NS NINDS NIH HHS; R01 NS102365 United States NS NINDS NIH HHS; T32 DK007563 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: |
Keywords: Microglia; TREM2; aging/neurodegeneration; neuroinflammation; phagocytosis; sequencing |
| تواريخ الأحداث: |
Date Created: 20230322 Latest Revision: 20240206 |
| رمز التحديث: |
20240206 |
| مُعرف محوري في PubMed: |
PMC10028845 |
| DOI: |
10.1101/2023.03.03.531012 |
| PMID: |
36945622 |
| قاعدة البيانات: |
MEDLINE |
