دورية أكاديمية
أعرض في EDS

Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood.

التفاصيل البيبلوغرافية
العنوان: Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood.
المؤلفون: Maintz L; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Schmitz MT; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Herrmann N; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Müller S; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Havenith R; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Brauer J; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland., Rhyner C; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.; DavosBioSciences, Davos, Switzerland., Dreher A; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; DavosBioSciences, Davos, Switzerland., Bersuch E; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland., Fehr D; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Hammel G; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Institute of Environmental Medicine Helmholtz Zentrum München, German Research Center for Environmental Health, Augsburg, Germany., Reiger M; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Institute of Environmental Medicine Helmholtz Zentrum München, German Research Center for Environmental Health, Augsburg, Germany., Luschkova D; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Institute of Environmental Medicine Helmholtz Zentrum München, German Research Center for Environmental Health, Augsburg, Germany., Neumann A; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Institute of Environmental Medicine Helmholtz Zentrum München, German Research Center for Environmental Health, Augsburg, Germany., Lang CCV; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland., Renner ED; Translational Immunology of Environmental Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; Department of Pediatrics, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Schmid-Grendelmeier P; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland., Traidl-Hoffmann C; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Institute of Environmental Medicine Helmholtz Zentrum München, German Research Center for Environmental Health, Augsburg, Germany., Akdis CA; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland., Lauener R; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland., Brüggen MC; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Hochgebirgsklinik Davos, Davos, Switzerland., Schmid M; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Bieber T; Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.; Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.; DavosBioSciences, Davos, Switzerland.
المصدر: Allergy [Allergy] 2023 Aug; Vol. 78 (8), pp. 2181-2201. Date of Electronic Publication: 2023 Apr 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Wiley-Blackwell
Original Publication: Copenhagen, Munksgaard.
مواضيع طبية MeSH: Dermatitis, Atopic*/etiology , Dermatitis, Atopic*/complications , Food Hypersensitivity*/complications, Infant ; Child ; Adult ; Humans ; Adolescent ; Age of Onset ; Cross-Sectional Studies ; Risk Factors
مستخلص: Background: Atopic dermatitis (AD) has long been regarded as a primarily pediatric disease. However, there is growing evidence for a high rate of adult-onset AD. We aimed to characterize factors associated with adult-onset versus childhood-onset AD and controls.
Methods: We analyzed cross-sectional data of the CK-CARE-ProRaD cohorts Bonn, Augsburg, Davos, Zürich of 736 adult patients stratified by age of AD onset (childhood-onset <18 years: 76.4% (subsets: 0 to 2; ≥2 to 6; ≥7 to 11; ≥12 to 18); adult-onset ≥18 years: 23.6% (subsets: ≥18 to 40; ≥41 to 60; ≥61) and 167 controls (91 atopic, 76 non-atopic)).
Results: We identified active smoking to be associated with adult-onset AD versus controls (adjusted Odds Ratio (aOR) = 5.54 [95% Confidence Interval: 1.06-29.01] vs. controls non-atopic , aOR = 4.03 [1.20-13.45] vs. controls atopic ). Conjunctivitis showed a negative association versus controls atopic (aOR = 0.36 [0.14-0.91]). Food allergy (aOR = 2.93 [1.44-5.96]), maternal food allergy (aOR = 9.43 [1.10-80.95]), palmar hyperlinearity (aOR = 2.11 [1.05-4.25]), and academic background (aOR = 2.14 [1.00-4.54]) increased the odds of childhood-onset AD versus controls atopic . Shared AD-associated factors were maternal AD (4-34x), increased IgE (2-20x), atopic stigmata (2-3x) with varying effect sizes depending on AD onset and control group. Patients with adult-compared to childhood-onset had doubled odds of allergic rhinitis (aOR = 2.15 [1.12-4.13]), but reduced odds to feature multiple (3-4) atopic comorbidities (aOR = 0.34 [0.14-0.84]). Adult-onset AD, particularly onset ≥61 years, grouped mainly in clusters with low contributions of personal and familial atopy and high frequencies of physical inactivity, childhood-onset AD, particularly infant-onset, mainly in "high-atopic"-clusters.
Conclusions: The identified associated factors suggest partly varying endo- and exogeneous mechanisms underlying adult-onset versus childhood-onset AD. Our findings might contribute to better assessment of the individual risk to develop AD throughout life and encourage prevention by non-smoking and physical activity as modifiable lifestyle factors.
(© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
References: Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4:1.
Abuabara K, Ye M, McCulloch CE, et al. Clinical onset of atopic eczema: results from 2 nationally representative British birth cohorts followed through midlife. J Allergy Clin Immunol. 2019;144:710-719.
Czarnowicki T, He H, Krueger JG, Guttman-Yassky E. Atopic dermatitis endotypes and implications for targeted therapeutics. J Allergy Clin Immunol. 2019;143:1-11.
Thorsteinsdottir S, Stokholm J, Thyssen JP, et al. Genetic, clinical, and environmental factors associated with persistent atopic dermatitis in childhood. JAMA Dermatol. 2019;155:50-57.
Reiger M, Traidl-Hoffmann C, Neumann AU. The skin microbiome as a clinical biomarker in atopic eczema: promises, navigation, and pitfalls. J Allergy Clin Immunol. 2020;145:93-96.
Ständer S. Atopic dermatitis. N Engl J Med. 2021;384:1136-1143.
Klaeschen AS, Nümm TJ, Herrmann N, et al. JAK1/2 inhibition impairs the development and function of inflammatory dendritic epidermal cells in atopic dermatitis. J Allergy Clin Immunol. 2020;147:2202-2212.e8.
Maintz L, Welchowski T, Herrmann N, et al. Machine learning-based deep phenotyping of atopic dermatitis: severity-associated factors in adolescent and adult patients. JAMA Dermatol. 2021;157:1414-1424.
Garmhausen D, Hagemann T, Bieber T, et al. Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy. 2013;68:498-506.
Roduit C, Frei R, Depner M, et al. Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood. JAMA Pediatr. 2017;171:655-662.
Paternoster L, Savenije OEM, Heron J, et al. Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts. J Allergy Clin Immunol. 2018;141:964-971.
Lee HH, Patel KR, Singam V, Rastogi S, Silverberg JI. A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis. J Am Acad Dermatol. 2019;80:1526-1532.e7.
Silverberg JI. Adult-onset atopic dermatitis. J Allergy Clin Immunol Pract. 2019;7:28-33.
Ingordo V, Cazzaniga S, Naldi L, et al. Atopic dermatitis in young adult italian males: persistent and adult-onset varieties did not differ clinically and as for allergological variables. G Ital Dermatol Venereol. 2019;155:724-732.
Silverberg JI, Vakharia PP, Chopra R, et al. Phenotypical differences of childhood- and adult-onset atopic dermatitis. J Allergy Clin Immunol Pract. 2018;6:1306-1312.
Silverberg JI. Atopic dermatitis in adults. Med Clin North Am. 2020;104:157-176.
Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults. Results from an International Survey. Allergy. 2018;73:1284-1293.
Abuabara K, Langan SM, Yu AM. Conclusions about atopic dermatitis persistence might be premature. J Am Acad Dermatol. 2017;76:e177-e178.
Wan J, Mitra N, Hoffstad OJ, Yan AC, Margolis DJ. Longitudinal atopic dermatitis control and persistence vary with timing of disease onset in children: a cohort study. J Am Acad Dermatol. 2019;81:1292-1299.
Kim JP, Chao LX, Simpson EL, Silverberg JI. Persistence of atopic dermatitis (AD). A systematic review and meta-analysis. J Am Acad Dermatol. 2016;75:681-687.e11.
Silverberg JI. Persistence of childhood eczema into adulthood. JAMA Dermatol. 2014;150:591-592.
Kim Y, Blomberg M, Rifas-Shiman SL, et al. Racial/ethnic differences in incidence and persistence of childhood atopic dermatitis. J Invest Dermatol. 2019;139:827-834.
Abuabara K, Yu AM, Okhovat J-P, Allen IE, Langan SM. The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal studies. Allergy. 2018;73:696-704.
Abuabara K, Margolis DJ, Langan SM. The long-term course of atopic dermatitis. Dermatol Clin. 2017;35:291-297.
Mulick AR, Mansfield KE, Silverwood RJ, et al. Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort. Br J Dermatol. 2021;185:526-536.
Abuabara K, Hoffstad O, Troxel AB, Gelfand JM, McCulloch CE, Margolis DJ. Patterns and predictors of atopic dermatitis disease control past childhood: an observational cohort study. J Allergy Clin Immunol. 2018;141:778-780.e6.
Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol. 2014;150:593-600.
Silverwood RJ, Forbes HJ, Abuabara K, et al. Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study. BMJ. 2018;361:k1786.
Zhou L, Leonard A, Pavel AB, et al. Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis. J Allergy Clin Immunol. 2019;144:144-156.
Ozkaya E. Adult-onset atopic dermatitis. J Am Acad Dermatol. 2005;52:579-582.
Wang X, Shi X-D, Li L-F, Zhou P, Shen Y-W, Song Q-K. Prevalence and clinical features of adult atopic dermatitis in tertiary hospitals of China. Medicine. 2017;96:e6317.
Wang S, Zhu R, Gu C, et al. Distinct clinical features and serum cytokine pattern of elderly atopic dermatitis in China. J Eur Acad Dermatol Venereol. 2020;34:2346-2352.
Son JH, Chung BY, Kim HO, Park CW. Clinical features of atopic dermatitis in adults are different according to onset. J Korean Med Sci. 2017;32:1360-1366.
Bieber T, Traidl-Hoffmann C, Schäppi G, Lauener R, Akdis C, Schmid-Grendlmeier P. Unraveling the Complexity of Atopic Dermatitis: the CK-CARE Approach toward Precision Medicine. Universität Augsburg; Wiley; 2020.
Husson F, Lê S, Pagès J. Exploratory Multivariate Analysis by Example Using R. CRC Press; 2017.
Pagès J. Analyse factorielle de donnees mixtes. Rev Stat Appl. 2004;52:93-111.
R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2019 https://www.R-project.org/.
Schauberger P, Walker A. openxlsx: Read, Write and Edit xlsx Files. R package version 4.1.4. 2019 https://CRAN.R-project.org/package=openxlsx.
Dowle M, Srinivasan A. Data.Table: extension of ‘data.Frame’. R package version 1.12.8. 2019 https://CRAN.R-project.org/package=data.table.
Kuhn M. Classification and regression training. R package version 6.0-86. https://CRAN.R-project.org/package=caret.
Wickham H, Bryan J. readxl: Read Excel Files. R package version 1.3.1. 2019 https://CRAN.R-project.org/package=readxl.
Fox J, Weisberg S. An {R} Companion to Applied Regression. 3rd ed. Sage; 2019 https://socialsciences.mcmaster.ca/jfox/Books/Companion/index.html.
Dragulescu A, Arendt C. xlsx: Read, Write, Format Excel 2007 and Excel 97/2000/XP/2003 Files. R package version 0.6.3. 2020 https://CRAN.R-project.org/package=xlsx.
Hothorn T, Hornik K, van de Wiel MA, Zeileis A. A Lego system for conditional inference. Am Stat. 2006;60:257-263.
Wickham H. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag; 2016.
Auguie B. gridExtra: Miscellaneous Functions for “Grid” Graphics. R package version 2.3. 2017 https://CRAN.R-project.org/package=gridExtra.
Harrell F Jr, with contributions from Charles Dupont and many others. Hmisc: Harrell Miscellaneous. R package version 4.4-0. 2020 https://CRAN.R-project.org/package=Hmisc.
Kuhn M, Johnson K. Applied Predictive Modelling. Springer Science+Business Media; 2013.
Zhang T, Yu B. Boosting with early stopping: convergence and consistency. Ann Stat. 2005;33:1538-1579.
Chen T, He T, Benesty M, et al. xgboost: Extreme Gradient Boosting. R package version 0.90.0.2. 2019 https://CRAN.R-project.org/package=xgboost.
Friedman JH. Greedy function approximation: a gradient boosting machine. Ann Stat. 2001;29:1189-1232.
Diepgen TL, Fartasch M, Hornstein OP. Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population. Acta Derm Venereol Suppl. 1989;144:50-54.
Bradshaw LE, Haines RH, Thomas KS, et al. Clinical examination for hyperlinear palms to determine filaggrin genotype: a diagnostic test accuracy study. Clin Exp Allergy. 2021;51:1421-1428.
Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66(Suppl 1):8-16.
Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol. 2002;2:372-377.
Kantor R, Kim A, Thyssen JP, Silverberg JI. Association of atopic dermatitis with smoking: a systematic review and meta-analysis. J Am Acad Dermatol. 2016;75:1119-1125.e1.
Sticozzi C, Belmonte G, Pecorelli A, et al. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS ONE. 2012;7:e33592.
Sticozzi C, Belmonte G, Frosini M, Pessina F. Correction to: nitric oxide/cyclic GMP-dependent calcium signalling mediates IL-6- and TNF-α-induced expression of glial fibrillary acid protein. J Mol Neurosci. 2021;71:867-868.
Lee CH, Chuang HY, Hong CH, et al. Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis. Br J Dermatol. 2011;164:483-489.
Morra DE, Cho E, Li T, Camargo CA, Qureshi AA, Drucker AM. Smoking and risk of adult-onset atopic dermatitis in US women. J Am Acad Dermatol. 2021;84:561-563.
Smirnova J, Montgomery S, Lindberg M, Svensson Å, von Kobyletzki L. Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study. BMC Dermatol. 2020;20:23.
Pilz AC, Schielein MC, Schuster B, et al. Atopic dermatitis: disease characteristics and comorbidities in smoking and non-smoking patients from the TREATgermany registry. J Eur Acad Dermatol Venereol. 2022;36:413-421.
Davis DMR, Drucker AM, Alikhan A, et al. AAD guidelines: awareness of comorbidities associated with atopic dermatitis in adults. J Am Acad Dermatol. 2022;86:1335-1336.e18.
Salimans L, Liberman K, Njemini R, Kortekaas Krohn I, Gutermuth J, Bautmans I. The effect of resistance exercise on the immune cell function in humans: a systematic review. Exp Gerontol. 2022;164:111822.
Morales E, Strachan D, Asher I, Ellwood P, Pearce N, Garcia-Marcos L. Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III. Thorax. 2019;74:531-538.
Strom MA, Silverberg JI. Associations of physical activity and sedentary behavior with atopic disease in United States children. J Pediatr. 2016;174:247-253.e3.
Lonne-Rahm S-B, Sundström I, Nordlind K, Engström L-M. Adult atopic dermatitis patients and physical exercise: a Swedish questionnaire study. Acta Derm Venereol. 2014;94:185-187.
Son WK, Yoon W, Kim S, et al. Can moderate-intensity aerobic exercise ameliorate atopic dermatitis. Exp Dermatol. 2020;29:699-702.
Pennanen M, Broms U, Korhonen T, et al. Smoking, nicotine dependence and nicotine intake by socio-economic status and marital status. Addict Behav. 2014;39:1145-1151.
Sim YS, Yoo S, Lee K-S, Rhee CK, Kim YK. Associations of clinical, psychological, and socioeconomic characteristics with nicotine dependence in smokers. Sci Rep. 2021;11:18544.
Esparza-Gordillo J, Matanovic A, Marenholz I, et al. Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance. PLoS Genet. 2015;11:e1005076.
Cookson W. Genetics and genomics of asthma and allergic diseases. Immunol Rev. 2002;190:195-206.
Alduraywish SA, Lodge CJ, Campbell B, et al. The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies. Allergy. 2016;71:77-89.
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD. The atopic march and atopic multimorbidity: many trajectories, many pathways. J Allergy Clin Immunol. 2019;143:46-55.
Fukuie T, Yasuoka R, Fujiyama T, Sakabe J-I, Taguchi T, Tokura Y. Palmar hyperlinearity in early childhood atopic dermatitis is associated with filaggrin mutation and sensitization to egg. Pediatr Dermatol. 2019;36:213-218.
Rupnik H, Rijavec M, Korošec P. Filaggrin loss-of-function mutations are not associated with atopic dermatitis that develops in late childhood or adulthood. Br J Dermatol. 2015;172:455-461.
Lommatzsch M, Klein M, Stoll P, Virchow JC. Type 2 biomarker expression (FeNO and blood eosinophils) is higher in severe adult-onset than in severe early-onset asthma. Allergy. 2021;76:3199-3202.
فهرسة مساهمة: Keywords: adult-onset; associated factor; atopic dermatitis; childhood-onset; phenotype
تواريخ الأحداث: Date Created: 20230322 Date Completed: 20231023 Latest Revision: 20231025
رمز التحديث: 20231026
DOI: 10.1111/all.15721
PMID: 36946297
قاعدة البيانات: MEDLINE
الوصف
تدمد:1398-9995
DOI:10.1111/all.15721