دورية أكاديمية

Transcriptional and spatiotemporal regulation of the dauer program.

التفاصيل البيبلوغرافية
العنوان: Transcriptional and spatiotemporal regulation of the dauer program.
المؤلفون: Godoy LF; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD) Universidad Maimónides, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina., Hochbaum D; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD) Universidad Maimónides, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
المصدر: Transcription [Transcription] 2023 Nov; Vol. 14 (1-2), pp. 27-48. Date of Electronic Publication: 2023 Mar 23.
نوع المنشور: Review; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101530967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2154-1272 (Electronic) Linking ISSN: 21541272 NLM ISO Abbreviation: Transcription Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/metabolism, Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Signal Transduction ; Gene Expression Regulation ; Insulin/metabolism
مستخلص: Caenorhabditis elegans can enter a diapause stage called "dauer" when it senses that the environment is not suitable for development. This implies a detour from the typical developmental trajectory and requires a tight control of the developmental clock and a massive tissue remodeling. In the last decades, core components of the signaling pathways that govern the dauer development decision have been identified, but the tissues where they function for the acquisition of dauer-specific traits are still under intense study. Growing evidence demonstrates that these pathways engage in complex cross-talk and feedback loops. In this review, we summarize the current knowledge regarding the transcriptional regulation of the dauer program and the relevant tissues for its achievement. A better understanding of this process will provide insight on how developmental plasticity is achieved and how development decisions are under a robust regulation to ensure an all-or-nothing response. Furthermore, this developmental decision can also serve as a simplified model for relevant developmental disorders. Abbreviations: AID Auxin Induced Degron DA dafachronic acid Daf-c dauer formation constitutive Daf-d dauer formation defective DTC Distal Tip Cells ECM modified extracellular matrix GPCRs G protein-coupled receptors IIS insulin/IGF-1 signaling ILPs insulin-like peptides LBD Ligand Binding Domain PDL4 Post Dauer L4 TGF-β transforming growth factor beta WT wild-type.
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فهرسة مساهمة: Keywords: LoF loss of function
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
0 (Insulin)
تواريخ الأحداث: Date Created: 20230323 Date Completed: 20230719 Latest Revision: 20240324
رمز التحديث: 20240324
مُعرف محوري في PubMed: PMC10353326
DOI: 10.1080/21541264.2023.2190295
PMID: 36951297
قاعدة البيانات: MEDLINE
الوصف
تدمد:2154-1272
DOI:10.1080/21541264.2023.2190295