دورية أكاديمية
Fasting Glucose, Glycated Hemoglobin, and 2h Post-load Blood Glucose Are Independently Associated With Arterial Stiffness in Diabetes: The ELSA-Brasil Study.
| العنوان: | Fasting Glucose, Glycated Hemoglobin, and 2h Post-load Blood Glucose Are Independently Associated With Arterial Stiffness in Diabetes: The ELSA-Brasil Study. |
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| المؤلفون: | Pereira WDS; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, Brazil., Lelis DF; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, Brazil., Cunha RS; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brazil., Griep RH; Laboratory of Health and Environment Education, Oswaldo Cruz Institute, Rio de Janeiro, Brazil., Barreto SM; School of Medicine and Clinical Hospital/EBSERH, Federal University of Minas Gerais, Belo Horizonte, Brazil., Molina MDCB; Post Graduate Programme in Public Health, Federal University of Espírito Santo, Vitória, Brazil., Schmidt MI; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Duncan BB; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Bensenor I; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, Brazil., Lotufo PA; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, Brazil., Mill JG; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brazil., Baldo MP; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, Brazil. |
| المصدر: | Angiology [Angiology] 2024 Aug; Vol. 75 (7), pp. 635-644. Date of Electronic Publication: 2023 Mar 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 0203706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-1574 (Electronic) Linking ISSN: 00033197 NLM ISO Abbreviation: Angiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Publications Original Publication: New York [etc.] Angiology Research Foundation. |
| مواضيع طبية MeSH: | Vascular Stiffness* , Blood Glucose*/metabolism , Blood Glucose*/analysis , Glycated Hemoglobin*/metabolism , Glycated Hemoglobin*/analysis , Fasting*/blood, Humans ; Female ; Male ; Cross-Sectional Studies ; Middle Aged ; Brazil/epidemiology ; Aged ; Carotid-Femoral Pulse Wave Velocity ; Diabetes Mellitus/blood ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Adult ; Glucose Tolerance Test ; Biomarkers/blood ; Risk Factors ; Pulse Wave Analysis ; Prevalence |
| مستخلص: | The association of diabetes with increased large artery stiffness is not definitively established. We aimed to describe the carotid-femoral pulse wave velocity (cf-PWV) in participants with and without diabetes and whether the cf-PWV could vary among the different laboratory-based criteria used. A cross-sectional analysis using baseline data from 13,912 adults was used. cf-PWV as well as anthropometric, biochemical, and clinical data were measured. Diabetes was defined by previous medical diagnosis, medication use, fasting glucose, an oral glucose tolerance test (GTT), or glycated hemoglobin (HbA1c). The prevalence of diabetes was 18.7%, higher in men than in women. After adjustment, participants with diabetes showed higher cf-PWV (men: 9.7 ± 1.7 vs 9.4 ± 1.7 m/s, P < .05; women: 9.4 ± 1.6 vs 9.1 ± 1.7 m/s, P < .05). We observed a progressive increase in cf-PWV as >1 laboratory-based criterion for diabetes diagnosis was reached. Also, participants with diabetes with alterations in any laboratory-based criteria had higher cf-PWV than participants without diabetes, regardless of sex. In summary, diabetes is associated with higher cf-PWV as is each laboratory-based parameter used for its diagnosis. These results support the strong consequences of glucose dysregulation on the vascular system and provide evidence to screen all parameters involved in glycemic metabolism to improve vascular health. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| فهرسة مساهمة: | Keywords: 2h post-load blood glucose; HbA1c; arterial stiffness; diabetes; fasting glucose |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Glycated Hemoglobin) 0 (hemoglobin A1c protein, human) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230323 Date Completed: 20240619 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| DOI: | 10.1177/00033197231166180 |
| PMID: | 36951393 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1940-1574 |
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| DOI: | 10.1177/00033197231166180 |