دورية أكاديمية
Acetylcholinesterase Inhibitory Activity of Modified Lupane, Oleanane, and Ursane A-seco-Triterpenoids.
| العنوان: | Acetylcholinesterase Inhibitory Activity of Modified Lupane, Oleanane, and Ursane A-seco-Triterpenoids. |
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| المؤلفون: | Petrova AV; Ufa Institute of Chemistry of the Ufa Federal Research Center of the, Russian Academy of Sciences, 71, prospect Octyabrya, Ufa, 450054, Russian Federation., Kazakova OB; Ufa Institute of Chemistry of the Ufa Federal Research Center of the, Russian Academy of Sciences, 71, prospect Octyabrya, Ufa, 450054, Russian Federation., Nazarov IS; Ufa Institute of Chemistry of the Ufa Federal Research Center of the, Russian Academy of Sciences, 71, prospect Octyabrya, Ufa, 450054, Russian Federation., Csuk R; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120, Halle (Saale), Germany., Heise NV; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120, Halle (Saale), Germany. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2023 Apr; Vol. 20 (4), pp. e202300185. Date of Electronic Publication: 2023 Mar 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | Acetylcholinesterase*/metabolism , Triterpenes*/pharmacology, Molecular Structure ; Structure-Activity Relationship ; Lupanes ; Cholinesterase Inhibitors/pharmacology |
| مستخلص: | A series of new lupane, ursane, and oleanane type triterpenic A-seco-derivatives containing bromo-, azido-, alkyne-, 1H-tetrazol-5-yl-, 5-methyloxazol-2-yl-, N-(4-(4-methylpiperazin-1-yl)but-2-yn-1-yl), and a carbonyl group at C2, C24, C28, C30 positions has been synthesized. The bioactivity was evaluated by Ellman's method, and the results showed that most of the compounds displayed moderate acetylcholinesterase inhibitory activities in vitro. Among them, A-seco-derivatives of 28-oxo-allobetuline and betulinic acid with bromo- and azido-groups exhibited the most potent inhibitory activity against AChE. Extra experiments showed methyl 2-cyano-3,4-seco-dibromo- and 2-cyano-3,4-seco-diazido-derivatives of betulinic acid as mixed-type inhibitors, with Ki values as low as K (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | 22-73-00266 Russian Science Foundation; 1022040400061-8-1.4.1;1.4.3 Russian Science Foundation |
| فهرسة مساهمة: | Keywords: A-seco-triterpenoids; Alzheimer's disease; Beckmann rearrangement; acetylcholinesterase inhibitor; natural products |
| المشرفين على المادة: | 0 (ursane) EC 3.1.1.7 (Acetylcholinesterase) 0 (Triterpenes) 0 (oleanane) 0 (Lupanes) 0 (Cholinesterase Inhibitors) |
| تواريخ الأحداث: | Date Created: 20230324 Date Completed: 20230428 Latest Revision: 20230428 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1002/cbdv.202300185 |
| PMID: | 36960660 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202300185 |