دورية أكاديمية
Cocoa powder and fermented jackfruit seed flour: A comparative cell-based study on their potential antioxidant and anti-inflammatory activities after simulated gastrointestinal digestion.
العنوان: | Cocoa powder and fermented jackfruit seed flour: A comparative cell-based study on their potential antioxidant and anti-inflammatory activities after simulated gastrointestinal digestion. |
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المؤلفون: | Spada FP; Department of Food and Experimental Nutrition, Food Research Center (FoRC), University of São Paulo, São Paulo, Brazil.; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil., Lazarini JG; Department of Biosciences, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Faculty of Medicine, Anhembi Morumbi University, Piracicaba, Brazil., Batista PS; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., de Oliveira Sartori AG; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil., Saliba ASMC; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., Pedroso Gomes do Amaral JE; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., Purgatto E; Department of Food and Experimental Nutrition, Food Research Center (FoRC), University of São Paulo, São Paulo, Brazil., de Alencar SM; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil. |
المصدر: | Journal of the science of food and agriculture [J Sci Food Agric] 2023 Aug 15; Vol. 103 (10), pp. 4956-4965. Date of Electronic Publication: 2023 Apr 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons Original Publication: London, Society of Chemical Industry. |
مواضيع طبية MeSH: | Chocolate* , Artocarpus*/chemistry, Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/analysis ; Flour/analysis ; Tumor Necrosis Factor-alpha/genetics ; NF-kappa B/genetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/analysis ; Seeds/chemistry ; Digestion |
مستخلص: | Background: Jackfruit seed flour can be used as a cocoa aroma replacer with similar technological properties. The purpose of this study was to investigate the in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non-alkaline cocoa powder (Nac). Results: Fjs and Nac extracts (Fjs-E and Nac-E) were produced and submitted to in vitro gastrointestinal digestion producing digested fractions named Fjs-D and Nac-D, respectively. Nac-E showed over two-fold higher oxygen radical absorbance capacity (ORAC) than Fjs-E. However, after simulated gastrointestinal digestion (in vitro), there were no significant differences between Nac-D and Fjs-D (P < 0.01). Similarly, the cellular antioxidant activity (CAA) of Nac-D and Fjs-D was not significantly different (P < 0.01). The anti-inflammatory assay in transgenic RAW 264.7 murine macrophages showed that Fjs-E did not affect cell viability up to 300 μg mL -1 (P > 0.05) and reduced by 15% the release of TNF-α (P < 0.05). Fjs-D did not affect cell viability up to 300 μg mL -1 (P > 0.05) and showed 58% reduction of NF-κB activation (P < 0.05), with no effects on TNF-α levels. Treatment with Nac-E up to 300 μg mL -1 did not decrease cell viability (P > 0.05) and reduced the release of TNF-α levels by 34% and 66% at 100 and 300 μg mL -1 , respectively (P < 0.05). Nac-D did not reduce the NF-κB activation or TNF-α levels at any tested concentration. Conclusion: Collectively, these findings indicate that Fjs is a safe and promising functional ingredient with biological activities even after gastrointestinal digestion. © 2023 Society of Chemical Industry. (© 2023 Society of Chemical Industry.) |
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معلومات مُعتمدة: | This research was funded by São Paulo Research Foundation (FAPESP), grant number 2018/19494. |
فهرسة مساهمة: | Keywords: Artocarpus heterophyllus; Caco-2 cells; Galleria mellonella; RAW 264.7 cells; bioavailability |
المشرفين على المادة: | 0 (Antioxidants) 0 (Tumor Necrosis Factor-alpha) 0 (NF-kappa B) 0 (Anti-Inflammatory Agents) |
تواريخ الأحداث: | Date Created: 20230324 Date Completed: 20230608 Latest Revision: 20230608 |
رمز التحديث: | 20240628 |
DOI: | 10.1002/jsfa.12568 |
PMID: | 36960787 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-0010 |
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DOI: | 10.1002/jsfa.12568 |