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Cocoa powder and fermented jackfruit seed flour: A comparative cell-based study on their potential antioxidant and anti-inflammatory activities after simulated gastrointestinal digestion.

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العنوان: Cocoa powder and fermented jackfruit seed flour: A comparative cell-based study on their potential antioxidant and anti-inflammatory activities after simulated gastrointestinal digestion.
المؤلفون: Spada FP; Department of Food and Experimental Nutrition, Food Research Center (FoRC), University of São Paulo, São Paulo, Brazil.; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil., Lazarini JG; Department of Biosciences, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Faculty of Medicine, Anhembi Morumbi University, Piracicaba, Brazil., Batista PS; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., de Oliveira Sartori AG; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil., Saliba ASMC; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., Pedroso Gomes do Amaral JE; University of São Paulo, Center for Nuclear Energy in Agriculture (CENA), São Paulo, Brazil., Purgatto E; Department of Food and Experimental Nutrition, Food Research Center (FoRC), University of São Paulo, São Paulo, Brazil., de Alencar SM; Department of Agri-Food Industry, Food and Nutrition, University of São Paulo, Luiz de Queiroz College of Agriculture (ESALQ), São Paulo, Brazil.
المصدر: Journal of the science of food and agriculture [J Sci Food Agric] 2023 Aug 15; Vol. 103 (10), pp. 4956-4965. Date of Electronic Publication: 2023 Apr 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
مواضيع طبية MeSH: Chocolate* , Artocarpus*/chemistry, Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/analysis ; Flour/analysis ; Tumor Necrosis Factor-alpha/genetics ; NF-kappa B/genetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/analysis ; Seeds/chemistry ; Digestion
مستخلص: Background: Jackfruit seed flour can be used as a cocoa aroma replacer with similar technological properties. The purpose of this study was to investigate the in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non-alkaline cocoa powder (Nac).
Results: Fjs and Nac extracts (Fjs-E and Nac-E) were produced and submitted to in vitro gastrointestinal digestion producing digested fractions named Fjs-D and Nac-D, respectively. Nac-E showed over two-fold higher oxygen radical absorbance capacity (ORAC) than Fjs-E. However, after simulated gastrointestinal digestion (in vitro), there were no significant differences between Nac-D and Fjs-D (P < 0.01). Similarly, the cellular antioxidant activity (CAA) of Nac-D and Fjs-D was not significantly different (P < 0.01). The anti-inflammatory assay in transgenic RAW 264.7 murine macrophages showed that Fjs-E did not affect cell viability up to 300 μg mL -1 (P > 0.05) and reduced by 15% the release of TNF-α (P < 0.05). Fjs-D did not affect cell viability up to 300 μg mL -1 (P > 0.05) and showed 58% reduction of NF-κB activation (P < 0.05), with no effects on TNF-α levels. Treatment with Nac-E up to 300 μg mL -1 did not decrease cell viability (P > 0.05) and reduced the release of TNF-α levels by 34% and 66% at 100 and 300 μg mL -1 , respectively (P < 0.05). Nac-D did not reduce the NF-κB activation or TNF-α levels at any tested concentration.
Conclusion: Collectively, these findings indicate that Fjs is a safe and promising functional ingredient with biological activities even after gastrointestinal digestion. © 2023 Society of Chemical Industry.
(© 2023 Society of Chemical Industry.)
References: Pimm SL and Raven P, Extinction by numbers. Nature 403:843-845 (2000).
Hail N, Cortes M, Drake EN and Spallholz JE, Cancer chemoprevention: a radical perspective. Free Radic Biol Med 45:97-110 (2008).
Tresserra-Rimbau A, Lamuela-Raventos RM and Moreno JJ, Polyphenols, food and pharma. Current knowledge and directions for future research. Biochem Pharmacol 156:186-195 (2018).
Fraga CG and Oteiza PI, Dietary Flavonoids: role of (−)-Epicatechin and Related Procyanidins in Cell Signaling, Vol. 51. Free Radical Biol Med, pp. 813-823 (2011). https://linkinghub.elsevier.com/retrieve/pii/S0891584911003601.
Martín MA and Ramos S, Cocoa polyphenols in oxidative stress: potential health implications. J Funct Foods 27:570-588 (2016).
Bordiga M, Locatelli M, Travaglia F, Co JD and Mazza G, Evaluation of the effect of processing on cocoa polyphenols: antiradical activity, anthocyanins and procyanidins profiling from raw beans to chocolate. Int J Food Sci Technol 50:840-848 (2015).
Delgado-Ospina J, Di Mattia CD, Paparella A, Mastrocola D, Martuscelli M and Chaves-Lopez C, Effect of fermentation, drying and roasting on Colombian criollo cocoa beans and shells. Foods 9:520 (2020).
Martini S, Conte A and Tagliazucchi D, Bioaccessibility, bioactivity and cell metabolism of dark chocolate phenolic compounds after in vitro gastro-intestinal digestion. J Funct Foods 49:424-436 (2018).
Mudenuti NVDR, de Camargo AC, Shahidi F, Madeira TB, Hirooka EY and Grossmann MVE, Soluble and insoluble-bound fractions of phenolics and alkaloids and their antioxidant activities in raw and traditional chocolate: a comparative study. J Funct Foods 50:164-171 (2018).
Mudenuti NV d R, de Camargo AC, de Alencar SM, Danielski R, Shahidi F, Madeira TB et al., Phenolics and alkaloids of raw cocoa nibs and husk: the role of soluble and insoluble-bound antioxidants. Food Biosci 42:101085 (2021).
Voora V, Bermúdez S and Larrea C, Global Market Report: Cocoa (2019).
Igawa TK, de Toledo PM and Anjos LJS, Climate change could reduce and spatially reconfigure cocoa cultivation in the Brazilian Amazon by 2050. PLoS One 17:1-14 (2022).
Heming NM, Schroth G, Talora DC and Faria D, Cabruca agroforestry systems reduce vulnerability of cacao plantations to climate change in southern Bahia. Agron Sustainable Dev 42:48 (2022).
Spada FP, Mandro GF, da Matta MD and Canniatti-Brazaca SG, Functional properties and sensory aroma of roasted jackfruit seed flours compared to cocoa and commercial chocolate powder. Food Biosci 37:100683 (2020).
Alves JLF, da Silva JCG, Mumbach GD, Di DM, da Silva Filho VF, de Sena RF et al., Insights into the bioenergy potential of jackfruit wastes considering their physicochemical properties, bioenergy indicators, combustion behaviors, and emission characteristics. Renew Energy 155:1328-1338 (2020).
Zhang Y, Li B, Xu F, He S, Zhang Y, Sun L et al., Jackfruit starch: composition, structure, functional properties, modifications and applications. Trends Food Sci Technol 107:268-283 (2021).
Arung ET, Shimizu K, Tanaka H and Kondo R, 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus. Fitoterapia 81:640-643 (2010).
Baliga MS, Shivashankara AR, Haniadka R, Dsouza J and Bhat HP, Phytochemistry, nutritional and pharmacological properties of Artocarpus heterophyllus Lam (jackfruit): a review. Food Res Int 44:1800-1811 (2011).
Fang SC, Hsu C-L and Yen G-C, Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem 56:4463-4468 (2008).
de Faria AF, de Rosso VV and Mercadante AZ, Carotenoid composition of jackfruit (Artocarpus heterophyllus), determined by HPLC-PDA-MS/MS. Plant Foods Hum Nutr 64:108-115 (2009).
Zhang L, Tu Z, Xie X, Wang H, Wang H, Wang Z et al., Jackfruit (Artocarpus heterophyllus Lam.) peel: a better source of antioxidants and a-glucosidase inhibitors than pulp, flake and seed, and phytochemical profile by HPLC-QTOF-MS/MS. Food Chem 234:303-313 (2017).
Trejo Rodríguez IS, Alcántara Quintana LE, Algara Suarez P, Ruiz Cabrera MA and Grajales Lagunes A, Physicochemical properties, antioxidant capacity, prebiotic activity and anticancer potential in human cells of jackfruit (Artocarpus heterophyllus) seed flour. Molecules 26:4854 (2021).
Zhang H and Tsao R, Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci 8:33-42 (2016).
Chai T, Xiao J, Mohana S, Teoh J and Ee K, Identification of antioxidant peptides derived from tropical jackfruit seed and investigation of the stability profiles. Food Chem 340:127876 (2021).
David J, Antioxidant properties of fibre rich dietetic chocolate cake developed by jackfruit (Artocarpus heterophyllus L.) seed flour. Int J Food Eng 2:132-135 (2016).
Martinelli E, Granato D, Azevedo L, Gonçalves JE, Lorenzo JM, Munekata PES et al., Current perspectives in cell-based approaches towards the definition of the antioxidant activity in food. Trends Food Sci Technol 116:232-243 (2021).
Chandrasekara A, Herath A, Abeynayake R, De Camargo AC and Shahidi F, Synergies of herbal teas on improved plasma antioxidant capacity and postprandial hypoglycemic response in healthy adults. J Food Bioact 13:82-92 (2021).
Ding X, Hu X, Chen Y, Xie J, Ying M, Wang Y et al., Differentiated Caco-2 cell models in food-intestine interaction study: current applications and future trends. Trends Food Sci Technol 107:455-465 (2021).
Maleki SJ, Crespo JF and Cabanillas B, Anti-inflammatory effects of flavonoids. Food Chem 299:125124 (2019).
Taniguchi K and Karin M, NF-B, inflammation, immunity and cancer: coming of age. Nat Rev Immunol 18:309-324 (2018).
Massarioli AP, de Oliveira Sartor AG, Juliano FF, do Amaral JEPG, dos Santos RC, de Lima LM et al., Simulated gastrointestinal digestion/Caco-2 cell model to predict bioaccessibility and intestinal permeability of p-coumaric acid and p-coumaroyl derivatives in peanut. Food Chem 400:134033 (2022).
Martelli Chaib Saliba AS, de Oliveira AG, Sartori A, Batista PS, do Amaral JEPG, da Silva NO et al., Simulated gastrointestinal digestion/Caco-2 cell transport: effects on biological activities and toxicity of a Brazilian propolis. Food Chem 403:134330 (2023).
Rasera GB, de Matos FM, de Souza Silva AP, de Alencar SM, Bridi R, de Camargo AC et al., Germination and its role in phenolic compound bioaccessibility for black mustard grains: a study using INFOGEST protocol. Food Chem 413:135648 (2023).
Brodkorb A, Egger L, Alminger M, Alvito P, Assunção R, Ballance S et al., INFOGEST static in vitro simulation of gastrointestinal food digestion. Nat Protoc 14:991-1014 (2019).
Baranowska M, Suliborska K, Todorovic V, Kusznierewicz B, Chrzanowski W, Sobajic S et al., Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract. Free Radic Biol Med 154:48-61 (2020).
Koss-Mikołajczyk I, Kusznierewicz B and Bartoszek A, The relationship between phytochemical composition and biological activities of differently pigmented varieties of berry fruits; comparison between embedded in food matrix and isolated anthocyanins. Foods 8:646 (2019).
Lazarini JG, Sardi JCO, Franchin M, Nani BD, Freires IA, Infante J et al., Bioprospection of Eugenia brasiliensis, a Brazilian native fruit, as a source of anti-inflammatory and antibiofilm compounds. Biomed Pharmacother 102:132-139 (2018).
Spada FP, Zerbeto LM, Ragazi GBC, Gutierrez ÉMR, Souza MC, Parker JK et al., Optimization of postharvest conditions to produce chocolate aroma from jackfruit seeds. J Agric Food Chem 65:1196-1208 (2017).
Melo PS, Massarioli AP, Denny C, Dos Santos LF, Franchin M, Pereira GE et al., Winery by-products: extraction optimization, phenolic composition and cytotoxic evaluation to act as a new source of scavenging of reactive oxygen species. Food Chem 181:160-169 (2015).
Kellett ME, Greenspan P and Pegg RB, Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line. Food Chem 244:359-363 (2018).
Wan H, Liu D, Yu X, Sun H and Li Y, A Caco-2 cell-based quantitative antioxidant activity assay for antioxidants. Food Chem 175:601-608 (2015).
Sardi JCO, Freires IA, Lazarini JG, Infante J, de Alencar SM and Rosalen PL, Unexplored endemic fruit species from Brazil: antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. Microb Pathog 105:280-287 (2017).
Megaw J, Thompson TP, Lafferty RA and Gilmore BF, Galleria mellonella as a novel in vivo model for assessment of the toxicity of 1-alkyl-3-methylimidazolium chloride ionic liquids. Chemosphere 139:197-201 (2015).
de Almeida Rochelle SL, JCO S, Freires IA, Galvão LCC, Lazarini JG, de Alencar SM et al., The anti-biofilm potential of commonly discarded agro-industrial residues against opportunistic pathogens. Ind Crops Prod 87:150-160 (2016).
Salvador I, Massarioli AP, Silva APS, Malaguetta H, Melo PS and Alencar SM, Can we conserve trans-resveratrol content and antioxidant activity during industrial production of chocolate? J Sci Food Agric 99:83-89 (2019).
Godos J, Marventano S, Mistretta A, Galvano F and Grosso G, Dietary sources of polyphenols in the Mediterranean healthy eating, aging and lifestyle (MEAL) study cohort. Int J Food Sci Nutr 68:750-756 (2017).
Samaniego I, Espín S, Quiroz J, Ortiz B, Carrillo W, García-Viguera C et al., Effect of the growing area on the methylxanthines and flavan-3-ols content in cocoa beans from Ecuador. J Food Compos Anal 88:103448 (2020).
González-Barrio R, Nuñez-Gomez V, Cienfuegos-Jovellanos E, García-Alonso FJ and Periago-Castón MJ, Improvement of the flavanol profile and the antioxidant capacity of chocolate using a phenolic rich cocoa powder. Foods 9:1-12 (2020).
Schaich KM, Tian X and Xie J, Hurdles and pitfalls in measuring antioxidant efficacy: a critical evaluation of ABTS, DPPH, and ORAC assays. J Funct Foods 14:111-125 (2015).
Gong J, Li J, Dong H, Chen G, Qin X, Hu M et al., Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88. BMC Complement Altern Med 19:1-12 (2019).
Rasera GB, de Camargo AC and de Castro RJS, Bioaccessibility of phenolic compounds using the standardized INFOGEST protocol: a narrative review. Compr Rev Food Sci Food Saf 22:260-286 (2023).
Yao W, Sun Q, Huang L, Meng G, Wang H, Jing X et al., Tetrahydroxystilbene glucoside inhibits TNF-α-induced migration of vascular smooth muscle cells via suppression of vimentin. Can J Physiol Pharmacol 94:155-160 (2016).
Ye JB, Ren G, Li WY, Zhong GY, Zhang M, Bin YJ et al., Characterization and identification of prenylated flavonoids from Artocarpus heterophyllus Lam. Roots by quadrupole time-of-flight and linear trap quadrupole Orbitrap mass spectrometry. Molecules 24:4591 (2019).
Kenny TP, Shu SA, Moritoki Y, Keen CL and Gershwin ME, Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro. J Med Food 12:1-7 (2009).
معلومات مُعتمدة: This research was funded by São Paulo Research Foundation (FAPESP), grant number 2018/19494.
فهرسة مساهمة: Keywords: Artocarpus heterophyllus; Caco-2 cells; Galleria mellonella; RAW 264.7 cells; bioavailability
المشرفين على المادة: 0 (Antioxidants)
0 (Tumor Necrosis Factor-alpha)
0 (NF-kappa B)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20230324 Date Completed: 20230608 Latest Revision: 20230608
رمز التحديث: 20240628
DOI: 10.1002/jsfa.12568
PMID: 36960787
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0010
DOI:10.1002/jsfa.12568