دورية أكاديمية
أعرض في EDS

Review and future perspectives on the integration characteristics for equine lentivirus in the host genome.

التفاصيل البيبلوغرافية
العنوان: Review and future perspectives on the integration characteristics for equine lentivirus in the host genome.
المؤلفون: Yu YY; Nanchong Key Laboratory of Disease Prevention, Control and Detection in Livestock and Poultry, Nanchong Vocational and Technical College, Nanchong 637131, China., Xu MS; Chongqing Three Gorges Vocational College, Wanzhou 404155, China., Liang H; Nanchong Key Laboratory of Disease Prevention, Control and Detection in Livestock and Poultry, Nanchong Vocational and Technical College, Nanchong 637131, China., Wang HY; Nanchong Key Laboratory of Disease Prevention, Control and Detection in Livestock and Poultry, Nanchong Vocational and Technical College, Nanchong 637131, China., Yu CQ; School of Advanced Agricultural Sciences, Yibin Vocational Technical College, Yibin 644003, China., Liu Q; Nanchong Key Laboratory of Disease Prevention, Control and Detection in Livestock and Poultry, Nanchong Vocational and Technical College, Nanchong 637131, China.
المصدر: Polish journal of veterinary sciences [Pol J Vet Sci] 2023 Mar; Vol. 26 (1), pp. 163-172.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Polish Academy of Sciences. Committee of Veterinary Sciences Country of Publication: Germany NLM ID: 101125473 Publication Model: Print Cited Medium: Internet ISSN: 2300-2557 (Electronic) Linking ISSN: 15051773 NLM ISO Abbreviation: Pol J Vet Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: <2016- > : [Olsztyn] : Polish Academy of Sciences. Committee of Veterinary Sciences ; University of Warmia and Mazury
Original Publication: Olsztyn, Poland : HARD Pub. Co., [1998-
مواضيع طبية MeSH: Equine Infectious Anemia*/prevention & control , Horse Diseases* , Infectious Anemia Virus, Equine*/genetics , Viral Vaccines*, Animals ; Humans ; Horses ; Lentiviruses, Equine ; Vaccines, Attenuated/genetics
مستخلص: Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.
(Copyright© by the Polish Academy of Sciences.)
فهرسة مساهمة: Keywords: equine infectious anemia virus; integration; lentivirus; long interspersed elements
المشرفين على المادة: 0 (Vaccines, Attenuated)
0 (Viral Vaccines)
تواريخ الأحداث: Date Created: 20230324 Date Completed: 20230328 Latest Revision: 20230328
رمز التحديث: 20231215
DOI: 10.24425/pjvs.2023.145019
PMID: 36961267
قاعدة البيانات: MEDLINE
الوصف
تدمد:2300-2557
DOI:10.24425/pjvs.2023.145019