دورية أكاديمية
أعرض في EDS

Principles of phosphoproteomics and applications in cancer research.

التفاصيل البيبلوغرافية
العنوان: Principles of phosphoproteomics and applications in cancer research.
المؤلفون: Higgins L; Cell Signaling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K., Gerdes H; Cell Signaling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K., Cutillas PR; Cell Signaling and Proteomics Group, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, U.K.; Alan Turing Institute, The British Library, London, U.K.; Digital Environment Research Institute, Queen Mary University of London, London, U.K.
المصدر: The Biochemical journal [Biochem J] 2023 Mar 31; Vol. 480 (6), pp. 403-420.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Published by Portland Press on behalf of the Biochemical Society
مواضيع طبية MeSH: Proteomics*/methods , Neoplasms*/drug therapy, Humans ; Phosphorylation ; Protein Processing, Post-Translational ; Phosphoproteins/metabolism ; Proteome/metabolism
مستخلص: Phosphorylation constitutes the most common and best-studied regulatory post-translational modification in biological systems and archetypal signalling pathways driven by protein and lipid kinases are disrupted in essentially all cancer types. Thus, the study of the phosphoproteome stands to provide unique biological information on signalling pathway activity and on kinase network circuitry that is not captured by genetic or transcriptomic technologies. Here, we discuss the methods and tools used in phosphoproteomics and highlight how this technique has been used, and can be used in the future, for cancer research. Challenges still exist in mass spectrometry phosphoproteomics and in the software required to provide biological information from these datasets. Nevertheless, improvements in mass spectrometers with enhanced scan rates, separation capabilities and sensitivity, in biochemical methods for sample preparation and in computational pipelines are enabling an increasingly deep analysis of the phosphoproteome, where previous bottlenecks in data acquisition, processing and interpretation are being relieved. These powerful hardware and algorithmic innovations are not only providing exciting new mechanistic insights into tumour biology, from where new drug targets may be derived, but are also leading to the discovery of phosphoproteins as mediators of drug sensitivity and resistance and as classifiers of disease subtypes. These studies are, therefore, uncovering phosphoproteins as a new generation of disruptive biomarkers to improve personalised anti-cancer therapies.
(© 2023 The Author(s).)
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معلومات مُعتمدة: 24375 United Kingdom CRUK_ Cancer Research UK
فهرسة مساهمة: Keywords: kinase biology; mass spectrometry; proteomics
المشرفين على المادة: 0 (Phosphoproteins)
0 (Proteome)
تواريخ الأحداث: Date Created: 20230324 Date Completed: 20230328 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10212522
DOI: 10.1042/BCJ20220220
PMID: 36961757
قاعدة البيانات: MEDLINE
الوصف
تدمد:1470-8728
DOI:10.1042/BCJ20220220