دورية أكاديمية
أعرض في EDS

Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.

التفاصيل البيبلوغرافية
العنوان: Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
المؤلفون: Toan ND; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Department of Paediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Darton TC; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom., Huong NHT; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam.; Department of Paediatrics, Vietnam National University School of Medicine, Ho Chi Minh City, Vietnam., Nhat LTH; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nguyen TNT; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Tuyen HT; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thinh LQ; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam., Mau NK; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam., Tam PTT; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Phuong CN; Hanh Phuc International Hospital, Binh Duong Province, Vietnam., Nhan LNT; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Minh NNQ; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam., Xuan NM; Department of Paediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Thuong TC; Department of Paediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.; Department of Health, Ho Chi Minh City, Vietnam., Hung NT; Clinical Departments, Children's Hospital 1, Ho Chi Minh City, Vietnam.; Department of Paediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.; Department of Paediatrics, Vietnam National University School of Medicine, Ho Chi Minh City, Vietnam., Boinett C; Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom., Reece S; Kymab, Babraham Research Campus, Cambridge, United Kingdom., Karkey A; Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Kathmandu, Nepal., Day JN; Hospital for Tropical Diseases, Wellcome Trust Africa and Asia Programmes, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Baker S; University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.
المصدر: PLOS global public health [PLOS Glob Public Health] 2022 Sep 02; Vol. 2 (9), pp. e0000875. Date of Electronic Publication: 2022 Sep 02 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 9918283779606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-3375 (Electronic) Linking ISSN: 27673375 NLM ISO Abbreviation: PLOS Glob Public Health Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, California : Public Library of Science, [2021]-
مستخلص: Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there are limited contemporaneous data linking the clinical features of neonatal sepsis with outcome in LMICs. Here, we aimed to identify factors associated with mortality from neonatal sepsis in Vietnam. We conducted a prospective, observational study to describe the clinical features, laboratory characteristics, and mortality rate of neonatal sepsis at a major children's hospital in Ho Chi Minh City. All in-patient neonates clinically diagnosed with probable or culture-confirmed sepsis meeting inclusion criteria from January 2017 to June 2018 were enrolled. We performed univariable analysis and logistic regression to identify factors independently associated with mortality. 524 neonates were recruited. Most cases were defined as late-onset neonatal sepsis and were hospital-acquired (91.4% and 73.3%, respectively). The median (IQR) duration of hospital stay was 23 (13-41) days, 344/524 (65.6%) had a positive blood culture (of which 393 non-contaminant organisms were isolated), and 69/524 (13.2%) patients died. Coagulase-negative staphylococci (232/405; 57.3%), Klebsiella spp. (28/405; 6.9%), and Escherichia coli (27/405; 6.7%) were the most isolated organisms. Sclerema (OR = 11.4), leukopenia <4,000/mm3 (OR = 7.8), thrombocytopenia <100,000/mm3 (OR = 3.7), base excess < -20 mEq/L (OR = 3.6), serum lactate >4 mmol/L (OR = 3.4), extremely low birth weight (OR = 3.2), and hyperglycaemia >180 mg/dL (OR = 2.6) were all significantly (p<0.05) associated with mortality. The identified risk factors can be adopted as prognostic factors for the diagnosis and treatment of neonatal sepsis and enable early risk stratification and interventions appropriate to reduce neonatal sepsis in LMIC settings.
Competing Interests: SR is affiliated with Kymab Ltd. There are no patents, products in development or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The authors have declared that no other competing interests exist.
(Copyright: © 2022 Toan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20230324 Latest Revision: 20230327
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10021837
DOI: 10.1371/journal.pgph.0000875
PMID: 36962870
قاعدة البيانات: MEDLINE
الوصف
تدمد:2767-3375
DOI:10.1371/journal.pgph.0000875