دورية أكاديمية
Symptomatic subgemmal neurogenous plaque in patients with COVID-19: Is there an association?
| العنوان: | Symptomatic subgemmal neurogenous plaque in patients with COVID-19: Is there an association? |
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| المؤلفون: | Soares CD; Pathology Department, Getulio Sales Diagnósticos, Natal, Brazil.; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., de Souza LL; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Pathology, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Laffitte CM; Department of Periodontology, Federal University of Rio Grande do Norte, Natal, Brazil., Pontes HAR; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Pathology, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Almeida OP; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Mosqueda-Taylor A; Health Care Department, Universidad Autónoma Metropolitana, Mexico City, Mexico., Hernandez-Guerrero JC; Department of Immunology, Universidad Nacional Autónoma de México, Mexico City, Mexico., Vargas PA; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Lopes MA; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Dos Santos-Silva AR; Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., da Costa Gurgel A; Pathology Department, Getulio Sales Diagnósticos, Natal, Brazil., de Andrade Pacheco MM; Pathology Department, Getulio Sales Diagnósticos, Natal, Brazil., de Oliveira Sales A; Pathology Department, Getulio Sales Diagnósticos, Natal, Brazil., de Oliveira Ramos CC; Pathology Department, Getulio Sales Diagnósticos, Natal, Brazil. |
| المصدر: | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2023 Jul; Vol. 52 (6), pp. 514-520. Date of Electronic Publication: 2023 Mar 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Wiley-Blackwell Original Publication: Copenhagen : Munksgaard, c1989- |
| مواضيع طبية MeSH: | Taste Buds*/metabolism , Taste Buds*/pathology , COVID-19*/complications , COVID-19*/metabolism , COVID-19*/pathology , Dental Plaque*, Humans ; Tongue/pathology ; Keratins/metabolism |
| مستخلص: | Background: Subgemmal neurogenous plaques (SNP) are composed of neural structures found in the posterolateral portion of the tongue, rarely biopsied as most of them are asymptomatic or eventually only clinically managed. We aimed to investigate a case series of possible correlation of symptomatic subgemmal neurogenous plaque (SNP) with coronavirus disease 2019 (COVID-19). Methods: Eleven formalin-fixed paraffin-embedded cases from patients with previous confirmed COVID-19 (by RT-PCR) were retrieved from two pathology files. Histological sections were morphologically studied, and then submitted to immunohistochemical reactions against S-100 and neurofilament proteins, neuron-specific enolase, Glial fibrillary acidic protein (GFAP), synaptophysin, CD56, Ki67, cytokeratins (7, 8-18, 19, 20), nucleocapsid and spike proteins (SARS-CoV-1; and -2) and epithelial membrane antigen (EMA) antibodies. Clinical data were retrieved from the patients' medical files, including the symptoms and the complete history of the progression of the disease. Results: The patients who had COVID-19 included in this study experienced painful lesions in the tongue that corresponded to prominent or altered SNP. Microscopically, neural structures were positive for S-100, GFAP and neurofilament protein. And the cellular proliferative index (by Ki-67) was very low. Conclusion: Thus, based on the current results, we hypothesize that symptomatic SNP may be a late manifestation of COVID-19 infection. (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; neural; subgemmal neurogenous plaques; tongue |
| المشرفين على المادة: | 68238-35-7 (Keratins) |
| تواريخ الأحداث: | Date Created: 20230325 Date Completed: 20230713 Latest Revision: 20230718 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/jop.13430 |
| PMID: | 36964982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-0714 |
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| DOI: | 10.1111/jop.13430 |