دورية أكاديمية
أعرض في EDS

Clinical and anatomic correlates of objectively measured zonular dehiscence in 427 postmortem pseudophakic eyes.

التفاصيل البيبلوغرافية
العنوان: Clinical and anatomic correlates of objectively measured zonular dehiscence in 427 postmortem pseudophakic eyes.
المؤلفون: Nassrallah EI; From the Research Institute of the McGill University Health Centre, Montreal, QC. Electronic address: emmanuel.nassrallah@mail.mcgill.ca., Nassrallah GB; Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, ON., Mastromonaco C; From the Research Institute of the McGill University Health Centre, Montreal, QC., Denis R; From the Research Institute of the McGill University Health Centre, Montreal, QC., Dias AB; From the Research Institute of the McGill University Health Centre, Montreal, QC., Saheb N; From the Research Institute of the McGill University Health Centre, Montreal, QC., Burnier MN; From the Research Institute of the McGill University Health Centre, Montreal, QC.
المصدر: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie [Can J Ophthalmol] 2024 Jun; Vol. 59 (3), pp. e193-e199. Date of Electronic Publication: 2023 Mar 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0045312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1715-3360 (Electronic) Linking ISSN: 00084182 NLM ISO Abbreviation: Can J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: June 2011- : Oxford, England : Elsevier
Original Publication: Montreal, Canadian Ophthalmological Society.
مواضيع طبية MeSH: Pseudophakia*, Humans ; Male ; Female ; Aged ; Cross-Sectional Studies ; Aged, 80 and over ; Middle Aged ; Ciliary Body/pathology ; Autopsy ; Adult ; Lens Capsule, Crystalline/pathology
مستخلص: Objective: This study aims to objectively measure the degree of zonular dehiscence in postmortem eyes and to assess for clinical and anatomic correlates.
Design: Cross-sectional study.
Materials: Four hundred and twenty-seven postmortem pseudophakic human eyes.
Methods: Eyes were obtained from the Lions Gift of Sight Eye Bank. Microscope photographs were taken of the eyes in Miyake-Apple view, and region-of-interest analysis was performed using ImageJ to measure the area, circumference, and diameter of the capsular bag, the ciliary ring, and the capsulorhexis. Clinical and anatomic parameters were assessed using simple linear regression analysis and one-way analysis of variance with post hoc Bonferroni testing. Zonular dehiscence was measured via 2 surrogates: capsule area over ciliary ring area ratio (CCR) and capsule-ciliary ring decentration (CCD). Low CCR and high CCD indicate more zonular dehiscence.
Results: CCR was significantly inversely correlated with smaller capsulorhexi (p = 0.012), lower intraocular lens power (p < 0.00001), younger age at death (p = 0.00002), and a longer cataract-to-death time (p = 0.00786). CCR also was significantly lower in glaucomatous cases (p = 0.0291). CCD was significantly correlated with longer cataract-to-death time (p = 0.000864), larger ciliary ring area (p = 0.001), more posterior capsule opacification (p = 0.0234), and higher Soemmering's ring opacity (p = 0.0003). There was also significantly more decentration in male eyes than in female eyes (p = 0.00852).
Conclusions: CCR and CCD are novel measures of zonular dehiscence in postmortem eyes, with many interesting correlates. An enlarged ciliary ring area is possibly associated with zonular dehiscence in pseudophakic eyes and may be a quantifiable surrogate in vivo.
(Copyright © 2023 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.)
تواريخ الأحداث: Date Created: 20230326 Date Completed: 20240515 Latest Revision: 20240515
رمز التحديث: 20240516
DOI: 10.1016/j.jcjo.2023.03.001
PMID: 36966817
قاعدة البيانات: MEDLINE
الوصف
تدمد:1715-3360
DOI:10.1016/j.jcjo.2023.03.001