دورية أكاديمية
Evaluation of Static and Dynamic Pupillary Functions in Early-Stage Primary Open Angle Glaucoma.
العنوان: | Evaluation of Static and Dynamic Pupillary Functions in Early-Stage Primary Open Angle Glaucoma. |
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المؤلفون: | Bayraktar S; The University of Health Sciences, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey., Hondur G, Şekeroğlu MA, Şen E |
المصدر: | Journal of glaucoma [J Glaucoma] 2023 Jul 01; Vol. 32 (7), pp. e90-e94. Date of Electronic Publication: 2023 Mar 22. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc. Original Publication: New York, N.Y. : Raven Press, c1992- |
مواضيع طبية MeSH: | Glaucoma, Open-Angle*/diagnosis, Humans ; Cross-Sectional Studies ; Prospective Studies ; Intraocular Pressure ; Pupil/physiology ; Reflex, Pupillary/physiology |
مستخلص: | Prcis: The dynamic parameters of the pupil, evaluated with an automated pupillometry device, differ in newly diagnosed early-stage primary open angle glaucoma (POAG) patients compared with healthy individuals, and this may guide us in early diagnosis and follow-up of glaucoma. Introduction and Aim: To quantitatively determine static and dynamic pupillary functions in treatment-naive, newly diagnosed early-stage POAG patients and compare them with healthy controls. Methods: Forty eye of forty subjects with early POAG were compared with 71 eye of 71 age- matched and sex-matched healthy controls in terms of static and dynamic pupillary functions in this prospective and cross-sectional study. Static and dynamic pupillary functions were obtained with an automated pupillometry device. Static pupillometry parameters are pupil diameter (mm) in high photopic (100 cd/m 2 ), low photopic (10 cd/m 2 ), mesopic (1 cd/m 2 ), and scotopic (0.1 cd/m 2 ) light conditions. Dynamic pupillometry parameters are resting diameter (mm), amplitude (mm), latency (ms), duration (ms), and velocity (mm/s) of pupil contraction and dilation. Measured data were evaluated and compared with t test for independent groups. Results: Duration of pupil contraction was lower, ( P =0.04) latency of pupil dilation time was longer, ( P =0.03) duration of pupil dilation was shorter ( P =0.04) and velocity of pupil dilation was lower ( P =0.02) in the POAG group. There was no significant difference between the 2 groups in terms of static pupillometry characteristics and the resting pupil diameter ( P >0.05 for all values). Conclusion: These results suggest that dynamic pupillary light responses may be affected in early-stage POAG compared with the normal population. Longitudinal studies with larger series are needed to better understand the quantitative changes in dynamic pupillometry functions in early-stage POAG. Competing Interests: Disclosure: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
References: | Stamper RL, Lieberman MF, Drake MV Stamper RL, Lieberman MF, Drake MV. Primary open angle glaucoma. Becker-Shaffer’s Diagnosis and Therapy of the Glaucomas. Mosby; 2009:239–265. Kastner A, K AJ. Advanced glaucoma at diagnosis: current perspectives. Eye (London). 2020;34:116–28. Martucci A, Cesareo M, Napoli D, et al. Evaluation of pupillary response to light in patients with glaucoma: a study using computerized pupillometry. Int Ophthalmol. 2014;34:1241–1247. Kelbsch C, Maeda F, Strasser T, et al. Pupillary responses driven by ipRGCs and classical photoreceptors are impaired in glaucoma. Graefes Arch Clin Exp Ophthalmol. 2016;254:1361–1370. Adhikari P, Zele AJ, Thomas R, et al. Quadrant field pupillometry detects melanopsin dysfunction in glaucoma suspects and early glaucoma. Sci Rep. 2016;6:33373. Tekin K, Kiziltoprak H, Sekeroglu MA, et al. Static and dynamic pupil characteristics in pseudoexfoliation syndrome and glaucoma. Clin Exp Optom. 2020;103:332–338. Chang DS, Arora KS, Boland MV, et al. Development and validation of an associative model for the detection of glaucoma using pupillography. Am J Ophthalmol. 2013;156:1285–1296 e2. Suo L, Zhang D, Qin X, et al. Evaluating state-of-the-art computerized pupillary assessments for glaucoma detection: a systematic review and meta-analysis. Front Neurol. 2020;11:777. Najjar RP, Sharma S, Atalay E, et al. Pupillary responses to full-field chromatic stimuli are reduced in patients with early-stage primary open-angle glaucoma. Ophthalmology. 2018;125:1362–1371. Rukmini AV, Milea D, Gooley JJ. Chromatic pupillometry methods for assessing photoreceptor health in retinal and optic nerve diseases. Front Neurol. 2019;10:76. Feigl B, Mattes D, Thomas R, et al. Intrinsically photosensitive (melanopsin) retinal ganglion cell function in glaucoma. Invest Ophthalmol Vis Sci. 2011;52:4362–4367. Bremner FD. Pupillometric evaluation of the dynamics of the pupillary response to a brief light stimulus in healthy subjects. Invest Ophthalmol Vis Sci. 2012;53:7343–7347. Park HL, Jung SH, Park SH, et al. Detecting autonomic dysfunction in patients with glaucoma using dynamic pupillometry. Medicine (Baltimore). 2019;98:e14658. Kurysheva NI, Ryabova TY, Shlapak VN. Heart rate variability: the comparison between high tension and normal tension glaucoma. EPMA J. 2018;9:35–45. Park HY, Park SH, Park CK. Central visual field progression in normal-tension glaucoma patients with autonomic dysfunction. Invest Ophthalmol Vis Sci. 2014;55:2557–2563. Tekin K, Sekeroglu MA, Kiziltoprak H, et al. Static and dynamic pupillometry data of healthy individuals. Clin Exp Optom. 2018;101:659–665. Lowenstein O, Loewenfeld IE. Electronic pupillography;a new instrument and some clinical applications. AMA Arch Ophthalmol. 1958;59:352–363. Schroder S, Chashchina E, Janunts E, et al. Reproducibility and normal values of static pupil diameters. Eur J Ophthalmol. 2018;28:150–156. Herbst K, Sander B, Lund-Andersen H, et al. Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens. BMC Ophthalmol. 2012;12:4. Age-Related Eye Disease Study Research Group. The age-related eye disease study (AREDS) system for classifying cataracts from photographs: AREDS report no. 4. Am J Ophthalmol. 2001;131:167–175. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 2: Classification and terminology. Supported by the EGS Foundation: Br J Ophthalmol. 2017;101:84–85. Hodapp E, Parrish RK, Anderson DR. Clinical Decisions in Glaucoma. Mosby; 1993:52–61. Erdem U, Gundogan FC, Dinc UA, et al. Acute effect of cigarette smoking on pupil size and ocular aberrations: a pre- and postsmoking study. J Ophthalmol. 2015;2015:625470. Mathot S. Pupillometry: psychology, physiology, and function. J Cogn. 2018;1:16. Kankipati L, G C, Gamlin PD. The post-illumination pupil response is reduced in glaucoma patients. Invest Ophthalmol Vis Sci. 2011;52:2287–2292. Winn B, Whitaker D, Elliott DB, et al. Factors affecting light-adapted pupil size in normal human subjects. Invest Ophthalmol Vis Sci. 1994;35:1132–1137. Hammond CJ, Snieder H, Spector TD, et al. Factors affecting pupil size after dilatation: the Twin Eye Study. Br J Ophthalmol. 2000;84:1173–1176. Park JW, Kang BH, Kwon JW, et al. Analysis of various factors affecting pupil size in patients with glaucoma. BMC Ophthalmol. 2017;17:168. Kankipati L, G C, Gamlin PD. Post-illumination pupil response in subjects without ocular disease. Invest Ophthalmol Vis Sci. 2010;51:2764–2769. Adhikari P, Pearson CA, Anderson AM, et al. Effect of age and refractive error on the melanopsin mediated post-illumination pupil response (PIPR). Sci Rep. 2015;5:17610. Provencio I, Rodriguez IR, Jiang G, et al. A novel human opsin in the inner retina. J Neurosci. 2000;20:600–605. Pickard GE, Sollars PJ. Intrinsically photosensitive retinal ganglion cells. Rev Physiol Biochem Pharmacol. 2012;162:59–90. Gamlin PD, McDougal DH, Pokorny J, et al. Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Res. 2007;47:946–954. Feigl B, Zele AJ. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells in retinal disease. Optom Vis Sci. 2014;91:894–903. de Zavalia N, Plano SA, Fernandez DC, et al. Effect of experimental glaucoma on the non-image forming visual system. J Neurochem. 2011;117:904–914. Wang HZ, Lu QJ, Wang NL, et al. Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model. Chin Med J (Engl). 2008;121:1015–1019. Grozdanic SD, Kwon YH, Sakaguchi DS, et al. Functional evaluation of retina and optic nerve in the rat model of chronic ocular hypertension. Exp Eye Res. 2004;79:75–83. Li RS, Chen BY, Tay DK, et al. Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model. Invest Ophthalmol Vis Sci. 2006;47:2951–2958. |
تواريخ الأحداث: | Date Created: 20230327 Date Completed: 20230630 Latest Revision: 20230729 |
رمز التحديث: | 20240628 |
DOI: | 10.1097/IJG.0000000000002212 |
PMID: | 36971579 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-481X |
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DOI: | 10.1097/IJG.0000000000002212 |