دورية أكاديمية
Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections.
العنوان: | Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections. |
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المؤلفون: | Le T; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA., Nang SC; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Zhao J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Yu HH; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Li J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Gill JJ; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Animal Science, Texas A&M University, College Station, Texas, USA., Liu M; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA., Aslam S; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.; Center for Innovative Phage Applications and Therapeutics, University of California San Diego, La Jolla, California, USA. |
المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Apr 18; Vol. 67 (4), pp. e0003723. Date of Electronic Publication: 2023 Mar 28. |
نوع المنشور: | Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
مواضيع طبية MeSH: | beta-Lactamases*/therapeutic use , Urinary Tract Infections*/drug therapy, Humans ; Anti-Bacterial Agents/therapeutic use ; Klebsiella pneumoniae ; Retrospective Studies |
مستخلص: | Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up. |
References: | BMC Nephrol. 2019 Dec 27;20(1):479. (PMID: 31881863) Antibiotics (Basel). 2020 May 26;9(6):. (PMID: 32466463) Clin Microbiol Rev. 2019 Jan 16;32(2):. (PMID: 30651225) Antimicrob Agents Chemother. 2019 Dec 20;64(1):. (PMID: 31611357) Transplant Proc. 2016 Jun;48(5):1580-9. (PMID: 27496451) Viruses. 2021 Oct 12;13(10):. (PMID: 34696479) Viral Immunol. 2014 Aug;27(6):295-304. (PMID: 24893003) J Nephrol. 2019 Aug;32(4):661-668. (PMID: 30701457) Nat Med. 2021 Aug;27(8):1357-1361. (PMID: 34239133) Emerg Microbes Infect. 2020 Dec;9(1):771-774. (PMID: 32212918) Clin Microbiol Infect. 2021 Mar;27(3):398-405. (PMID: 32919076) Transpl Infect Dis. 2021 Feb;23(1):e13391. (PMID: 32599666) Lancet Infect Dis. 2022 Aug;22(8):e208-e220. (PMID: 35248167) Open Forum Infect Dis. 2020 Aug 27;7(9):ofaa389. (PMID: 33005701) J Clin Microbiol. 2012 Dec;50(12):4002-7. (PMID: 23035197) Science. 2015 Dec 4;350(6265):1163-4. (PMID: 26785457) Nat Commun. 2019 Dec 4;10(1):5521. (PMID: 31797927) Viruses. 2021 Jun 21;13(6):. (PMID: 34205687) J Glob Antimicrob Resist. 2018 Mar;12:119-123. (PMID: 28859935) Annu Rev Med. 2022 Jan 27;73:197-211. (PMID: 34428079) Am J Transplant. 2021 Jan;21(1):198-207. (PMID: 32506639) |
معلومات مُعتمدة: | R21 AI156766 United States AI NIAID NIH HHS; U19 AI157981 United States AI NIAID NIH HHS; UL1 TR001442 United States TR NCATS NIH HHS |
فهرسة مساهمة: | Keywords: ESBL; bacteriophage; kidney transplant; phage; rUTI |
المشرفين على المادة: | EC 3.5.2.6 (beta-Lactamases) 0 (Anti-Bacterial Agents) |
تواريخ الأحداث: | Date Created: 20230328 Date Completed: 20230420 Latest Revision: 20230929 |
رمز التحديث: | 20230929 |
مُعرف محوري في PubMed: | PMC10112157 |
DOI: | 10.1128/aac.00037-23 |
PMID: | 36975787 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-6596 |
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DOI: | 10.1128/aac.00037-23 |