دورية أكاديمية
Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections.
| العنوان: | Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections. |
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| المؤلفون: | Le T; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA., Nang SC; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Zhao J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Yu HH; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Li J; Biomedicine Discovery Institute, Infection Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia., Gill JJ; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Animal Science, Texas A&M University, College Station, Texas, USA., Liu M; Center for Phage Technology, Texas A&M AgriLife Research, Texas A&M University, College Station, Texas, USA.; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA., Aslam S; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.; Center for Innovative Phage Applications and Therapeutics, University of California San Diego, La Jolla, California, USA. |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Apr 18; Vol. 67 (4), pp. e0003723. Date of Electronic Publication: 2023 Mar 28. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | beta-Lactamases*/therapeutic use , Urinary Tract Infections*/drug therapy, Humans ; Anti-Bacterial Agents/therapeutic use ; Klebsiella pneumoniae ; Retrospective Studies |
| مستخلص: | Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up. |
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| معلومات مُعتمدة: | R21 AI156766 United States AI NIAID NIH HHS; U19 AI157981 United States AI NIAID NIH HHS; UL1 TR001442 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: ESBL; bacteriophage; kidney transplant; phage; rUTI |
| المشرفين على المادة: | EC 3.5.2.6 (beta-Lactamases) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230328 Date Completed: 20230420 Latest Revision: 20230929 |
| رمز التحديث: | 20230929 |
| مُعرف محوري في PubMed: | PMC10112157 |
| DOI: | 10.1128/aac.00037-23 |
| PMID: | 36975787 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-6596 |
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| DOI: | 10.1128/aac.00037-23 |