دورية أكاديمية
M 4 muscarinic receptors mediate acetylcholine-induced suppressant effects on the cough reflex in the caudal nucleus tractus solitarii of the rabbit.
| العنوان: | M |
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| المؤلفون: | Cinelli E; Section of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Iovino L; Section of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Bongianni F; Section of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Pantaleo T; Section of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Lavorini F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Mannini C; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Mutolo D; Section of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. |
| المصدر: | American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2023 May 01; Vol. 324 (5), pp. L712-L721. Date of Electronic Publication: 2023 Mar 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1989- |
| مواضيع طبية MeSH: | Solitary Nucleus*/physiology , Acetylcholine*/pharmacology, Animals ; Rabbits ; Cough/chemically induced ; Cough/drug therapy ; Muscarine/pharmacology ; Receptors, Muscarinic ; Reflex ; Muscarinic Antagonists/adverse effects |
| مستخلص: | It has been shown that muscarinic acetylcholine receptors (mAChRs) located within the caudal nucleus tractus solitarii (cNTS) mediate a cholinergic inhibitory control mechanism of the cough reflex. Thus, identification of the involved mAChR subtypes could be of considerable interest for novel therapeutic strategies. In pentobarbital sodium-anesthetized, spontaneously breathing rabbits we investigated the contribution of different mAChR subtypes in the modulation of mechanically and chemically induced cough reflex. Bilateral microinjections of 1 mM muscarine into the cNTS increased respiratory frequency and decreased expiratory activity even to complete suppression. Interestingly, muscarine induced strong cough-suppressant effects up to the complete abolition of the reflex. Microinjections of specific mAChR subtype antagonists (M |
| التعليقات: | Comment in: Am J Physiol Lung Cell Mol Physiol. 2023 Jul 1;325(1):L91. (PMID: 37405947) |
| فهرسة مساهمة: | Keywords: M4 muscarinic receptors; cough reflex; muscarine; nicotine; nucleus tractus solitarii |
| المشرفين على المادة: | N9YNS0M02X (Acetylcholine) 7T101UWZ5W (Muscarine) 0 (Receptors, Muscarinic) 0 (Muscarinic Antagonists) |
| تواريخ الأحداث: | Date Created: 20230328 Date Completed: 20230505 Latest Revision: 20230720 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1152/ajplung.00325.2022 |
| PMID: | 36976922 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1504 |
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| DOI: | 10.1152/ajplung.00325.2022 |